难治疗的

Advance basic research has confirmed that the alkaloids extracted from thunberg fritillary bulb which is widely used in clinical medicine in vitro and in animal experiments have reversed MDR of leukemia. It will increase resistance of acute leukemia cells anticancer drug concentration and lower resistance the expression of Pgp. Pre-Clinical Experimental Research also shows that the conventional chemotherapy combined with the powder of thunberg fritillary bulb for the treatment of acute leukemia. Clinical complete response rate was higher, especially for patients with refractory or relapsed leukemia patients better clinical remission rate. In addition, Caladium particles Slices with chemotherapy in the treatment of RAL Clinical studies also show the Chinese refractory leukemia improve clinical efficacy safe and reliable.

先期基础研究已证实：临床常用的化痰散结中药浙贝母提取的生物碱体外及动物实验均有逆转白血病多药耐药的生物活性，能增加耐药的急性白血病细胞内抗癌药物浓度，降低耐药蛋白Pgp的表达；临床预实验研究也表明，常规化疗方案配合浙贝母粉用于急性白血病临床治疗，其临床完全缓解率明显高于对照组，尤其对难治及复发白血病患者临床缓解率更佳；此外，单药浙贝母颗粒配合化疗治疗RAL的临床研究亦显示中药在提高难治性白血病临床疗效方面安全可靠。

ABSTRACT Rheumatoid arthritis is a kind of autoimmunity disease which therapy hardly, It's etiological unknown up to now, The Traditional Chinese medicine has potential superiority on the disease, while modern medicine has so much ill effect. Blood benefited and circulating method has so thick theory background and comprehensive clinical verification, but deficit explanation of modern digit.

类风湿性关节炎是一种难治性自身免疫性疾病，至今病因未明，西医对其治疗存在许多问题，中医药治疗此病具有潜在的优势，养血活血法治疗此病有着浓厚的理论基础及广泛的临床验证，但缺乏现代数字化的解释，这是中医药真正走向世界所急待解决的问题。

Objective To discuss the surgical treatment of intractable post-traumatic epilepsy and its effect.

目的 探讨难治性外伤件癫痫的外科治疗方法及治疗效果。

Curative effect were in therapeutic group than in control group. rapy of intractably therapeutic cervicitis not only need comprehensive treatment, but also need detect Mycoplasma in order to cure it aiming at cause of the disease.

研究组疗效明显优于对照组；对于难治性宫颈炎除要进行综合治疗外，尚要检测病原体，针对病因进行治疗，以达到治愈的目的。

Therapy of intractably therapeutic cervicitis not only need comprehensive treatment, but also need detect Mycoplasma in order to cure it aiming at cause of the disease.

研究组疗效明显优于对照组；对于难治性宫颈炎除要进行综合治疗外，尚要检测病原体，针对病因进行治疗，以达到治愈的目的。

Rats with CHF were divided randomly into two groups, one group was injected dexamethasone(1mg /kg) intramuscularly at the first and forth day respectively,the other group was injected equi-volume saline likewise, and observing the changes of symptoms of rats with CHF; measuring rats hemodynamics index including blood pressure, heart rate and left ventricular end-diastolic pressure 4 days later. Part 2: To measure every group rats myocardialα1、β1、β2、β3-AR density by immunohistochemical method ,and to understand the AR density changes .Taking the first part rats'myocardium tissues for testing myocardialα1、β1、β2、β3-AR density and 5 normal rats for normo-contrast group and taking gray scale of slice as AR density. Part 3: The study enrolled 35 patients with DCHF. Patients were included if they had orthopnea and refractory edema due to acute DCHF that was severe and had taken more 1 week hospitalization and intravenous therapy in addition to diuretics.

观察心衰大鼠的症状，4天后对两组大鼠进行血流动力学检测，检测指标包括血压、心率和左室舒张末压；第二部分：取第一部分实验动物大鼠的心肌组织，并取5只正常大鼠的心肌组织作为正常对照，用免疫组化法检测大鼠心衰前后及糖皮质激素治疗前后大鼠心肌组织肾上腺素能受体α1、β1、β2、β3受体的变化，取镜下切片的灰度值反应受体的密度；第三部分：研究对象为临床难治性心衰病人35例，病人的选择标准包括由于急性失代偿的心力衰竭出现的端坐呼吸，难治性水肿，患者病情严重，住院超过1周，包括利尿剂之外药物的静脉治疗。

With the progress of molecular biology and the recognition of molecular pathology, the studies of s...

随着分子生物学技术的发展和对疾病分子病理学认识的深入，使得某些难治性疾病的研究进入了基因治疗的时代。

TREATMENT: Except for anti-coagulation therapy, aminophyllini was an inexpensive medicine to treat PTE, it could largly lower Hb and Hct by reducing the secretion of EPO. Its defect was rechallenge of PTE with the drug stopped, and repeated administration was still effective. The side effect was exciting symptoms. Enalapril was a storng hypotensor which could also greatly lower Hb and Hct with the decline in PRA/AT-Ⅱ, and then decreasing serum EPO. In this therapy blood pressure shonld be monitored to prevent from postural hypotention. At last, it showed that diltiazemi had no obvious effect on PTE.

四、治疗研究：分别以氨茶碱、恬尔心、Enalapril来治疗PTE病人，发现氨茶碱能明显降低PTE病人的Hb及Hct，且该作用与EPO降低有关，其缺点是停用后可引起复发，但继续服用仍有效，该药的副作用主要为头痛、失眠等兴奋症状；Enalapril不但能显著降低Hb及Hct，还可治疗难治性高血压，适用于伴有高血压的PTE病人；恬尔心对PTE的治疗作用不大。

To study the significance of using mutiple targes in intractale psychosis, 120 patients were treated by stereotactic technique combined with CT, MRI, microelectrode, and electric impedance methods with bilateral multiple nuclei lesioning by radio frequency thermocoagulation.

在立体定向基础上，应用CT、MRI、微电极和电阻值联合的多元化定位方法，对 12 0例难治性精神病患者，采用不同核团组合的双侧多靶点技术进行射频热凝治疗，应用CGI、BPRS、PANSS等精神病量表进行术前、术后的对照分析，以探讨不同靶点组合对难治性精神病的治疗意义。

Such signature themes as male bonding and David-and-Goliath face-offs still drive the action, but the functional script has dismantled much of the original storys dramatic intricacies and character complexities, then reassembled it into a easy-to-follow three-act structure.

吴宇森的招牌风格，诸如兄弟情意和以弱胜强的对抗仍在影片中占有主导地位，但为实用而编写的剧本对原故事大部分戏剧性青山丽子，杭州一夜情网站，治疗慢性荨麻疹偏方，明星合成图网的错综复杂的情节和人物角色多变难控的关系有所改动，从新改编成易于遵从的三幕剧结构。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。