难治疗的

Science,1993,262:1274[8] Baffy G,Miyashita T,Williamson JR,et al.Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced BCL-2 oncoprotein production.

本实验观察到11例未缓解、难治复发急性白血病均呈BCL-2mRNA表达阳性，而9例完全缓解患者中仅2例为BCL-2mRNA表达阳性(P.01)，结果支持BCL-2介导使细胞逃脱生理性凋亡、抵抗机体自然防御与临床治疗的机制，并与Campos等的报道类似[3]。

Methods 24 cases of IE treated microsurgically in last 5 years were analyzed retrospectively, and 4 cases of IE were analyzed prospectively.13 of them underwent combined operations.

回顾性分析5年来经显微手术治疗的24例难治性癫痫病例，前瞻性研究4例手术治疗的难治性癫痫病例，共计28例。

Methods A total of 430 eyes in 251 cases of diabetic focal macular edema, diffuse edema and cystoid edema were treated with krypton yellow laser photocoagulation.

目前激光光凝术已成为治疗糖尿病性黄斑水肿的常用方法，但激光参数的选择是临床治疗十分重要而又难统一的问题。

Now, researches on CHF pathogenesis and treatment have evolved deeply. CHF medication can achieve anticipated curative effect at the early stage, however, which is difficult to have the intended effect for decompensate CHF. Patients with DCHF often emerge oliguria, internal environment disorders and renal failure and died at the end stages.

目前，人类对于心衰的发病机制及治疗的研究已相当深入，在心衰失代偿早期通过药物治疗尚能达到较为满意的疗效，但是对于难治性心衰的患者药物治疗难以奏效，患者往往因顽固性心衰而出现少尿、内环境紊乱、肾功能衰竭而死亡。

Methods On the basis of the traditional treatment,Methylprednisolone was added in the treatment of refractory Kawasaki disease.

在传统治疗的基础上加用甲基强的松龙冲击治疗难治性川崎病。

The median time to achieve a neutrophile count of 0.5×109/L was 10 days after the last dose of chemotherapy in regimen A,and the time was 16 days in regimen B.The average SLEDAI decreased from 9.2 to 4.4,and the proteinuria decreased from to (0~+) in 3 weeks after the treatment.Two cases with complication of hemolytic anemia and 1 with thrombocytopenia before the treatment recovered to normal or nearly normal hemogram respectively.Among these 5 cases,1 patient had a short time improvement during the therapy,but died 50 days later because of refractory thrombosis of renal vein; 4 other patients achieved complete or partial remission within 5~16 months follow-up.

结果方案1从CTX结束算起，中性粒细胞恢复到0.5×109/L平均需10d，方案2从Ara-C结束起，中性粒细胞恢复到0.5×109/L需16d；治疗3周时 SLEDAI平均从9.2降至4.4，尿蛋白从降至(0~+)，合并有重度难治性贫血或血小板减少者，治疗后血红蛋白或血小板分别恢复正常或接近正常；方案2治疗的1例由于肾血管血栓形成未能控制，病情短暂好转后再度恶化，1个月后死于DIC和肾功能衰竭；另4例随访5~16个月，病情基本控制。

Refractory schizophrenia. Methods 60 TRS patients on antipsychotics were added to MECT for 12 weeks.

对60例难治性精神分裂症患者在原服用抗精神病药物治疗的基础上联合无抽搐电休克治疗，观察12 w。

The paper's lead author, Duke University molecular genetics and microbiology post-doctoral Lee Chung-chang said: Nosema infection treatment is difficult, because we know little of its 50%% of AIDS patients suffered Nosema fungal infection Caused chronic diarrhea.

该论文的主要作者、杜克大学分子遗传学和微生物学博士后李颂昌说：微孢子虫感染很难治疗，因为我们对其知之甚少，50%%的艾滋病患者遭遇微孢子真菌感染，引发慢性腹泻。

I would be hard pressed to recall any couple who presented for marital psychotherapy with a healthy sex life.

我很难回忆起有哪一对来寻求婚姻心理治疗的夫妇拥有一个健康的性生活。

Shanghai Sunway Biotech Co. Ltd. announced today that the Chinese State Food and Drug Administration has approved H101, an oncolytic adenovirus, to be used in combination with chemotherapy as a treatment for patients with late stage refractory Nasopharyngeal cancer, a type of head and neck cancer prevalent in China.

上海Sunway生物技术有限公司今天宣布，H101已获中国国家食品药品监督管理局批准。H101是一种溶瘤腺病毒，与化疗相结合用于晚期难治愈的鼻咽癌――中国国内的一种常见头颈癌――的治疗。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。