难以

The expression level of metabolitic enzyme (CYP1A1, CYP1B1) and its correlation with cell differentiation /apoptosis were studied as well. The influence of resveratrol in cell cycle was determined with FCM. Results 1 Resveratrol not only suppresses the growth of medulloblastoma cells in a dose and time related fashion but also induces cell differentiation and apoptosis. Resveratrol promotes differention of UW228-1,-2 cells to forward glia, UW228-3 and Med-3 cells to neuron. A treatment of resveratrol in the concentration of 100μM for 48hrs comit most of cells die of apoptosis. 2 Among the four cell lines Fas and Caspase-3 were constantly expessed, whereas FasL was absent irrespective to the drug treatment. 3 ICC, RT-PCR, Western-blot hybridization and EROD enzymatic activity assay demonstrated that expression of CYP1A1 is different after treatment with resveratrol in four cell lines, up-regulated in three UW228 cell lines in a dose dependent manner but down-regulated in Med-3 cells. Suppressive effect of resveratrol on CYP1B1 expression is the same among four medulloblatoma cell lines. 4 Cell cycle distribution of UW228-3 was greatly changed after treatment.

结果：1、白藜芦醇以时间和剂量依赖性方式抑制髓母细胞瘤细胞生长，同时促进细胞的分化和凋亡：白藜芦醇促使UW228-1、-2靶细胞向神经胶质细胞方向成熟分化，UW228-3、Med-3细胞向神经元细胞方向成熟分化，以100μM作用48小时效果显著；2、四个细胞系均有Fas和Caspase-3表达，但无Fas-L基因表达和蛋白活性产生，因此难以形成Fas相关性死亡通路；3、白藜芦醇处理前后CYP1A1基因的表达在各细胞系略有不同：UW228-1，-2，-3三个细胞系白藜芦醇以剂量相关性方式上调CYP1A1的表达，而Med-3细胞系，白藜芦醇却抑制CYP1A1的表达；四个细胞系在白藜芦醇处理后CYP1B1的表达均受到抑制；4、UW228-3细胞系经白藜芦醇作用后细胞周期有较大改变，表现在G0/G1期在整个细胞周期中所占的比例增加，而其它时期则相应减少。

Find a way to do it from command line.

找到一种方法，也难以从命令行。

As financial intermedium, mutual fund and market are not only competing with each other, but also commensal.

就是说，稳定性影响受到许多条件的制约，如果条件不具备，稳定性影响将难以发挥。

At present, the workers of the eighth oil plant use production logging method to determine single-layer's output and water cut of commingle producing well which produce Putaohua and Fuyu reservoir at the same time. This method takes a long period and high costs. And it's also difficult to determine single-layer's water cut. Aims at this problem, this present writer provides gas phase chromatogram fingerprint methods to determine single-layer's output.

针对目前采油八厂地区葡萄花、扶余两套合采油层采用生产测井方法确定分层产量及含水时成本高、周期长以及分层含水难以确定的问题，本文提出了应用气相色谱指纹技术来确定分层产量的方法。

The common perception is that stock market crashes are random and unpredictable phenomenon...

普遍的看法是，股市重挫是随机和难以预测的现象

The common perception is that stock market crashes are random and unpredictable phenomenon.

共同的看法是，股票市场的崩溃是随机和难以预料的现象。

However, the principles are still intuitive and commonsensible and thus can't explicitly reflect the inherent relationships between the goal and related research fields of green chemistry.

然而，上述原则主要是直觉和常识的结晶，难以清晰地反映绿色化学的目标和相关研究领域的内在联系。

At present medical disputes are hard to resolve. One important reason for this is that there is a lack of communicatory platform that both doctors and patients can trust.

摘 要：摘要：目前我国医疗纠纷难以解决的一个重要原因是医患双方缺乏可以相互信赖的沟通平台。

Because DC motor has commutator, it is limited to use. People took into account VC motor.

由于有换向器的存在，使直流电机的使用受到很大限制，于是人们开始转向异步电机，但异步电机的调速性能难以满足生产的要求。

This can be difficult to achieve in compact plants.

这可能是难以实现的紧凑型植物。

In the negative and interrogative forms, of course, this is identical to the non-emphatic forms.

。但是，在否定句或疑问句里，这种带有"do"的方法表达的效果却没有什么强调的意思。

Go down on one's knees;kneel down

屈膝跪下。。。下跪祈祷