隐球菌

Compounds (2),(3),(5) and (7) can inhibit the growth of pathogenic fungi Cryptococcus neoformans and Epidermophyton floccosum.

化合物（2）、（3）、（5）和（7）对病原真菌新型隐球菌和絮状表皮癣菌具有抑制作用。

A systemic infection caused by the fungus Cryptococcus neoformans that can affect any organ of the body but most often occurs in the central nervous system.

隐球菌病一种由新型隐球酵母真菌所致的全身性传染病，能够侵袭身体的任何器官，但多数通常出现在中枢神经系统中

However, fungal granulomas (histoplasmosis, cryptococcosis, coccidioidomycosis) can mimic this pattern as well.

然而真菌性肉芽肿（组织胞浆菌病，隐球菌病，球孢子菌病）也具有这样的外观。

Methods the diagnosis situation of 19 cases of cryptococcal meningitis who have been confirmed from 1980 to 2004 are analysed.results there are 17 misdiagnosis cases in 19 patients, of which 7 cases are tubercular meningitis,3 are viral meningitis,2 are brain tumor,1 is cerebral edema,1 is arachnoiditis of brain and 2 are others.conclusion misdiagnosis can be discreased by promoting learning about cryptococcal meningitis, examining the doubtful patients' csf frequantly and another examinations.

对本院1980—2004年确诊的19例新生隐球菌脑膜炎病人的诊断情况进行回顾分析。结果 19例确诊前有17例被误诊，其中误诊为结核性脑膜炎7例，脑肿瘤2例，病毒性脑膜炎3例，脑水肿1例，脑蛛网膜炎1例，红斑狼疮脑病1例，其他2例。结论提高对新生隐球菌脑膜炎的认识，对可疑病人多次做脑脊液墨汁涂片检查，或其他检查，可减少误诊。

In vitro this oil showed a better antifungal activities, under the concentration of 2.0 μL/mL in media it could totally inhabit the growth of Crytococcus neoformans, S porothrix schenckii, Microsporum lanosum, M. Gy pseum and Chaetomium globosum.

该挥发油具有一定的体外抗真菌活性，在培养基油浓度小于2.0 μL/mL的情况下，能够完全抑制新型隐球菌、申克氏孢子丝菌、羊毛状小孢子菌、石膏样小孢子菌和球毛壳霉等皮肤真菌的生长繁殖。

Com-pound 11 showed best antifungal activity with broad antifungal spectrum and proved to be more active against Cryptococcus neo-formans, C andida albicans, Microsporum lanosum and Trichophyton rubrum than ketoconazole.

化合物11的抗菌谱最广，抗真菌活性最高，对新型隐球菌、白色念珠菌、羊毛状小孢子菌和红色毛癣菌的抗菌活性比酮康唑高，有进一步开发的价值。

The range of organisms found is very wide and includes bacteria (Pseudomonas M. tuberculosis, E. coli), fungi (Aspergillus, Monilia, Cryptococcus). Viruses (Cytomegalo-Virus. Herpes zoster) and Pneumocystis carinii.

致病微生物的范围很广泛，包括细菌(假单胞菌属、结核杆菌，大肠杆菌)，真菌(曲霉属、念珠菌属、隐球菌属)，病毒及卡氏肺囊虫。

New antifungal agents have been developed over the past years based on the discovery of many new target sites of Candida albicands. For example, Echinocandins, aiming at the cell wall of Candida albicands, showed strong antifungal activities to fluconazole resistant candidas and fungal biofilm. Moreover, because β-glucan synthase does not exist on the cell membrane of mammalian cells, Echinocandins has a low toxicity and a promising clinical future. Though the mechanism of Histatin is not clear, it has strong activity not only on candida resistant of polyene and azole, but also to Candida parapsilosis, Candida krusei and Cry ptococcus neoformans. Berberine and Ocimum gratissimum L. were also found to have prominent anti-fungi activities.

近年来相继提出了许多抗白念珠菌药物作用的新靶点并成功开发出一些活性强大，疗效确切的抗真菌药，如以真菌细胞壁为靶点开发出棘白菌素类药物卡泊芬净、米卡芬净等，该类药物主要抑制β-葡聚糖合成酶，体外对氟康唑耐药的念珠菌属及真菌生物被膜表现出强大的抗菌活性，又由于β-葡聚糖合成酶在哺乳类动物细胞内不存在，故具有高效低毒的临床效果，是一极具前途的新型抗真菌药；以真菌细胞膜为靶点开发出Histatin类药物，虽然作用机制目前还不完全明了，但其作用不同于临床常用的多烯类和氮唑类，并已经发现Histatin5对两性霉素B和氮唑类耐药的念珠菌有效，并且对非白念珠菌如光滑念珠菌、克柔氏念株菌、隐球菌等也有杀灭作用；通过对植物药物的研究发现黄连素和丁香罗勒Ocimum gratissimum L。

Hylogenetic analysis indicated that PsCdc2 showed high similarity with Cdc2 from Puccinia graminis (73.1%), Cryptococcus neoformans (72.4%) and Ustilago maydis (70.4%), respectively.

sCdc2基因编码蛋白与小麦秆锈菌、新型隐球菌、玉米瘤黑粉菌等多种真菌的Cdc2高度相似，其中与小麦秆锈菌的Cdc2亲缘关系最近，序列相似性达73.1%。

All C.neoformans contain serine protease; Serine proteinase perturbs the integrity of BMEC of the blood-brain barrier, improves open the level of BBB; Secreted serine protease from pathogenic fungi were virulence.

发现新生隐球菌分泌具有活性的胞外蛋白水解酶并含有丝氨酸蛋白酶成分；新生隐球菌自身分泌的丝氨酸蛋白酶可以干扰构成血脑屏障主要成分内皮细胞的完整性使得血脑屏障开放程度提高；致病性真菌分泌的丝氨酸蛋白酶可能是一种毒性因子。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。