阿霉素

Results Stable drug-resistant SW1990/GZ cell strain was established by culturing with gemcitabine for 9 months. The morphology and growth characteristics of the cell strain changed remarkably. The cells shrinked and became rounder; its endoplasm expanded; granular substances increased; and the doubling-time was prolonged. Resistance of the cell line to gemcitabine, fluorouracil, adriamycin, and mitomycin significantly increased. The TrxR activity of the drug-resistant cells was increased markedly.

结果 药物培养9个月后，得到稳定传代的SW1990/GZ耐药细胞株；其形态学、生长特征等均发生了明显变化，细胞变圆、体积缩小、内质网扩张、颗粒样物质增多及细胞倍增时间延长；对吉西他滨、5-氟尿嘧啶、阿霉素和丝裂霉素的耐药性均显著增加；耐药细胞的TrxR活性也明显增高。

the objective of this study was to investigate the protection by apigenin against adriamycin-induced injury and its underlying mechanisms in normal blood cells.

小 摘要：本研究探讨芹黄素(apigenin，api)对化疗药阿霉素损伤正常血细胞的保护作用及其机制。

Thunberg Fritillary Bulb is one of the most popular Traditional Chinese herbs. Some trials in vivo and animals indicated that Peimine and Peiminine, extracted from Thunbery Fritillary Bulb, have the function of reversing MDR of two different kinds of mechanisms. They can improve the cytotoxic of ADR to cancer cells by 5～10 folds under concentration of 10% cancer cell growth inhibitory rate. Peimine and Peiminine not only feather typical character of modifier of MDR, but also differ from other moldifiers such as Calcium channel blocker, Cyclosporines in chemical structure, they belong to cevine groups alkaloid, a subgroup of C-Nor-D-homosteroid alkaloid.

浙贝母是临床常用中药，体外及动物试验证明，浙贝母中的有效活性成分贝母甲素和贝母乙素具有逆转肿瘤细胞MDR的作用，而且能逆转两种不同机制的多药耐药肿瘤细胞的耐药性，在无明显细胞毒剂量下，可使阿霉素对耐药肿瘤细胞的杀伤活性提高5-10倍，不但具备明确的多药耐药逆转剂的特征，而且在化学结构上属异甾类生物碱中的瑟文类生物碱，完全不同于钙离子拮抗剂、免疫抑制剂和其它现有的耐药逆转剂，具有作用靶点宽、化学结构独特的特点。

The expression of CyP gene from renal tissue in ADR nephropathy was significantly higher than the control.

阿霉素肾病肾组织环孢素亲合素基因表达比对照组明显增高。

It was one of the reason for renal tissue damage that the findings revealed the high level expression of CyP mRNA in ADR nephropathy, and reflected the grade or progress in ADR nephropathy.

说明阿霉素肾病肾组织高水平的环孢素亲合素基因表达是肾组织损伤的原因之一，对CyP 在自身免疫性疾病和器官移植排斥中的研究具有重要的理论与应用价值。

The objective of this study was to investigate the protection by naringenin against doxorubicin-induced oxidative damage in normal blood cells.

本研究探讨柚皮素对化疗药阿霉素损伤的正常血细胞的保护作用。

It is concluded naringenin can protect against doxorubicin-induced oxidative damage in normal blood cells.

柚皮素对阿霉素损伤的正常血细胞具有保护作用，其可能机制是柚皮素提高细胞内抗氧化物酶活性同时降低氧化产物含量。

The results indicated that the proliferation of K562 cells was not inhibited by the cytotoxicity of doxorubicin in combination of naringenin with doxorubicin.

结果表明：两药联合实验组（Post1小时组、Post24小时组）中，柚皮素无明显降低阿霉素对K562细胞的增殖抑制作用。

It was recently reported in Japan that effective component of the extract of Rubia Cordifolia L has obvious inhibition for leukemia, cancer of colon and carcinoma of the lung in mice, its curative effects equaled or exceeded to the catharanthine, mitomycin and adriacin and had less virulence for normal cells.

近来日本学者系川秀治等研究发现茜草提取物中的有效成分环己肽类化合物对小鼠的白血病、腹水癌、大肠癌、肺癌均有明显的抑制作用，其疗效等于或优于长春碱，丝裂霉素、阿霉素，并且对正常细胞的毒性低。

There was decreased methyl level of P53 exons (6, 7 and 8) following starvation of folacin, in the HBL-100, but not in the MCF-7 cell line.

MCF-7对阿霉素、顺铂、氟尿嘧啶（5-FU）、丝裂霉素和甲氨蝶呤等化疗药物均不敏感。

My first article for Screen Power Magazine, which is to this day is the official magazine of Jackie Chan, was a DVD review of the Hong Kong actioner Gen-X Cops, starring Nicholas Tse and Daniel Wu.

我的第一篇文章为屏幕力量杂志，在对这天是Jackie Chan 正式杂志，是香港actioner Gen X 警察的DVD 回顾，担任主角Nicholas Tse 和丹尼尔吴。

His lips grazed hirs, Now what are you going to do?

他的唇使吃草了 hirs，现在你将要做什麼？