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However, alkylating agents, such as cyclophosphamide, and the topoisomerase II inhibitors, doxorubicin and epirubicin, are associated with two types of cytogenetically distinct leukemias after adjuvant chemotherapy.

然而,烷化剂如环磷酰胺、拓扑异构酶II抑制剂、阿霉素、表阿霉素都与辅助化疗后的两种细胞遗传学不同的白血病的发生相关。

In this research work, the technology of microbial conversion was studied in order to establish an environment friendly method for the production of doxorubicin. A doxA gene encoding Daunorubicin C-14 hydroxylase was cloned from a daunorubicin-producing strain Streptomyces coeruleorubidus SIPI 1482. Some plasmids for the expression of doxA gene were constructed and transformed into S.

本研究对微生物转化法替代现有工艺生产阿霉素进行了探索,从柔红霉素产生菌天蓝淡红链霉菌SIPI 1482中克隆了柔红霉素C-14羟化酶基因,构建了doxA基因的链霉菌表达质粒,导入变铅青链霉菌TK24中获得了柔红霉素转化基因工程菌,并研究了doxA基因在工程菌中的表达,最后还对工程菌转化柔红霉素生成阿霉素的发酵工艺进行了初步研究。

Seriously escapes themedicine which sends to have the Arab League mildew element, the tableArab League mildew element, the ghost 臼 ethylidene glucoside (vp16)and so on.

较严重脱发的药有阿霉素、表阿霉素、鬼臼乙叉甙(vp16)等。

Methods MTT assay for detection of single use of Adriamycin and combination of Adriamycin with gleditsia saponin on the Role of the SMMC-7721 cell survival rate; detection of mRNA expression of bcl-2 by PCR method; detection of protein expression of bcl-2 by Western blotting method.

MTT法检测单独应用阿霉素阿霉素与皂角皂苷联合作用的SMMC-7721细胞的生存率;RT-PCR检测bcl-2 mRNA表达;Western blotting检测bcl-2蛋白的表达。

Observing localization of the drug and morphologic change in DRG cells and motor neurons in spinal cord anterior hom after 1% adriamycin intraneural injection into the sciatic nerve of rabbits. Moreover, evaluating sensory and motor function 1-8 weeks following injection. Exploring whether the agent, injected into sciatic nerve, has the effect of chemo-ganglionectomy on the corresponding DRG.

研究家兔坐骨神经内注射1%阿霉素后,药物的聚集部位及相应脊髓前角运动神经元和背根节细胞的形态学变化,测定家兔1~8周下肢感觉及运动功能,探讨坐骨神经内注射阿霉素能否对相应背根神经节产生化学切除术作用。

Observing distribution of the drug and it's effect on DRG cells after paravertebral injection with 0.1-1% adriamycin in rabbits. Investigating whether adriamycin entered selectively into DRG and damages DRG cells.

目的:1。研究家兔椎旁注射0.1~1%阿霉素后,药物的聚集部位及其对背根神经节细胞的影响,探讨阿霉素能否选择性进入背根神经节并损伤背根节细胞。2。

Methods: 47 patients with first bladder carcinoma after operation were divided two groups: the A group ( 23 cases) and B group (24 cases), and 52 patients with recrudescent bladder carcinoma after operation were divided two groups: the C group ( 26cases) and D group (26 cases), the patients in gro...

将47例初发性膀胱癌术后患者分为A(23例)和B(24例)二组,同时将52例复发性膀胱癌术后患者分为C(26例)和D(26例)二组。A、C组在术后6h内表阿霉素80mg/次单次灌注;B、D组在术后1周内表阿霉素50mg/次膀胱灌注,每周1次,共4次,后每月1次,共1年。

METHODS: Collaborative meta-analyses were undertaken of 194 unconfounded randomised trials of adjuvant chemotherapy or hormonal therapy that began by 1995. Many trials involved CMF (cyclophosphamide, methotrexate, fluorouracil), anthracycline-based combinations such as FAC (fluorouracil, doxorubicin, cyclophosphamide) or FEC (fluorouracil, epirubicin, cyclophosphamide), tamoxifen, or ovarian suppression: none involved taxanes, trastuzumab, raloxifene, or modern aromatase inhibitors.

对194个开始于1995年的关于辅助化疗或激素治疗的随机试验进行meta分析,许多试验包含了CMF(环磷酰胺、氨甲喋呤、氟尿嘧啶),蒽环药物为基础的联合化疗比如FAC(氟尿嘧啶、阿霉素、环磷酰胺)或FEC(氟尿嘧啶、表阿霉素、环磷酰胺)及他莫昔芬或卵巢去势;无一包含紫杉烷类、赫赛汀、雷洛昔芬及芳香化酶抑制剂。

The exact mechanism might be that adriamycin destroyed SP and CGRP gangliocytes in trigeminal ganglions to decrease SP and CGRP synthesis and release therefore to inhibit the transmittion of nociceptin stimulation.

我们认为,将阿霉素直接注入神经干后,通过轴浆的逆行运输作用,阿霉素可到达三叉神经节,并选择性地破坏相应的节细胞,起到&化学切断&的作用,阻断中枢神经系统与三叉神经周围支之间的信息传递,从而达到治疗三叉神经痛的目的。

Methods 30 SD rats were divided into three groups randomly: control group, ADR group and ADR+FDP group.

30只SD大鼠随机分为对照组、阿霉素组和阿霉素+1,6-二磷酸果糖组。

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