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Abstract〕 Objective To approach the feasibility of preparing dilated cardiomyopathy and heart failure models of animals with adriamycin.

目的:探讨应用阿霉素静脉注射的方法制备扩张型心肌病及心力衰竭模型的可行性。

The intracellular adriamycin of gastric cancer cells was determined using flow cytometry.

10借助流式细胞仪检测细胞内蓄积和潴留的阿霉素

Objective To evaluate the therapeutic effect of injection with adriamycin on trigeminal neuralgia of the second branch.

目的 确定与评价阿霉素治疗三又神经痛第Ⅱ支的临床疗效。

Methods: Utilizing cardiac toxicity of Adriamycin to make the model of congestive heart failure rats.

利用阿霉素的心脏毒性,诱导心力衰竭大鼠模型。

The results showed that GP (320 mg/kg) combined with ADM (2 mg/kg) could significantly prolong survival Lime of mice bearing SF763 tumor, the life-prolonging rate was 88%(P40 mg/kg) significantly had a inhibition no A549 (P.05), the optium dosage of GP was 80 mg/kg, which had an inhibition of 82.2%(P.01) after an inoculation of 11 days; GP had a negative relation on prolonging survival time of mice bearing EC tumors between dosage of GP and the effect. The optimum dosage was 5-10 mg/kg, which had optimum prolonging rate of 32.77%(P.05). Thus GP could significantly prolong survival time of mice bearing SF763, A549 and EC tumors.

结果表明:生药剂量320 mg/kg GP联合2 mg/kg阿霉素,其生命延长率为88%(P01),GP能明显延长荷人脑瘤SF763裸鼠生命;GP在大于40 mg/kg时对人肺腺瘤A549裸鼠具有明显的抑制作用(P.05),最佳剂量为GP 80 mg/kg,接种时间11d,抑瘤率为82.2%(P.01);GP对艾氏腹水瘤EC小鼠的生存期呈现负量效关系,GP最佳剂量范围在5~10 mg/kg,最高生命延长率为32.77%(P.05)。

Objective To evaluate the efficiency and safety of liposomal doxorubicin in the treatment of recurrent epithelial ovarian cancer.

目的 评价脂质体阿霉素在复发性卵巢上皮性癌二线化疗治疗中的有效性和安全性。

Abstract] Objective To evaluate the efficiency and safety of liposomal doxorubicin in the treatment of recurrent epithelial ovarian cancer.

摘要] 目的评价脂质体阿霉素在复发性卵巢上皮性癌二线化疗治疗中的有效性和安全性。

Half the women received a combination therapy of trabectedin and a chemotherapy drug called pegylated liposomal doxorubicin.

一半的女性接受trabectedin和称为脂质体阿霉素聚乙二醇的化疗药物组成的混合疗法。

In second-line drugs for the treatment of recurrent epithelial ovarian cancer,liposomal doxorubicin is more effective and well tolerated.

脂质体阿霉素在复发性卵巢上皮性癌二线化疗药物中有较高的疗效优势,且具有更好的安全性和可耐受性,楷莱可作为复发性卵巢上皮性癌非铂类化疗的理想选择。

V increased (other than Ara-C) and the inhibitory effect against 〓 improved significantly, especially for ADM. The empty pro-liposomes may undergo three process when hydrated with drug solution: swelling of phospholipid film, fracture of film and resealing to form vesicles.

以空白脂质体前体为载体,对几种临床上常用的抗癌药物的抑瘤活性及毒性进行了研究,研究结果得出:与游离药物相比,5-Fu,阿霉素等药物的抑瘤活性都有不同程度的提高;急性毒性实验表明:除Ara-C外,几种药物的毒性均有所降低,以顺铂最明显。

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