阿霉素

There were no significant difference between the concentration of DOX in livers and kidneys of every groups.

肠胃清在不影响正常组织阿霉素浓度的同时，通过增加阿霉素在肿瘤细胞内的积累而增强阿

The concentration of DOX in tumor and the apoptotic rate in cancer cell were all higher in DOX plus CWQ group than that in other groups.

结果 阿霉素和肠胃清单独给药均不能抑制肿瘤组织的生长，阿霉素与肠胃清联合能显著减少肿瘤组织的重量，增加肿瘤组织内的阿霉素浓度，诱导肿瘤细胞发生凋亡。

The mechanism of GCT restrained by ADM: To determine the mechanism of GCT restrained by ADM, the GCT cells were cul- tured with ADM (the dense of ADM after adding were 0.04μg/ml, 0.4μg/ml and 4μg/ml) for 72 hours. The GCT cell were observed by microscope and electron lens, analyzed by flow cell counter and DNA electrophoresis.

阿霉素抑制骨巨细胞瘤的机理：为探讨阿霉素抑制骨巨细胞瘤的机理，我们用阿霉素与骨巨细胞瘤细胞悬液共同培养72小时（阿霉素最终浓度分别为0.04μg/ml，0.4μg/ml及4μg/ml），搜集细胞，用光镜、电镜观察及用流式细胞仪、DNA电泳进行分析。

The double flourescent staining of apoptosis and expression of transforming growth factor β1 (TGF β1) were examined in liver tissue of animal pattern of ADR-injury by immunohistochemical and TUNEL,and the level of lipid peroxidation in serum was observed.

结果 阿霉素组大鼠肝组织可见细胞凋亡和肝细胞中转化生长因子β1的异常表达；阿霉素组大鼠血清中脂质过氧化物明显升高；亚硒酸钠对阿霉素的损伤有明显的保护作用。

Results DOX pre-conditioning and IP significantly decreased serum AST,ALT and LDH,furthermore interaction of DOX preconditioning and IP had statistical significance and associating application of the two methods decrease serum AST,ALT and LDH to a lower level.IP significantly decreased plasma ET and serum TNF-α;DOX and IP significantly increased serum NO;DOX preconditioning improved the expression of HSP70in liver.

结果 阿霉素预处理、缺血预处理、阿霉素+缺血联合预处理能明显抑制AST、ALT、LDH水平升高，其中以阿霉素+缺血联合预处理作用最显著；缺血预处理能显著降低ET、TNF-α水平；阿霉素预处理和缺血预处理使NO显著升高；阿霉素预处理能使肝细胞HSP70显著增加。

But injury of normal tissue is one of important factors which have to stop killing tumor cell thouoghly, in all process of tunor therapy Since the injury all over argans and cells of the body by free radical, especially significant side-effect to heart via ariblastine ,is universally accepted, we chose Adriamycin as chemical therapy medicine in our study.

由于阿霉素具有比较公认的自由基周身性损伤、特别是对心脏损伤的突出副作用，因此，本课题选择阿毒素作为化疗药物，模型制作采用在SD大鼠肝表面种植Walker－256瘤细胞株，于种瘤后第11天按2mg~(-1)kg体质量给单纯化疗组和化疗保护组的大鼠腹腔注射阿霉素，正常对照组和荷瘤对照组按相同比例腹腔注射生理盐水；同时，每日上午按0.5ml/100g体质量经胃给于化疗保护组抗氧化剂混合液，其余各组每日给于相同剂量的三蒸水；下午按0.1ml/100g体质量经胃给于化疗保护组维生素E溶液，其余各组每日给于相同剂量的处理过的油。

There is also evidence that Selenium has a protective effect against some forms of cancer; including lung cancer, colorectal cancer, prostate cancer, liver cancer , breast cancer, and so on common cancer. The trace element selenium has been shown enhance male fertility; decrease cardiovascular disease mortality, and regulate the inflammatory mediators in asthma; Treatment of secondary lymphedema of the arm with physical decongestive therapy and sodium selenite.

有证据对多种癌症，如肺癌、结直肠癌、前列腺癌、肝癌和乳腺癌等有防护作用；硒增强男性生育力，降低心血管病死亡率，控制哮喘病炎症介体；亚硒酸钠治疗癌症病人由于肿瘤、淋巴结切除或放疗后引起上臂肢体近端继发性淋巴结水肿；补硒可增强泰素和阿霉素的疗效，此疗效比单用泰素和阿霉素为好。

Aim:To observe the therapeutic effects of liposomeencapsulated adriamycinadministered into the hepatic artery for hepatoma in rats fand compare it with that of adriamycin solution and ADM plus blank liposome.

目的：观察阿霉素脂质体经肝动脉给药对大鼠肝肿瘤的疗效，并与阿霉素水溶液及阿霉素加空白脂质体相比较。

One group was given Adriamycin 3mg/kg to every rabbit, the other group was given GAMANP 61.49mg/kg to every rabbit, exsanguinated 1ml in each time, then separated serum and saved in low temperature,distill the Adriamycin with chloroform-carbinol, put it under the High Performance Liquid Chromatography to examine the special hromatogram apex height.

用还原胺化法制备半乳糖基人血白蛋白，及用加热固化法制备半乳糖化白蛋白磁性阿霉素纳米粒，家兔12只，随机分为两组，每组6只，均予颈静脉置管抽血，一组按3mg/kg给予阿霉素；一组按61.49mg/kg给予半乳糖化白蛋白磁性阿霉素纳米粒，每次抽血1ml，分离出血清，低温保存，用氯仿-甲醇液提取阿霉素，在高效液相色谱仪下检测色谱峰高。

LC3-FITC had been used to monitor autophagy by immunofluorescence. It showed that there are a high level of LC3 puncta in HCQ+DOX or BAF +DOX treated cells, and in rapamycin treated cells, moderate level in HCQ, BAF, or DOX singly treated cells, and low level in 3-MA+DOX, and there was diffuse fluorescence in untreated or 3-MA treated cells.

内源性LC3免疫荧光染色显示，羟氯喹+阿霉素、BAF+阿霉素及雷帕霉素处理组MM细胞胞浆可见大量颗粒状荧光，羟氯喹、BAF、阿霉素单用组仅有中等量颗粒状荧光，而3-MA及3-MA+阿霉素组胞浆荧光信号基本呈弥散分布，类似于未处理对照组。5。

Now, however, all children continue in "comprehensive" schools, and the eleven-plus determines which courses of study the child will follow.

然而现在，所有的孩子都要在综合学校继续学习，所以这次考试只是决定他们将要学习哪些课程。

Cultivatable land , and led to a general recognition that development must not be carried at the cost of agriculture .

城区的迅速扩大在很多情况下侵占了宝贵的可耕地，使人们普遍认识到发展不能以牺牲农业为代价。