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Because glial cell activation could also be involved in the development of opioid tolerance in rats, the authors studied the antinociceptive effects of ibudilast and morphine in different models of coadministration.

由于大鼠神经胶质细胞的激活也被证实与阿片样物质耐受性的产生有关,作者研究了异丁司特和吗啡在不同的共同给药模型中的镇痛作用。

The results indicate that BAM22 is involved in modulation of nociceptive processing at the spinal level under normal and inflammatory status.

结果表明:脊髓背角和DRG中的BAM22参与了伤害性信息的传递。也提示:BAM22可能是DRG传入纤维中枢端阿片受体和SNSR的内源性配体。

Methods Based on the index related to protopine, to investigate the effect of different aperture membrane and orthogonal test of separation parameters on membrane separation efficiency of Xiatianwu Injection.

采用不同截留分子的膜组件、操作参数进行正交设计,以与原阿片碱相关的各种指标考察不同膜组件及操作参数对膜分离效果的影响。

Future studies are required to examine therespective roles of supraspinal and peripheral sites of GBP-morphineinteraction and to investigate the mechanisms underlying theaction of GBP on opioid tolerance.

需要进一步的研究来检查 GBP -吗啡相互作用在脊髓以上和外周部位各自所起的作用以及研究解释 GBP 影响阿片类药物耐药性作用的机制。

The 3 pairs of primers for kappa opioid receptor gene were designed to analyze single nucleotide polymorphisms in partial coden region by PCR-SSCP.

用3对引物通过PCR-SSCP的方法对猪的κ阿片受体基因的部分编码区进行扫描,发现1个多态位点(GenBank登录号:AY130756)。

I try to view these soundbites as a new form of language- haiku versus open verse, a Zen fountain versus a mountain stream, flowers in a windowsill box versus a field of poppies ready to take you to a land deep in the opiated imagination.

我认为这些尝试头条作为一种新形式的语言与开放的俳句诗,禅喷泉与山溪水,鲜花在窗台上盒与实地罂粟愿意带你到一个深的土地阿片想象力。

Experiment 1, let rats acquire taste preference to quinine solution, and take account of β-EP-immunoreactive neurons in different nucleuses of hypothalamic areas, separately adopted taste preference learning training and immunohistochemistry; Experiment 2, Added banana essence into quinine solution to discuss the connection between flavor preference learning and the expression of β-EP; Experiment 3, To research endogenous opiate like substances contribute to the establishment of CTP and influence the behavior of taste preference by naloxone was i.p.

实验一,采用味觉嗜好学习训练和免疫组织化学方法,让大鼠获得对奎宁的味觉嗜好,计数了下丘脑不同核团内β-内啡肽免疫反应细胞数;实验二,向奎宁溶液中加入香蕉气味,探讨风味嗜好学习与下丘脑β-内啡肽表达的关系;实验三,腹腔内注射纳络酮,探讨内阿片肽对CTP建立及味觉嗜好行为表达的影响。

The codons encoding a tag of six consecutive histidines was added to 3'-end of human μOR cDNA by polymerase chain reaction with primer pair 5'-AATACG ACTCACTATAG-3' and 5'-AAAGGTCGACTAATTATCATTAGTGATGGTGATGG TGATGGGGCAACGGAGCAGTTTCTGC-3'.

本研究通过PCR方法在人μ阿片受体cDNA的3'端锚定编码六个连续组氨酸的密码子,PCR产物亚克隆人质粒载体pBluescriptⅡKS+/-的Hind Ⅲ/Sal Ⅰ位点。

Significant reduction of the postoperative opioid requirement and/or postoperative pain were defined as main rating criteria.

将术后阿片类镇痛药的需要量显著降低和/或术后疼痛的显著减轻定为主要的分级标准。

A: Patients with advanced illness may have constipation due to opioid use, immobility, decreased oral intake, a low-fiber diet, metabolic and endocrine imbalances, neurologic disorders, concomitant drug side effects, inadequate toileting arrangements, sedation, depression, and advanced age.

处于疾病进展期的病人导致便秘的常见原因有:阿片样物质的使用,缺乏运动,摄食减少,低纤维饮食,代谢及内分泌失衡,神经系统紊乱,药物副反应,入厕时间不足,镇静,抑郁以及高龄。

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