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BACKGROUND: Immersive virtual reality is a novel form of distraction analgesia, yet its effects on pain-related brain activity when used adjunctively with opioid analgesics are unknown.

背景:沉浸式虚拟现实是一种通过分散注意力达到镇痛作用的新方法,然而,它和阿片类药物联合应用对疼痛相关大脑活动的影响尚不得而知。

AIMTo further elucidate the role of agmatine on the pharmacological effects of opioids.

目的进一步阐明胍丁胺对阿片药理作用的影响。

The mechanism of regulation of agmatine on opioid dependence is related to the reverse effect on the NMDA receptors' level and construction.

胍丁胺调节阿片依赖可能与其逆转吗啡对NMDA受体亚基数量和构成的调节有关。

Objective Morphine is a representative of the opium antalgesic which mainly acts on the central nervous system.

目的 吗啡是阿片类镇痛药的代表,主要作用于中枢神经系统。

We must change the concept of cancer pain management medical model:Anesthetists should have professional abilities、 capability of health care and prevention、 ability of group cooperation、ability of assessment of new technology ,eliminate fear of addiction on using opioids ;implement interdisciplinary comprehensive appeasement health protection;applyment new technology;.

麻醉科医师必须明确在晚期癌痛治疗转变中的责任和义务:具有专业能力、保健与防病能力,消除使用阿片类药物成瘾恐惧症;团队协作能力、新技术的评估能力,实行跨学科综合姑息保健;遵循生物心理社会医学模式,对晚期癌痛患者实施人文关怀。

Methods TASMCs were stimulated with LPS in the presence or absence of CCK-8 and/or PKC inhibitor chelerythrine, morphine,-OR mRNA expression was analyzed by RT-PCR 16h after stimulation.

培养大鼠TASMCs,在加入或不加入CCK-8和/或CHE、吗啡的情况下,用LPS刺激细胞16h,用半定量RT-PCR检测κ阿片受体mRNA的表达。

Till today, we have extracted and purified alkaloids from from Macleaya Cordata, Chelidonium Majus L., Tripterygium Wilfordii Hook f., Sedum Sarmentosum Bunge, and obtained pure sanguinarine, ethoxysanguinarine, oxysanguinarine, chelidonine, chelerythrine, ethoxychelerythrine, chelilutine, chelirubine, protopine,α-allocryptopine,β-allocryptopine, coptisine, berberine, corysamine, bocconine; triptolide, tripdiolide, triptonide, wilforddine; N-methylisopelletierine, dihydro-N-methylisopelletierine, sarmentosin etc.

我们对博落回、白屈菜、雷公藤、垂盘草等天然植物进行了大量的提取和分离研究;并分离出了血根碱、乙氧基血根碱、氧化血根碱、白屈菜碱、白屈菜红碱、乙氧基白屈菜红碱、白屈菜黄碱、白屈菜玉红碱、原阿片碱、α-别隐品碱、β-别隐品碱、黄连碱、小檗碱、沙明碱、博落回碱,雷公藤内酯醇、雷公藤内酯二醇、雷公藤内酯酮、雷公藤碱,N-甲基异石榴皮碱、二氢- N-甲基异石榴皮碱、垂盘草甙等单体。

Methadone, Commonly Used as Maintenance Medication for Outpatient Treatment of Opioid Dependence, Kills Leukemia Cells and Overcomes Chemoresistance

通常用于阿片依赖患者门诊治疗的维持药物的美沙酮,可以杀死白血病细胞和克服耐药性

Because glial cell activation could also be involved in the development of opioid tolerance in rats, the authors studied the antinociceptive effects of ibudilast and morphine in different models of coadministration.

由于大鼠神经胶质细胞的激活也被证实与阿片样物质耐受性的产生有关,作者研究了异丁司特和吗啡在不同的共同给药模型中的镇痛作用。

Kappa opioid receptor gene of the Duroc breed was more polymorohic, while Yorkshire showed small diversity.

阿片受体基因在杜洛克猪种中表现较大的变异性,在大白猪种中变异相对较小。

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