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Objective:To study the effects of atrial fibrillation on the expression of κ-opioid receptor.

目的:观察心房纤颤对心房κ-阿片肽受体mRNA表达的影响。

In order to find novel analgesic agents with high activity and much lower toxicity, we designed and synthesized some new gluco, amino acids and glyceride derivatives of epibatidine.

详细Epibatidine是近年来发现的一个镇痛作用极强,且非阿片作用机制的生物碱。但由于它的毒性太大而不能成为临床用药。

It is known that either in vivo or in vitro, opioids can depress the secretion of gonadotropin.

已知在整体和离体条件下,阿片类物质抑制促性腺激素的分泌。

These results suggest that μ- and κ-opioid receptors in the guinea-pig ileum are dissociative.

这些结果表明豚鼠回肠中μ、κ阿片受体是分离的。

Cross-dependence and cross-tolerance of opioids in the guinea-pig isolated ileum are studied.

研究了阿片类药物在豚鼠离体回肠中的交互依赖性和交互耐受性。

Today, we call this opioid-induced hyperalgesia, or OIH.

" "今天,我们将此称为阿片类药物引起的过敏,或马尿酸钠。

According to the above results, we may conctude that SNP of KOR gene has effect on the still standing behavioral trait of sows.

因此,推测Kappa阿片受体基因SNP对母猪静止站立行为性状存在一定的影响

Spinal Opioid Receptor Like1 Receptor Agonist, but Not N -Methyl-D-Aspartic Acid Antagonist, Reverses the Secondary Mechanical Allodynia Induced by Intradermal Injection of Capsaicin in Rats

脊髓阿片样受体1激动剂,而非 N-甲基-D-天门冬氨酸拮抗剂,逆转大鼠皮内注射辣椒素引起的继发性机械性异常性疼痛

In the present study, weclarify the capsaicin concentration dependency for developmentand maintenance of secondary mechanical allodynia and the roleof spinal opioid receptor like1 (ORL1) receptor and N -methyl-d-aspartatereceptor in the development and maintenance of secondary mechanicalallodynia induced by an intradermal capsaicin injection. Capsaicin50 L of 0.03% induced the most intense secondary mechanicalallodynia.

在这个实验中,作者研究皮内注射辣椒素与继发性机械性异常性疼痛的相关性和脊髓阿片受体相关1受体激动剂( ORL1)和 N-甲基-D-天门冬氨酸受体在皮内注射引起的继发性机械性异常性疼痛的发生和维持中的作用。0.03%的辣椒素50uL 导致最强的异常性疼痛。

Long-term usage of opiates eventually leads to drug addiction, which is believed as a brain disease involved maladaptive changes in brain function.

长期使用阿片类药物可以导致药物成瘾。药物成瘾被认为是一种脑神经疾病,与大脑功能的适应性改变有关。

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