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Increasing evidence suggests that opiates can alter the functions of glutamatergic system.

越来越多的证据表明,阿片类药物所引起的这种适应性变化会影响突触前神经递质的释放,并改变包括谷氨酸能神经系统在内的神经元的功能。

Objective:To investigate the effects of caffeine on the rewarding effects of opiates using morphine conditioned place preference in rats.

目的:本文以大鼠条件性位置偏爱为模型,探讨咖啡因对阿片类物质奖赏效应的影响。

Furthermore, cholinergic neurons have been implicated in addiction to opiates and alcohol and in physiologic dependence and withdrawal syndromes.

而且,胆碱能神经元与阿片和酒精的成瘾性、生理依赖性和戒断综合征均有关。

Although opiates have been long advocated for the suppression of cough, there are few trial data to support this recommendation.

尽管阿片类制剂很早就被提倡用于治疗咳嗽,但一直没有太多的试验依据来支持。

Experiment 1, let rats acquire taste preference to quinine solution, and take account of β-EP-immunoreactive neurons in different nucleuses of hypothalamic areas, separately adopted taste preference learning training and immunohistochemistry; Experiment 2, Added banana essence into quinine solution to discuss the connection between flavor preference learning and the expression of β-EP; Experiment 3, To research endogenous opiate like substances contribute to the establishment of CTP and influence the behavior of taste preference by naloxone was i.p.

实验一,采用味觉嗜好学习训练和免疫组织化学方法,让大鼠获得对奎宁的味觉嗜好,计数了下丘脑不同核团内β-内啡肽免疫反应细胞数;实验二,向奎宁溶液中加入香蕉气味,探讨风味嗜好学习与下丘脑β-内啡肽表达的关系;实验三,腹腔内注射纳络酮,探讨内阿片肽对CTP建立及味觉嗜好行为表达的影响。

The patients had received conservative and surgical therapiesin the past including oral antidepressants, membrane stabilizers,opioids, occipital nerve blocks, and radiofrequency ablations.

这些病人过去接受过保守和手术治疗,包括口服抗抑郁药,膜稳定剂,阿片类药物,枕部神经阻滞和射频消融术。

The results of central microinjection of anti-endogenous opioids antisera provide further evidence for the hypothesis.

脑内微量注射三族内阿片肽抗血清的结果,为此提供了进一步的佐证。

Rabbits were equipped with intracerebral cannulae directing to two of the four nuclei.

我们在研究吗啡的中枢作用部位时发现,注射微量吗啡到家兔或大鼠的PAG、伏核、杏仁核或缰核内,可产生明显的镇痛作用;而将阿片受体阻断剂纳洛酮注入上述任一核团内,则能大部取消静脉注射吗啡产生的镇痛或电针引起的镇痛。

The technology of separation and purification of the interesting protein was studied, centrifuge the sample and get the clear supernatant, remove protein by 50% ethanol, concentrate by drying with freezing way, remove salt and pigment by dialysing, separation with G-50 and CM-cellulose52 column, concentrate by PEG6000, The purified sample was a single band after separation by SDS-PAGE.

研究了目的阿片肽的分离纯化工艺。发酵混合物经过离心取上清,乙醇沉淀去蛋白,冷冻干燥浓缩,透析除盐脱色,聚乙二醇6000反渗透浓缩,G-50柱分离,CM-cellulose52阳离子交换层析,聚乙二醇6000浓缩等步骤后得到了较纯的目的产物,目的产物在SDS-PAGE上呈现单一条带。

In this experiment, lymphocyte was infected with simian immunodeficiency virus and the influences of opioids (morphine and methionine enkephalin) were observed.

本项目用猴免疫缺陷病毒感染淋巴细胞,观察阿片类物质和SIV对细胞的影响。

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