阿朴吗啡

At baseline and on day 1, 3, 7, 14, 21 following MPP+ injection, the degree of microglial activation was examined by detecting the immunodensity of OX-42 in the substantia nigra. The number of viable dopaminergic neurons was determined by measuring tyrosine hydroxylase positive neurons in the SN. Behavioral performances were evaluated by counting the number of rotations induced by apomorphine, calculating scores of forelimb akinesia and vibrissae-elicited forelimb placing asymmetry.

分别在基线、MPP+注射后第1、3、7、14、21天时通过测定黑质区域OX-42的免疫荧光强度评定小胶质细胞的激活程度，测定酪氨酸羟化酶的表达情况评定存活多巴胺神经元的数量；通过阿朴吗啡诱导的旋转行为、前肢跨步及触须引发的不对称放置试验得分测评行为学表现。

MIAN OUTCOME MEASURES:①the circles of rat's rotation provoked by apomorphine.

主要观察指标：①各组大鼠在阿朴吗啡诱导下的旋转圈数。

Methods The diabetes mellitus rat model was induced by streptozotozin, and then apomorphine was administrated to set ED diabetes model.

采用链脲佐菌素制备高血糖大鼠模型，选择符合要求的模型再用阿朴吗啡诱导，筛选出符合最终造模要求的糖尿病ED大鼠模型。

Methods:All of 40 male Sprague-Dawley rats were divided into 3 groups:control group（group A, n = 10）, diabetic group for 4 weeks（group B, n = 14）, and diabetic group for 12 weeks（group C, n = 16）. The diabetes model was established by the injection of STZ. After some weeks erection function was examined by apomorphine injection. The content of NF-κB in the erectile tissue was evaluated by immunohistochemistry staining. At the same time the activity of NF-κB was detected by electrophoretic mobility shift assay.

将成年雄性SD大鼠40只分为3组：A组为正常对照组（10只），B组为糖尿病4周组（14只），C组为糖尿病12周组（16只），采用腹腔注射STZ法制作糖尿病模型。B组大鼠于4周后，A组、C组大鼠于12周后通过注射阿朴吗啡后评价勃起功能，并取阴茎海绵体组织免疫组化EnVision法分析NF-κB的分布与表达，同时采用电泳迁移率变动分析法进行NF-κB 活性检测。

Methods All of 40 male Sprague-Dawley rats were divided into 3 groups: control group (group A, n=10), diabetic group for 4 weeks (group B, n=14), and diabetic group for 12 weeks (group C, n=16). The diabetes model was established by the injection of STZ. After some weeks erection function was examined by apomorphine injection. The content of NF-κB in the erectile tissue was evaluated by immunohistochemistry staining. At the same time the activity of NE-κB was detected by electrophoretic mobility shift assay.

将成年雄性SD大鼠40只分为3组：A组为正常对照组（10只），B组为糖尿病4周组（14只），C组为糖尿病12周组（16只），采用腹腔注射STZ法制作糖尿病模型。B组大鼠于4周后，A组、C组大鼠于12周后通过注射阿朴吗啡后评价勃起功能，并取阴茎海绵体组织免疫组化EnVision法分析NF-κB的分布与表达，同时采用电泳迁移率变动分析法进行NF-κB活性检测。

Aim To observe the c-fos expression in the caudate-putman of 6-OHDA-lesioned rats after Apomorphine intraperitoneal injection and to investigate the inherent mechanism of it.

目的观察6-羟基多巴胺（6-OHDA）毁损黑质后，不同时间点腹腔注射阿朴吗啡大鼠纹状体c—fos表达情况，探讨其可能机制。

Methods Turning tests induced by apomorphine and forelimb functional tests were performed. Also, the expression of TH mRNA in mesencephalon of the rats was detected by semi-quantitative analysis of one step RT-PCR.

利用阿朴吗啡诱发旋转试验和前肢功能试验，检测PD大鼠的神经行为学特点，一管法逆转录聚合酶链反应半定量检测其中脑TH mRNA的表达。

After a two-week screening period, 18 patients participated in a four-week as-required regimen of 2 mg apomorphine SL, escalated to 3 mg when appropriate after two weeks. Three patients (16.7%) benefited from this treatment modality ( P .05). The nonresponding group of 15 patients continued with a daily regimen of 2 mg apomorphine SL for two weeks followed by 3 mg daily for two weeks. The 3 mg daily regimen was more effective for ED ( P .02) and for each sexual domain scored with the International Index of Erectile Function questionnaire. Adverse events, as reported by three patients (23%) during the 3 mg regimen, were nausea, dizziness, and headache.

在二星期的筛检过程之后，18位病患参与为期四个星期的2mg，在两星期后适当的增加至3mg的阿朴吗啡 SL疗法，其中三位病患(16.7%)受益于这种治疗方法(P 。05)，15位无反应的病患持续接受每日2 mg的阿朴吗啡 SL两周后，再接著以每日3 mg的两周治疗，对于ED及国际勃起功能指数调查表的每项性功能区计分，每日3 mg的疗法比较有效(P 。02)，在接受3 mg疗法期间三位病患( 23%)的不良事件，为恶心、眩晕、和头痛。

In addition, an expression of c-fos gene could be induced in the caudate putamen by injection of apomorphine from the rats survived 2 months in the experiment group.

免疫组化染色结果表明：6-OHDA损毁7 d，损毁侧TH阳性神经元及强阳性神经元较正常侧数目明显减少（P＜0.05），但阿朴吗啡不能诱导c-fos表达。

The rotations of PD rats induced by apomorphine could be inhibited by injection of CCK-8 into venous and nucleus accumbens of the lesioned sides.

静脉注射CCK-8及损毁侧伏核微量注射CCK-8可抑制PD大鼠模型由阿朴吗啡诱导的旋转行为，这种作用由CCK-A受体介导。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐