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阿托品

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Methods Animal models were made by binocular and monocular chronic atropinization.

用幼猫双眼或单眼慢性阿托品化的方法,造成屈光不正或屈光参差的弱视动物模型,在整个视觉发育期,连续检测其条栅视力和对比敏感度函数,并与正常幼猫相比较。

Key words] pesticide poisoning;first aid,nursing;atropinization

关键词]有机磷农药中毒;急救与护理;阿托品

Key words] pesticide poisoning;first aid,nursing;atropinization

关键词]有机磷农药中毒;急救与护理;阿托品化字串5

Washing the stomach completely early,attend and observe conscientiously after atropinization and perfect the comprehensive care measures are the keys to improve the curing rate of acute organophosphorus toxicosis.

早期彻底洗胃,对阿托品化后认真护理观察,完善综合护理措施是提高急性有机磷中毒患者抢救成功率的关键。

Tetrodotoxin selectively blocks the neuromuscular electrical activity, producing the effect of nondepolarizing curine and leading to failure of the respiratory drive without compromising the respiratory center.

河豚毒选择阻断神经与肌肉的电生理活动,呈非去极化型箭毒碱样作用,致呼吸动力障碍,与呼吸中枢无关,M胆碱能受体阻滞剂阿托品及中枢兴备剂均无明确使用指征,维持有效通气等综合治疗可达到满意疗效。

First 27 rabbits of the experimental group were destabilizated by operated on L6、7.Inj Diazepam 0.25 mg/kg,Inj Ketamine 0.02 g/kg and Inj Atropine 0.125 mg/kg was one by one injected into the rabbit through the auris vein,shearing the rabbit hair of backside waist,fixing the rabbit on operation table in face lying,using 1% Povidone Ioding to degerm the operation area.Every rabbit was incised at the backside of its waist,that incisal opening is located in the center of the intervertebral space (L6、7 space) that both side iliac crest line correspond ,from the meso-ordinate direction cut about 4 cm incision,cutting open skin and subcutaneous tissue,thoroughly ,exposing the spinous processes the vertebral plates and the upper-inferior articular processes,entirely segregating the muscles that cohere the spinous processes the vertebral plates and the articluar process,then excising the supraspinal ligaments and interspinal ligaments,biting off two sides the inferior articular processes of L6,in order that resulting in intervertebral destabilization,using 0.9% Inj.Sodium Chloride to washout the incisal opening,in order sewing up each layer tissues.

方法] 取48只6个月龄日本大耳白兔,雌雄不限,体重为(2.5±0.2) kg,随机进行分组,分为对照组和实验组,对照组为21只;实验组为27只;先将实验组兔腰背部皮毛剪除,用安定注射液1.25 mg/kg、氯胺酮0.02 g/kg、阿托品0.125 mg/kg顺次耳缘静脉注射麻醉后,俯卧固定于手术台上,用1%碘伏消毒手术区域,以髂嵴平对椎间隙(即L6、7)为中心,从正中取一长约4 cm纵行切口,切开皮肤及皮下组织,锐性分离,暴露棘突、椎板及上下关节突,将附着于棘突、椎板及小关节的肌肉全部分离开,然后依次切除L6、7棘上及棘间韧带,咬除第6腰椎两侧下关节突,造成椎间失稳,用无菌生理盐水冲洗切口,依次缝合各层组织;术后动物在笼中自由活动。

Inj Diazepam 0.25 mg/kg,Inj Ketamine 0.02 g/kg and Inj Atropine 0.125 mg/kg was one by one injected into the rabbit through the auris vein,shearing the rabbit hair of backside waist,fixing the rabbit on operation table in face lying,using 1% Povidone Ioding to degerm the operation area.Every rabbit was incised at the backside of its waist,that incisal opening is located in the center of the intervertebral space (L6、7 space) that both side iliac crest line correspond ,from the meso-ordinate direction cut about 4 cm incision,cutting open skin and subcutaneous tissue,thoroughly ,exposing the spinous processes the vertebral plates and the upper-inferior articular processes,entirely segregating the muscles that cohere the spinous processes the vertebral plates and the articluar process,then excising the supraspinal ligaments and interspinal ligaments,biting off two sides the inferior articular processes of L6,in order that resulting in intervertebral destabilization,using 0.9% Inj.Sodium Chloride to washout the incisal opening,in order sewing up each layer tissues.

方法] 取48只6个月龄日本大耳白兔,雌雄不限,体重为(2.5±0.2) kg,随机进行分组,分为对照组和实验组,对照组为21只;实验组为27只;先将实验组兔腰背部皮毛剪除,用安定注射液1.25 mg/kg、氯胺酮0.02 g/kg、阿托品0.125 mg/kg顺次耳缘静脉注射####后,俯卧固定于手术台上,用1%碘伏消毒手术区域,以髂嵴平对椎间隙(即L6、7)为中心,从正中取一长约4 cm纵行切口,切开皮肤及皮下组织,锐性分离,暴露棘突、椎板及上下关节突,将附着于棘突、椎板及小关节的肌肉全部分离开,然后依次切除L6、7棘上及棘间韧带,咬除第6腰椎两侧下关节突,造成椎间失稳,用无菌生理盐水冲洗切口,依次缝合各层组织;术后动物在笼中自由活动。

Objective To investigate the effect of using massage by finger pressing to prevent the enteroparalysis which caused by continue atropine injection.

目的探讨指压按摩法防治持续注射阿托品致肠麻痹的效果。

Patient of complete hemp of methodological choice adult 34 ASA1-2 class, random cent asks peaceful group and atropine group to grow, observe its vein uses medicine to be reached to the influence of the heartbeat control rate of gland body excretive, record the case that fights with the mouth after medicine.

方法选择成人全麻患者34例ASA1-2级,随机分为长托宁组和阿托品组,观察其静脉用药对心率的影响及抑制腺体分泌的程度,记录用药后口干的情况。

It was concluded that the effects of administration of YT by ip and endermosis is contrary to that of administration by po.The Neostigmine-induced hyperperistalsis of the small intestine was inhibited and the inhibitory effect of Atropine enhanced by ip and sc administration of YT suggesting the mechanism of YT involved the antagonism of Ach. But the contraction of isolated rabbit ileum was not inhibited by YT.

对于羊蹄叶水提取物抗腹泻作用机制的研究表明,腹腔注射、皮肤给药YT可明显抑制新斯的明所致小鼠小肠推进功能亢进,也可加强阿托品抑制小鼠小肠推进运动的作用,从而表明YT的作用机制可能与Ach有关,但家兔小肠离体实验表明YT对Ach所致家兔小肠收缩无明显的抑制作用。

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