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阻断剂

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AIM: To observe the effect of endothelin receptor antagonist (BQ123) on calcification in rat vascular smooth muscle cells in vitro. METHODS: Calcification of cultured rat VSMCs was produced by incubation with β-glycerophosphate.

目的:在离体钙化的血管平滑肌细胞上,观察内皮素受体阻断剂对血管平滑肌细胞钙化的影响,探讨内皮素促进细胞钙化的信号转导和分子机制。

METHODS:Calcification of cultured rat VSMCs was produced by incubation with β-glycerophosphate. Calcium content, Ca2+ deposition and alkaline phosphatase activity were analyzed to estimate the extent of calcification.

目的:在离体钙化的血管平滑肌细胞上,观察内皮素受体阻断剂对血管平滑肌细胞钙化的影响,探讨内皮素促进细胞钙化的信号转导和分子机制。

These results indicate that both the two methods of hypothermy resuscitation and octanol resuscitation can protect the lung on severe hemorrhagic shock with lung injury rabbits, and suggest that GJs play an important role in suspended animation to treat hemorrhagic shock with lung injury.

结论低温及辛醇延生复苏的效果显著优于传统复苏,缝隙连接阻断剂可产生与低温相似的肺保护效果,缝隙连接在重度失血性休克兔缺血性肺损伤延生复苏中具有重要作用。

Chloride channels have been identified in vasucular smooth muscle cells. These channels have been shown to be involved in myogenic tone regulation and neuromuscular transmission in various vascular beds. However, whether the chloride channels are responsible for the formation of excitatory junction potentials of the smooth muscle cells in the spiral modiolar artery remains elucidated.

许多研究已证实,血管平滑肌细胞膜上存在氯离子通道,进一步研究发现氯离子通道不仅参与调节平滑肌细胞的肌原性紧张,而且参与了许多种类血管床的神经平滑肌细胞之间的信息传递,但Cl-通道及氯离子通道阻断剂对耳蜗螺旋动脉细胞兴奋性接头电位(excitatory junction potential,EJP)是否有影响,目前还不清楚。

In the present study, the effects of chloride channels blockers,(Niflumic acid,NFA;IAA-94;DIDS) on EJP were explored in guinea pigs, using intracellular recording techniques on acute isolated spiral modiolar artery.

本实验运用细胞内微电极记录技术,在豚鼠耳蜗螺旋动脉(spiral modiolar artery, SMA)离体标本上,研究氯通道阻断剂(Niflumic acid, NFA; IAA-94; DIDS )对去甲肾上腺素引起SMA平滑肌细胞的反应和平滑肌细胞EJP的影响。

Our results showed that the RnR was localized in the perinuclear zone and plasma membrane of the MCs.

本文旨在观察RnR在体外培养的大鼠肾小球系膜细胞(mesangial cells, MCs)和肾脏中是否表达,及其表达的细胞部位,并用RnR的多肽阻断剂肾素原&柄区肽&(handle region peptide, HRP)与RnR结合后观察受体复合物进入细胞的过程与定位。

Cent of 玀 HCC97H cell is contrast group of group, HGF group, brilliant mildew vegetable, reach Western Blot with RT-PCR respectively the metabolic circumstance of afore-mentioned target albumen after change of level of Sp1 of analysis and VEGF MRNA, protein expression and Sp1 level, phosphation and applied Sp1 block break element of agent brightness mildew.

将MHCC97H细胞分为对照组、HGF组、光辉霉素组,分别用RT-PCR及Western blot分析和VEGF mRNA、蛋白质表达及Sp1水平、磷酸化Sp1水平变化以及应用Sp1阻断剂光辉霉素后上述目标蛋白的变化情况。

Eight patients continued to receive oxaliplatin therapy after prophylactically treatment with the antiallergic drugs, such as steroids, and 4 patients among them didn't suffer from allergic reactions any more.

其中8例患者在后续治疗中应用奥沙利铂前,使用5-羟色胺受体Ⅰ阻断剂和糖皮质激素等抗过敏药物,4例未再出现过敏反应。

Objective To study the effects of CTLA4-Ig on mu rine allergic contact dermatitis.

目的探讨B7/CD28共刺激通路阻断剂CTLA4-Ig对变应性接触性皮炎的作用。

Microinjection of norepinephrine (NE, 30 nmol) into the subnucleus commissuralis of nucleus tractus solitarii of rabbits evoked a decrease of mean arterial pressure and heart rate. These effects were attenuated by application of naloxone (3 nmol) on the same area,which by itself showed no effect on MAP and HR.

于杂种白兔的孤束核联合亚核内微量注射去甲肾上腺素,引起血压降低和心率减慢,将小剂量阿片受体阻断剂纳洛酮注入CNTS,本身不影响血压与心率,但减弱NE在CNTS中的降压降率幅度。

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Finally, according to market conditions and market products this article paper analyzes the trends in the development of camera technology, and designs a color night vision camera.

最后根据市场情况和市面上产品的情况分析了摄像机技术的发展趋势,并设计了一款彩色夜视摄像机。

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只有半人深的荒草和龇牙咧嘴的神像。

This dramatic range, steeper than the Himalayas, is the upturned rim of the eastern edge of Tibet, a plateau that has risen to 5 km in response to the slow but un stoppable collision of India with Asia that began about 55 million years ago and which continues unabated today.

这一引人注目的地域范围,比喜马拉雅山更加陡峭,是处于西藏东部边缘的朝上翻的边框地带。响应启始于约5500万年前的、缓慢的但却不可阻挡的印度与亚洲地壳板块碰撞,高原已上升至五千米,这种碰撞持续至今,毫无衰退。