阻断剂

Electively targeting of signaling pathways using protein kinase inhibitors would have a potential advantage over receptor blockers.

这种用来选择性地阻断信号转导途径的蛋白激酶抑制剂可能是一种潜在的有利的受体阻断剂。

MethodsThe electric potentials of isolated ventricular papillary muscle were intracellularly recorded. Electrophysiological parameters were: resting potential, amplitude of action potential, maximal rate of depolarization of phase 0, duration of action potential, duration of 50% and 90% depolarization (APD50 and APD90). The effects and mechanisms of action EVFP on the electric potentials were observed.

方法采用玻璃微电极细胞内纪录方法，描记麻黄果多糖对心室乳头肌静息电位，动作电位幅值，0相最大除极速度、复极至50%和90%(APD50，APD90)的时间的影响，并利用M受体阻断剂和β受体阻断剂，探讨其作用靶点。

In another series of experiments, we have observed that the effects of i. t. picrotoxin (PTX, a non-competitive GABA〓-receptor antagonist), or bicuculline (BIC, a competitive GABA〓 receptor antagonist), on the antinociception produced by i. t. NE, 5-HT or a GABA〓 receptor agonist muscimol using behavioural method.

在第二系列的实验中，我们使用行为测痛的方法观察了鞘内注入非竞争性〓受体阻断剂印防已毒素和竞争性〓受体阻断剂荷包牡丹碱，对鞘内注入NE、5-HT和〓受体激动剂muscimol所引起的镇痛作用的影响。

When EGTA (Ca〓 chelator), Verapmil and LaCl〓(Ca〓 channel blockers) were used to treat tomato fruit at green mature and strawberry fruit at white stage with ethylene, they could reverse ethylene-induced increase in ethylene production in tomato and strawberry, PG activity, lycopene content, soluble protein content in cell wall in tomato and degradation in soluble protein in strawberry, which indicated blocking Ca〓 channel in plasma membrane or chelating Ca〓 can decrease intracellular Ca〓, further inhibite ethylene-induced maturation, ripening and senescence of fruit.

用质膜钙通道阻断剂异博定、钙通道Ca〓竞争性抑制剂以及Ca〓专一性螯合剂与乙烯一起处理绿熟期番茄果实和乳白期草莓果实，均可抑制乙烯诱导番茄和草莓的乙烯生成、番茄PG活性的提高、番茄红素含量的增加和细胞壁可溶性蛋白含量的增加以及草莓可溶性蛋白的分解，表明阻断质膜Ca〓通道或螯合胞外Ca〓以减少胞内Ca〓能抑制乙烯对果实的催熟作用，间接证明乙烯对果实成熟衰老的诱导与胞外Ca〓内流引起的胞质Ca〓浓度的增加密切相关，表明乙烯信号转导可能与钙信使有关，调节胞质Ca〓浓度可调节乙烯对果实的催熟作用。

Clinicians should be able to recognize and treat significant toxidromes resulting from acetaminophen; anticholinergic agents including antihistamines and psychoactive drugs; anticoagulants such as warfarin or rat poison; cardiac medications including calcium channel blockers, beta-blockers, and digoxin; muscarinic cholinergic agents including carbamates, some mushrooms, and organophosphates; nicotinic cholinergic agents such as insecticides and nicotine; cyanide; ethylene glycol or methanol from antifreeze or rubbing alcohol; iron-containing products such as deferoxamine; opioids such as morphine, hydrocodone, or methadone; salicylate (aspirin-containing products); sulfonylurea; and sympathomimetic agents such as amphetamines, caffeine, cocaine, or ephedrine.

医师必须可以辨识与治疗乙醯胺酚；抗胆碱剂，如抗组织胺与精神作用药物；抗凝血剂，如warfarin或杀鼠剂；钙离子阻断剂、乙型阻断剂、毛地黄等心脏药物；蕈毒胆碱剂，如氨基甲酸酯盐、某些有毒蘑菇、有机磷农药；菸碱性胆碱剂，如杀虫剂与尼古丁；氰化物；抗冻剂或外用酒精的乙二醇或者甲醇；含铁产品，如 deferoxamine；鸦片类，如吗啡、hydrocodone、美沙冬；水阳酸；硫醯基尿素类降血糖药；拟交感神经药物，如安非他命、咖啡因、古柯碱或麻黄素等造成的明显中毒症候群。

Sulphonyluren tolbutamide (1 mmol/L), a specific KATP channel blocker, added to the bath completely suppressed the channel activity, while diazoxide (1 mmol/L), a KATP channel opener, had no apparent effect.

KATP通道的特异性阻断剂tolbutamide (甲糖宁， 1 mmol/L)可完全阻断通道的活动，而KATP通道开放剂diazoxide (二氮嗪， 1 mmol/L)则不增强通道的活动。

Mutant mice than in wild-type controls, and tetrodotoxin or bicuculline application abolished the difference between the genotypes. Studies on human oligodendroglioma cells revealed that GABA played a protective role on Ca〓 overload induced by OGD or glutamate and phaclofen, GABA〓 receptor antagonist, could significantly block the protection.

结果表明：①电凝大脑中动脉后Ca〓2.3-／-鼠脑梗死率和缺血后运动障碍明显重于Ca〓2.3+／+鼠；②Ca〓2.3-／-鼠海马脑片CA1区缺氧后钙超载明显高于Ca〓2.3+／+鼠；③Na〓通道阻滞剂TTX和GABA〓受体阻断剂bicuculline可显著缩小遗传表型之间的差异；④GABA对缺氧无糖及谷氨酸所致的人胶质细胞瘤细胞Ca〓超载有明显的保护作用，此作用可被GABA〓受体阻断剂phaclofen拮抗。

To determine whether α1 and α2-adrenoceptors are located postsynaptically on renal vascular smooth muscle, a new method was developed as the following: the right renal vascular beds in the pithed rats were perfused with blood drawn from carotid artery at constant rate by a pump.

本实验用颈动脉血恒速满流毁脑脊髓大鼠单侧肾脏的方法，观察了高度选择性α_1受体阻断剂哌唑嗪和α_2受体阻断剂育亨宾与去甲肾上腺素、肾上腺素及电刺激肾交感神经对肾血管平滑肌的相互作用。哌唑嗪明显抑制电刺激引起肾灌流压升高，但尚存留一小部分既不能被增加哌唑嗪的剂量所阻断也不能被育亨宾所阻断。

In order to determine the optimalconcentrations, and treatment durations of two kinds of spindle inhibitors——colchicine and vinblastine, we added different concentrations of them to CZB,respectively. Second, hypotonic treatment were carried out to pick out the besthypotonic fluid, thus we gained the ideal experimental parameter and evaluatedthe metaphases for four grades.

实验中分别添加不同浓度的两种纺锤体阻断剂——秋水仙素和长春花碱进行不同阻断培养时间的实验以确定阻断剂的最佳处理浓度和时间，并以不同低渗液对胚胎进行低渗处理以确定最佳的低渗液种类，从而获得了理想的实验参数，进一步对得到的中期分裂相进行了分级评定。

The study showed that the role of inhibitor of pyridine's ramification was more effective than of pyridine itself, and found that the lycopene could attain 400mg/L when adding 1g/L tobacco dust. The modulator could make different effect on fermentation.

研究了不同阻断剂的阻断效果，结果表明：吡啶衍生物的阻断效果明显高于吡啶，烟草废弃物可阻断番茄红素向β-胡萝卜素的转化，当添加1g/L烟草废弃物时，番茄红素的产量达到400mg/L。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。