阻断

Methods With direct-immunofluorescence flow cytometry,expression of Fas/APO-1 in unsynchronized and synchronized cells of PC-3M cell line derived from non-androgen dependent prostatic carcinoma was detected.

采用直接免疫荧光流式细胞术对前列腺癌细胞系PC-3M未同步化的细胞，及经改良的笑气阻断及TdR双阻断方法同步化的不同细胞周期细胞表面Fas/APO-1表达情况进行检测。

Methods Model of vasoligation and vasostomy in male rat was established, an d then terminal deoxynucleotidyl transferase-mediated dUTP nick labelling techn ique to detect the apoptosis of spermatogenic cells at 4, 8, 12, 16 weeks after v asostomy.

以雄性SD大鼠为研究对象，建立输精管阻断及阻断后复通模型，采用DNA缺口原位标记凋亡细胞方法，观察大鼠生精细胞在输精管复通后4、8、12及16周的凋亡状况。

Our researches include:To establish the rat experimental model of VILI and study the the activation of the receptor of cellular membrane in VILI;To observe the change of transmembrane signal transduction and inflammation cytokine after applying the specific blocking agent of receptors;To observe the change of transmembrane signal transduction and inflammtion cytoking after applying the no specific blocking agent of receptors.

主要内容建立大鼠VILI实验模型，观察各种细胞膜受体（包括整合素受体、生长因子受体、G蛋白偶联受体）及其配体在大潮气量机械通气时的表达变化；应用各种受体的特异性阻断剂，观察对大鼠VILI信号转导通路以及炎症因子表达的影响；应用各种非特异性阻断剂，观察对大鼠VILI信号转导通路以及炎症因子表达的影响。

Raf inhibitors have been developed and some are being evaluated in clinical trials.

一些Raf阻断剂正在临床试验中，因特定Raf基因过表达而发生的恶性肿瘤很可能会对raf蛋白的阻断剂敏感。

A model system simulated the stomach conditions (pH 3.13-3.28, 37℃) was used to study the blocking effect of the Chinese gooseberry juice on the morpholine nitrosation.

在37℃，pH3.13-3.28，吗啉及亚硝酸钠浓度各为2.0mM，经0.5、1.0及2.0小时，其阻断率分别为98.54％，96.43％及97.99％；此结果优于柠檬汁，后者阻断率分别为84.55％，34.79％及37.43％；并优于含同样量的抗坏血酸溶液，其结果分别为97.56％、89.48％及65.62％。

When 2.0 mM NaNO2 and 2.0 mM morpholine reaction systems were incubated at 37℃ for 0.5, 1.0 and 2.0 hours, Chinese gooseberry juice gave 98.54%, 96.43% and 97.99% blocking respectively, the lemon juice gave 84.55%,...

将猕猴桃汁中抗坏血酸经酶氧化后，不同时间阻断率仍分别高达90.24％、88.47％及79.84％；氧化后的柠檬汁阻断率分别为65.04％、10.13％及50.58％。

These effects could be blocked or attenuated by their corresponding antagonists or antibodies.

这些作用能被相应的阻断剂或抗体所阻断或抑制。

Results Both inhibitions of PKC with 6.8 mmolL^(-1) hypericin and PKA with 0.112 mmolL^(-1) KT5720 shifted the dose-response curve of 15-HETE induced pulmonary vasoconstriction to the right, and more powerful inhibition was observed with PKC inhibitor (P.01). Denuding endothelia decreased the response of PA ring to 15-HETE in both normoxic and hypoxic PA rings (P.05, P.01, respectively).

结果 用6.8 mmolL^(-1) hypericin阻断PKC途径可使15-HETE收缩缺氧大鼠肺动脉量效曲线右移(P.01)；用0.112 mmolL^(-1) KT5720阻断PKA途径使15-HETE收缩缺氧大鼠肺动脉量效曲线右移不明显；除去血管内皮细胞可降低对照组和缺氧组肺动脉血管环对15-HETE的反应性。

The team developed a siRNA product that specifically blocks the transcription of the gene that codes for IL-8, thereby blocking production of this protein, and encases it in a liposome delivery system. In mouse studies, this product showed activity against 2 ovarian cancer cell lines, both when used alone and when used in combination with docetaxel. In addition, the mouse studies revealed that the product was decreasing tumor growth through anti-angiogenic mechanisms — the treated tumors showed a lower microvessel density, the researchers report. This product was "highly effective in our preclinical studies and may merit clinical development," they write. However, they also caution that the cell lines used to create the mouse models might not accurately reflect the heterogeneity seen in human tumors.

该团队发展一种siRNA产品，特别阻断IL-8的基因转译密码，因此阻断此一蛋白质之产生，且将它包入一个微脂粒传递系统；在老鼠研究中，不论单独使用或者和docetaxel并用，此产品显示对两种卵巢癌细胞线有活性；此外，老鼠研究发现此产品可透过抗血管新生机转减少肿瘤生长—报告指出，治疗的肿瘤显示较少的微血管密度，此产品在我们的临床前研究中相当有效，值得临床发展；不过，他们也表示，所用的老鼠研究中的细胞线可能无法精准反应人类肿瘤的异质性。

The team developed a siRNA product that specifically blocks the transcription of the gene that codes for IL-8, thereby blocking production of this protein, and encases it in a liposome delivery system. In mouse studies, this product showed activity against 2 ovarian cancer cell lines, both when used alone and when used in combination with docetaxel. In addition, the mouse studies revealed that the product was decreasing tumor growth through anti-angiogenic mechanisms — the treated tumors showed a lower microvessel density, the researchers report. This product was \"highly effective in our preclinical studies and may merit clinical development,\" they write. However, they also caution that the cell lines used to create the mouse models might not accurately reflect the heterogeneity seen in human tumors.

该团队发展一种siRNA產品，特别阻断IL-8的基因转译密码，因此阻断此一蛋白质之產生，且将它包入一个微脂粒传递系统；在老鼠研究中，不论单独使用或者和docetaxel併用，此產品显示对两种卵巢癌细胞线有活性；此外，老鼠研究发现此產品可透过抗血管新生机转减少肿瘤生长—报告指出，治疗的肿瘤显示较少的微血管密度，此產品在我们的临床前研究中相当有效，值得临床发展；不过，他们也表示，所用的老鼠研究中的细胞线可能无法精準反应人类肿瘤的异质性。

Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车，和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特，那个是爱朗。