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阻断

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Intracerebral ventricular injection of M receptor blocker,Atropine(10 μ L 1× 10- 7 mol/L), failed to block the gastric contraction effect of cerebral SP.

侧脑室注射 M 受体阻断剂阿托品 10 μ L(1× 10- 7 mol/L),不能阻断脑内 P物质对胃的收缩效应。

Pretreatment with KATP channel blocker glibenclamide (Gli; 20μmol/L) could partially block the effects of H2S pretreatment (100μmol/L).

应用KATP通道阻断剂格列苯脲( Gli; 20μmol/L ),可部分阻断H2S对乳头状肌细胞的电生理效应。

The sixth, there were no significantly differences between colchicine groupsand vinblastine groups on the metaphases, in the experiment of prepare mouse4-cell embryo stage single blastomere chromosome specimen by using optimumparameters; and there were significantly differences between colchicine groupsand vinblastine groups on the metaphases (P<0.05), in the experiment of preparemouse 8-cell embryo stage single blastomere chromosome specimen by usingoptimum parameters.The end, the preparation quality of mouse 4-and 8-cell embryo stage singleblastomere specimen were 2.5, 2.7, 2.4, 1.9, respectively.

低渗液选用0.45%氯化钠时,低渗效果优于选用0.5%柠檬酸钠和0.35%氯化钾的。6、在利用最佳参数制备小鼠4-细胞期胚胎单卵裂球染色体标本时,经统计分析,两种阻断剂的作用效果差异不显著;而在制备小鼠8-细胞期胚胎单卵裂球染色体时阻断剂选用长春花碱的效果优于秋水仙素的(P<0.05)。7、秋水仙素组和长春花碱组小鼠4、8-细胞胚胎单卵裂球染色体标本制备质量分别为:2.5、2.7、2.4、1.9。

Aim:(1) The purpose of this study is to examine whether protein tyrosine kinase and AMPA receptor in the nucleus tractus solitarius and nucleus ambiguus were involved in the regulation of normoxia and hypoxia respiratory response by microinjection of PTK inhibitor and non-NMDA receptor antagonist;(2) To observe the change of number of phosphotyrosine immunopositive neurons in NTS and NA before and after hypoxia using immunohistochemical methods and whether tyrosine phosphorylation and GluR1 in postsynaptic membrane co-localize in NTS and NA neurons.

目的:(1)观察向家兔脑干孤束核或疑核内微量注射酪氨酸蛋白激酶阻断剂和谷氨酸AMPA受体阻断剂对常氧呼吸和低氧呼吸反应的影响,探讨PTK和AMPA受体在低氧呼吸反应中的作用。(2)观察低氧通气后NTS和NA磷酸化酪氨酸免疫阳性神经元的数量变化;观察磷酸化酪氨酸和AMPA受体亚单位GluR1在突触后膜共存的情况,推测在低氧呼吸反应中AMPA受体和PTK信号转导途径的关系。

In the electrophysiological study in vivo, it was observed that the weak EA could depress the nociceptive responses of spinal dorsal horn neu- rones, which might be blocked by P1—purinergic receptor antagonists.

在横断脊髓的大鼠上用电生理学方法进一步观察到,弱电针也可抑制髓背角广动力型神经元的伤害性反应,弱电针的这种效应也可被腺苷受体阻断剂所阻断,说明嘌呤类在脊髓水平参与弱电针镇痛。

By pretreatment with ruthenium red (RR, 100 1 μmol/L), an antagonist of vanilloid receptor subtype 1 (VR1), the above effects of CAP on carotid baroreflex were abolished.

2用香草酸受体亚型(vanilloid receptor subtype 1, VR1)阻断剂钌红(ruthenium red, 100 μmol/L)预处理后,CAP的上述反射效应即被阻断

This inhibitory effect was increased by 4ɑ-PDD, a selective TRPV4 receptor agonist, and was reversed by ruthenium red, a nonselective TRPV4 receptor antagonist, suggesting that the inhibition is mediated via TRPV4 receptor.

4低渗透压对IATP的抑制作用可被TRPV4(transient receptor potential vanilloid 4)受体激动剂4ɑ-PDD(4ɑ-phorbol 12,13-didecanoate)增强,并可被TRPV4受体非特异性阻断剂钌红(ruthemium red, RR)阻断

The results obtained are as follows.(1) Following microinjection of capsaicin (10μmol/L, 50nl) into the AP, MAP, HR and RSNA were significantly increased from l2.34±0.53 kPa,328.52±7.54 bpm and 100±0% to 15.17±0.25kPa (P.001), 354.81±8.54bpm (P.001) and 156.95±7.57%(P.001), respectively.(2) Ruthenium red (RR, 100mmol/L, 0.2ml, iv), a capsaicin receptor antagonist, significantly inhibited these effects of capsaicin.(3) Pretreatment with a NMDA receptor antagonist MK-801 (500μg/kg, 0.2ml, iv) also reduced these effects of capsaicin.

实验结果如下:(1)最后区内注射辣椒素可引起MAP、HR和RSNA明显增加,分别由12.34±0.53kPa、328.52±7.54bpm和100±0%增至15.17±0.25kPa(P<0.001)、354.81±8.54bpm(P.001)和156.95±7.57%(P.001);(2)静脉注射辣椒素受体阻断剂钌红(100mmol/L, 0.2ml)后,辣椒素的上述效应可被明显抑制;(3)预先应用NMDA受体阻断剂MK-801(500μg/kg, 0.2ml, iv)也明显抑制辣椒素的兴奋效应。

On the basis of analyzing the mechanism of the hydraulic pulse, the rock-breaking mechanism of themechanical cut-out hydraulic pulse is discussed by using transient flow theory, the working principle and its structural characters of SLPMC mechanical cut-out hydraulic pulse tool are introduced.

在分析水力脉冲产生机理的基础上,探讨了基于瞬变流理论的机械阻断式水力脉冲破岩机理,介绍了SLPMC机械阻断式水力脉冲工具的工作原理及结构特点,简单叙述了该工具在胜利油田进行的2口井的现场试验情况。

In a 12-week study of 40 obese people, those using the starch neutraliser lost an average of 3.5kg (7lb 11oz) each, compared with an average weight loss of 1.2kg (2lb 10oz) by those in the control group.

2在为期12周的研究中, 40个肥胖的人,那些服用淀粉阻断剂的一组平均每人减少三点五公斤(七磅11盎司),而没有服用淀粉阻断剂的控制组平均每人失重一点二公斤。

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