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Methods The clinical and histopathologic symptoms of two patients with sarcomatoid carcinoma of the bladder were macrohematuria and vesical irritability. Cystoscopy showed the carcinoma was solid tumor with necrotic tissue on the surface. Sarcomatoid carcinoma was mainly composed of transitional epithelial cancer cells and malignant mesenchymal cells (spindle cells and polymorphic cells), with a transitional region of interlacement of these cells. Immunohistochemical testing showed the cells were positive for cytokeratin, c arcinoembryonic antigen and smooth muscle actin.

分析2例膀胱肉瘤样癌患者的临床资料并结合文献进行讨论。2例患者均有肉眼血尿或伴有膀胱刺激症,膀胱镜检查为实体瘤,表面有坏死组织;病理表现,肿瘤主要由移行上皮癌细胞和恶性间叶细胞组成,之间可见移行过渡;免疫组化CK、CEA、SMA。

A total of 150 mesenchymal neoplasms of the GI tract, abdominal cavity, and retroperitoneum were retrieved from consult and surgical pathology archives, including 54 GISTs (8 KIT-negative; 13 desmin-positive), 17 GI leiomyosarcomas, 11 GI mural leiomyomas, 13 leiomyomas of the muscularis mucosae, 12 gastric schwannomas, 15 inflammatory myofibroblastic tumors, 9 cases of mesenteric desmoid fibromatosis, 10 dedifferentiated liposarcomas, and 9 malignant peripheral nerve sheath tumors.

我们从会诊病例及活检病例中找出150例间叶性肿瘤(来自胃肠道、腹腔和后腹膜),其中包括54例GISTs(8例KIT阴性、13例desmin阳性)、17例GI道平滑肌肉瘤、11例GI道肌壁间平滑肌瘤、13例GI道粘膜肌层平滑肌瘤、12例胃的神经鞘瘤、15例炎性肌纤维母细胞瘤、9例肠系膜韧带样纤维瘤、10例去分化型脂肪肉瘤和9例恶性外周神经鞘膜瘤。

Results Histologically, AT/RT was characterized by the presence of rhabdoid cells associated with various degrees of primitive neuroectodermal, epithelial or mesenchymal differentiation.

结果 非典型畸胎样/横纹肌样瘤具有特征性的横纹肌样细胞,伴有不同程度的原始神经外胚叶、上皮和间质分化。

For tumors which have been well sampled and exhibit (1) a microcystic pattern and regions with lobulated cellular masses with intervening, sometimes hyalinized fibrous stroma,(2) an absence of morphologic features enabling any other specific diagnosis in the sex cord-stromal category,(3) an absence of epithelial elements, and (4) an absence of teratomatous or other germ cell elements, we propose the designation microcystic stromal tumor.

我们很好地抽样调查了4例肿瘤,显示:(1)微囊样式和有时插入玻璃样变的纤维间质中的分叶状细胞团区,(2)能造成在性索间质这个大类中其他具体诊断的形态特征缺失,(3)上皮成分缺失,(4)畸胎或其他胚芽细胞成分缺失,我们提议定其名为微囊性间质瘤。

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