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Objective To study the relation b etween cancer cells in portal vein blood and liver metastasis of colorectal carc inoma.

目的 探讨门静脉血癌细胞与大肠癌肝转移的关系。

Aim To investigate the pharmacokinetics of rabeprazole after intravenous, intraportal and intraduodenal administration at various doses and to clarify the impact of hepatic and intestinal first-pass effects to bioavailability of rabbits.

目的 研究雷贝拉唑在大白兔体内经十二指肠、门静脉与外周静脉等不同方式及不同剂量给药时的药代动力学,并探讨肠道、肝脏首过效应分别对其生物利用度的影响。

A modification of a twostep perfusion protocol and isopycnic centrifugation were used to isolate oval cells from livers.

门静脉灌注消化法和等密度离心法分离卵圆细胞,并在体外进行长期培养。

A modification of two-step perfusion protocol and isopycnic centrifugation were used to isolate oval cells from liver. Primary oval cells were cutured in LE medium in vitro.

门静脉灌注消化法和等密度离心法分离卵圆细胞,并在体外进行原代培养。

Results The drug concentration in the abdoninal cavity was highst,the janitrix was secondary,the abdominal aorta and peripheral venous was the lowest .

结果:腹腔给药后药物在腹腔液中的浓度最高,其峰值浓度是外周静脉血中药物浓度的266.7倍,门静脉其次,约11.3倍,腹主动脉,外周静脉血浓度相仿,为最低。

The drug concentration in the janitrix and the abdoninal cavity is higher than that in the abdoninal aorta and peripheral venous after the treatment.The tissue of liver is about the same to kidney .The durg concentration in the janitrix and tissues is high and invariant for a long time. TACE and sequential chemotherapy inhibit the development of the cancer synergily and the latter cannot induce the toxic reaction.

化疗药物腹腔给药后门静脉血中,腹腔液中药物浓度显著高于腹主动脉,外周静脉血;腹腔给药后,肝组织中药物浓度高于肾组织;药物在门静脉,组织中存在较高的药物浓度,递减缓慢,浓度恒定,维持时间长;肝动脉化疗栓塞术有效地控制了肿瘤的大小,序贯化疗亦有效地抑制了肿瘤的发展和转移,两者间作用相互协同;序贯化疗不增加肿瘤病人的化疗毒副反应。

Patients all diagnose: Wo of Chan of axil the Kingdom of Wei not liver function of lienal big; breaks; of high pressure of? portal vein take the place of the enteron on countervail period; bleeds.

其中男36例,女24例,平均(63·20±6·76)岁。60例患者均诊断:乙肝后肝硬化;门静脉高压;脾大;肝功能失代偿期;上消化道出血。

Results Among 6 cases with PCTPV, 4 cases revealed occlusion of the main branch of portal vein at the hepatic hilum, 2 cases revealed occlusion of the common portal vein, and a masslike network of tortuous veins around the hepatic hilum and many small irregular veins radiating from the network to the liver were demonstrated.

结果:6例中4例清楚显示门脉主要分支近肝门处阻塞,2例门静脉主干阻塞,代之以肿块样纡曲血管并在其周围形成向肝性放射状侧支血管影像,以及离肝性侧支循环静脉。6例CT血管成像均能对与分流或断流手术有关的血管解剖提供准确信息。

Asymmetric dimethylarginine and monomethyl arginine are endogenously produced amino acids that inhibit all three isoforms of nitric oxide synthase.

点评:内皮一氧化氮以及一氧化氮合酶是目前门静脉高压症以及相关并发症的发病机制的研究热点之一,本文研究了抑制NOS的内源性氨基酸类化合物的清除酶—-二甲基精氨酸–二甲氨基水解酶,进一步的深入探究了这一发病机制,为今后治疗作用位点的选择、药物研发以及相关实验研究提供了一定的理论依据,个人认为该实验意义较大。

Our aim in this observational, prospective, noncontrolled studywas to detect, in 29 patients who underwent abdominal aorticaneurysm surgery, correlations between the incidence ofpostoperative organ failure and intraoperative changes in arterialand portal blood lactate; changes in intramucosal sigmoid pH; differences between sigmoid PCO2 and arterial PCO2 ( CO2);and hemoglobin.

我们在这个观察性、前瞻性、非对照研究中的目的是探求29例腹主动脉瘤手术后患者器官衰竭发生率与术中动脉和门静脉乳酸变化、乙状结肠粘膜内 pH变化、乙状结肠粘膜 PCO2和动脉 PCO2差值(ΔCO2)以及血红蛋白的关系。

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