门冬酰

High expression of cellular asparagine synthetase is a causative factor for the resistance of leukemic cell to Lasparaginase therapy.

细胞内门冬酰胺合成酶（asparagines synthetase， AS）的表达水平与白血病细胞对左旋门冬酰胺酶耐药有关。

OBJECTIVE: To study the cellular activity of asparagine synthetase in different types of childhood acute lymphoblastic leukemia.

目的：不同类型急性淋巴细胞性白血病对左旋门冬酰胺酶敏感度不完全相同，由于LAsp活性水平与细胞内门冬酰胺合成酶活性负相关，因此研究不同类型ALL患儿白血病细胞内门冬酰胺合成酶活性水平分布情况，有助于临床治疗中合理使用LAsp。

This study was purposed to investigate the possible side effects of L-asparaginase in the treatment of patients with acute lymphoblastic leukemia and to explore the corelation of these side effects at different therapeutic stages by means of retrospective analysis, so as to reduce the incidence of side effects and improve the safety of chemotherapy and the long-term survival of patients.

本研究采用回顾性方法分析左旋门冬酰胺酶在儿童急性淋巴细胞性白血病治疗过程中可能发生的副作用，以探索L-ASP副作用的发生与患儿所处治疗阶段的关系，以便采用有效的监测手段减少副作用的发生，提高化疗安全性及患儿的长期存活率。

ABSTRACT］ Objective To discuss the effect of Lasparaginase on coagulation function and its management in children with acute lymphoblastic leukemia.

目的 探讨左旋门冬酰胺酶对急性淋巴细胞性白血病病儿凝血功能的影响及处理对策。

Our study focused upon the precentral gyrus to determine whether any signal changes could be detected in ALS patients; and to determine whether riluzole can reverse corticomotoneuron damage in patients with ALS.

质子磁共振波谱是一种可以无创性定量测定在体脑内生化物质的方法，在对ALS病人双侧大脑中央前回进行质子波谱分析后显示：（1）NAA/Cr （N-乙酰门冬氨酸/肌酸）比值在ALS病人上显著降低，P.01。

I am accused of being overreligious," she said in her quiet, frank manner,"but that does not prevent me thinking the children very cruel who obstinately commit such suicide.""

客人们在卡罗利娜·埃凯家里，举止就文雅一些，因为卡罗利娜的母亲治家很严厉。

Designed by French fashion house Herm è s, this elegant uniform was manufactured in our home, Hong Kong, and was the first without a hat.

由著名品牌 Herm è s 设计，这件高贵的制服是香港本土制造，是我们第一套不配帽子的制服。