镇痛作用

Objective:To study the protective effects of Xuedan on the experimental gastric ulcer and the effects of anti inflammatory, analgesic and bacteriostasis.

中文摘要：目的：研究雪胆提取物对实验性胃溃疡的保护作用及抗炎、镇痛、抑菌等作用。

Methods: Adopting pig bile culture medium, the inhibiting or killing effects on pig bladder worm in vitro were observed;by using the methods of xylene-induced ear inflammation in mice and granuloma swelling induced by cotton ball in rats, the effects of anti-inflammation were observed;by using the methods of body twisting and hot-plate in mice, the effects of analgesia were observed. Through the mice auricle microcycle, the rats thrombus law in vitro and bleeding time, clotting time determination to the mice, the function of invigorating the blood were observed;adopting the penicillin abdominal cavity injection method, the mice epilepsy model were prepared, and epilepsy mice brain organization MDA content and SOD, ATPase vigor be measured by using chemical colorimetry.

利用猪胆汁培养基观察该方在体外对猪囊尾蚴的抑制或杀灭作用；采用二甲苯所致小鼠耳肿胀法、大鼠棉球肉芽肿法以观察该方的抗炎作用；采用热板法和化学刺激扭体法观察该方的镇痛效果；通过小鼠耳廓微循环法、大鼠体外血栓法和对小鼠出、凝血时的测定观察该方的活血作用；采用青霉素腹腔注射法制备小鼠癫痫模型，并利用化学比色法检测癫痫小鼠脑组织中MDA的含量及SOD、ATPase的活力。

Objective: To compare the effects of anti-inflammatory and analgesia when the total alkaloid of monkshood processed by a new method is thirteen times higher than that of its small pieces.

目的：比较新法加工附子在总生物碱高于附片13倍时，其抗炎、镇痛的效果是否有差异。方法：通过小鼠热板法、扭体法、小鼠耳廓肿胀法和大鼠足趾肿胀法进行镇痛和抗炎作用比较。

It is well known that presynaptic inhibition plays an important role in the pain modulation, such a...

现已证明：它在针刺镇痛，电刺激镇痛和药物镇痛等痛觉调制过程中发挥重要作用。

ConclusionQiXingZhenTongGao has a effect of abirritation and anti-inflammation.

七星镇痛膏对疼痛和炎症具有较显著的镇痛及抗炎作用。

E. , ACTH antagonizes the analgesia mediated byμand δ opioid receptors, but notκreceptor;(2) The antagonizing effect of ACTH on opioid analgesia is proposed to be mediated by ACTH receptors, although the latter has not been characterized;(3) A contradictory interaction on intracellular cAMP content may constitute one of the postreceptor mechanisms underlying ACTH antagonism of opioid analgesia;(4) Another proposed mechanism of the anti-opioid effect of ACTH is that ACTH can modulate opioid-induced suppression of calcium influx;(5) ACTH has been shown to induce Fos protein expression in selected areas of the rat brain including the nuclei involved in pain regulation as well as the ependyma of the third ventricle and the aqueduct.

根据以上实验结果，本论文首次提出以下论点：（1）ACTH在脊髓水平对抗阿片镇痛具有受体选择性，即ACTH可对抗μ受体和δ受体介导的镇痛，不对抗κ受体所介导的镇痛；（2）由于ACTH与阿片μ受体的肽类配体的结合位点仅有很低的亲和力，与μ受体的非肽类配体的结合位点以及δ受体无亲和力，推测ACTH是通过中枢内的ACTH受体介导发挥抗阿片效应的；（3）ACTH抗阿片作用的受体后作用机制之一是在cAMP信使通路水平与阿片发生相互作用；（4）ACTH抗阿片作用的另一受体后机制是在〓水平影响阿片的效应；（5）通过Fos蛋白的诱导揭示：ACTH可以作用于脑内多个核团，其中包括许多与痛觉调制有关的核团，推测ACTH可能通过激活这些核团的神经元而发挥其中枢效应。

The better the efficacy of their combination in analgesia, the fewer the side effects. As reducing each dose without decreasing spinal blood flow, it is nonpoisonous to nerval system and safe to use for postoperative analgesia.

研究表明两者联用可减少各自的剂量而使副作用更少，镇痛效应更强且不减少脊髓血流，对神经系统无毒性作用，能安全地用于术后镇痛。

By push-pull perfusion technique and radioenzymatic assay, it was found that after 10 min of acupuncture, pain threshold increased significantly, while the content of NA in the perfusate from the preoptic area was markedly decreased.

b。用推挽灌流技术结合放射酶学法，观察针刺镇痛时视前区NA释放的变化，从递质释放的角度，探讨视前区的NA在针刺镇痛中的作用。结果观察到针刺10min后，动物痛阈明显升高，此时视前区灌流液中的NA含量显著减少。

rutaecarpine pharmacological effects and its related mechanism: rutaecarpine the heart positive inotropic, positive changes in the role and the heart protective effect, which with its promotion of calcitonin gene-related peptide release; rutaecarpine alkali have vasodilative and hypotensive effect, its mechanism mainly related to endothelial cells Ca2 +-NO-cGMP pathways and calcitonin gene-related peptide release; rutaecarpine to relax the anal sphincter, gastrointestinal motility inhibition of stress ulcer and ulcerative colitis have therapeutic effect; rutaecarpine on cerebral ischemia-reperfusion injury has a protective effect, which instead of increasing the concentration of calcitonin gene-related peptide-related; rutaecarpine inhibits platelet aggregation and arterial thrombosis; In addition, rutaecarpine Alkali also anti-inflammatory and analgesic, anti-tumor and other pharmacological effects.

综述了吴茱萸次碱的药理作用及其相关机制：吴茱萸次碱对心脏有正性肌力、正性变时作用和心脏保护作用，这与其促进降钙素基因相关肽释放有关；吴茱萸次碱有扩血管和降压作用，其机制主要涉及内皮细胞Ca2+-NO-cGMP途径和降钙素基因相关肽的释放；吴茱萸次碱能松弛肛门内括约肌，抑制胃肠运动，对应激性溃疡和溃疡性结肠炎也有治疗作用；吴茱萸次碱对脑缺血再灌注损伤有保护作用，这与其增加降钙素基因相关肽浓度有关；吴茱萸次碱能抑制血小板聚集和动脉血栓形成；此外，吴茱萸次碱还有抗炎镇痛、抗肿瘤等药理作用。

PAP suppresses pain by functioning as an ecto-5′-nucleotidase.

PAP的镇痛作用被认为同ecto-5'-nucleotidase功能一样。

Lugalbanda was a god and shepherd king of Uruk where he was worshipped for over a thousand years.

Lugalbanda 是神和被崇拜了一千年多 Uruk古埃及喜克索王朝国王。

I am coming just now,' and went on perfuming himself with Hunut, then he came and sat.

我来只是现在，'歼灭战perfuming自己与胡努特，那麼，他来到和SAT 。