镇痛作用

RESULTS Asarum and A V compound has remarkable analgestic effect of pain in mice induced by acetic acid and hot plate.

结果 细辛及A V复方制剂对醋酸致小鼠腹痛、热板法致小鼠足痛均有明显的镇痛作用并能抑制蟾蜍坐骨神经动作电位的传导。verapamil有弱的镇痛作用，无坐骨神经动作电位阻滞作用。

In order to understand the mechanism of anti-inflammatory effect of PA and carvacrol, the superoxide dismutase, glutahoine reductase, glutahoine peroxidase activities in liver and malondialdehyde , cyclooxygenase 2 (COX-2), tumor necrosis factor-α levels were eveluated. Also observed inducible nitric oxide synthase and cyclooxygenase-2 (COX-2) expression and the pathological histology in λ-carrageenan induced paw edema in mice.

本研究首先以醋酸扭体试验评估左手香水抽提物及其活性成分香芹酚是否具有镇痛效果，以福马林舔足试验辨别其镇痛作用是在周边或是中枢，再以λ-角叉菜胶诱导小鼠足跖肿胀试验探讨其抗发炎作用，并分析其肝脏组织中的超氧歧化酶、麸胱甘肽还原酶、麸胱甘肽过氧化酶活性、发炎足跖组织中的脂质过氧化指标产物丙二醛、肿瘤坏死因子-α及环氧化酶-2之含量变化，观察诱导型一氧化氮合成酶及环氧化酶-2之蛋白质表现量，并将肿胀足跖做病理切片观察之，以探讨左手香水抽提物及香芹酚之抗发炎机转。

①postoperative pain after hemorrhoidectomy can be safely and effectively controlled by Acuepoint inject of lappaconitine hydrobromide ②Using the Ashi-points-injection of lappaconitine hydrobromide after hemorrhoidectomy can reduce the pain for a longtime ③Combined with Yaoshu-point-injection can enhance the anaesthetic effect at the day of surgery④The edema at anal margin can be reduced by using of Ashi-points-injection of lappaconitine hydrobromide

①穴位注射氢溴酸高乌甲素对痔术后镇痛是安全而有效的；②术毕时使用氢溴酸高乌甲素阿是穴注射具有术后长效镇痛作用；③联合使用氢溴酸高乌甲素腰俞穴注射可增强手术当天的镇痛效果；④氢溴酸高乌甲素穴位注射具有防止痔术后肛缘水肿的作用。

ResultsThe inhibitory ratio of retortion of mice induced by acetic acid was 64.24% and 24.24% respectively after QiXingZhenTongGao being administered at the pain threshold of mice.

方法采用醋酸建立小鼠疼痛扭体模型及小鼠热板法，观察七星镇痛膏的镇痛作用；采用二甲苯所致小鼠耳廓肿胀和右旋糖酐所致大鼠足跖肿胀形成模型，观察七星镇痛膏的抗炎作用。

Thus, the analgesic effect of morphine injected into PAG was significantly attenuated by β-EP AS injected into the nucleus accumbens, and vice versa. This antagonistic effect was totally abolished by lesioning of the ARH. Moreover the analgesic effect of morphine injected into nucleus accumbens could be blocked byβ-EP AS administered te amygdala or habenula.

在PAG内注射吗啡产生的镇痛作用可被伏核内注射β-EP抗体所削弱，损毁家兔的ARH后这一对抗效应基本消失；在伏核内注射吗啡产生的镇痛作用可被PAG内注射β-EP抗体所对抗，损毁ARH后上述对抗效应基本消失；伏核内注射吗啡产生的镇痛作用亦可被杏仁核内或缰核内注射β-EP抗体所阻断。

Clonidine (20ug/bilateral), an alpha agonist, produced similar effect as NA; while phentolamine (10ug/unilateral), an alpha antagonist, brought about an enhancement of AA, This phenomenon was observed in the acupuncture effective group, but not in the acupuncture uneffective one. However, propranolol (10ug/unilateral), a beta antagonist, had no effect on AA in these two groups.

结果表明，微量注射NA（0.5μg/单侧）能部分翻转针刺镇痛作用；α受体激动剂可乐定（20μg/双侧）也有同样作用；而α受体拮抗剂酚妥拉明（10μg/单侧）可以显著加强针刺有效组家兔的针刺镇痛作用，但对针刺无效组的痛阈无明显影响；β受体拮抗剂心得安（10μg/单侧）则对针刺有效或无效组的痛阈均无显著作用。

The mechanism may be related with the action of increasing β-EP content in hypothalamus and blood plasma and dilating peripheral blood vessel.

脉痛宁有明显的镇痛作用，其镇痛机制可能是通过提高大鼠中枢和周围血浆中β-EP含量和通过扩张周围血管发挥镇痛作用。

Objective To establish a HPLC method for the determination of aceclofenac in human plasma.Methods Acidified samples of plasma (500μL) were extracted with 4 mL of ethyl acetate. The organic phase was evaporated to dryness by nitrogen at 40℃ water bath. The residue was redissolved in mobile phase and then was determined.

醋氯芬酸是一种具有镇痛作用的非甾体类抗炎药物[1]，化学名为[邻-(2，6-二氯苯基)氨基]苯乙酰乙酸，l992年首先于西班牙上市，具有明显广泛的抗炎作用和强力的解热镇痛作用，其生物半衰期较双氯芬酸长，胃肠耐受性较双氯芬酸好，抗炎活性优于萘普生和保泰松[2]。

Rabbits were equipped with intracerebral cannulae directing to two of the four nuclei.

我们在研究吗啡的中枢作用部位时发现，注射微量吗啡到家兔或大鼠的PAG、伏核、杏仁核或缰核内，可产生明显的镇痛作用；而将阿片受体阻断剂纳洛酮注入上述任一核团内，则能大部取消静脉注射吗啡产生的镇痛或电针引起的镇痛。

Results: 1st, through the method of the mouse ear swelling as well as chemical stimulations analgesia experimental method and hot plates analgesia experimental technique the hotplate method experiment, had proven the treatment law of removing blood stasis and dredging collateral of the acupuncture and moxibustion to have the obvious effect of anti-inflammation and analgesic p

1、针灸化瘀通络法抗炎镇痛效果明显，抗炎作用可能主要与抑制细胞因子释放有关，而镇痛作用可能主要与抑制外周K~+、NE、DA和5-HT释放有关。2、针灸化瘀通络法有抑制XOD的活性，减少尿酸生成和促进尿酸排泄的作用。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。