锥虫病

With a current portfolio of 22 projects, DNDi aims to develop new, improved and field-relevant drugs for neglected diseases, such as malaria, leishmaniasis, Human African trypanosomiasis, and chagas disease.

组织的目标旨在研发创新、改良及适合在资源贫匮地区使用的药物，治疗被忽略疾病，包括疟疾、利什曼病、非洲锥虫病以及南美锥虫病。

Serious attention to the trypanosomes of mammals was drawn by the work of Timothy Lewis on the parasite of Indian rats, the importance of which was realized after Griffith Evans (1880) discovered the pathogenic trypanosome in horses and camels in India Trypanosoma evansi

Timothy Lewis对印度老鼠的寄生虫的研究引起了人们对于哺乳动物锥虫病的严重关注。Griffith Evans (1880)在印度发现马和骆驼身上的致病性锥虫之后，人们才认识到了哺乳动物锥虫病的重要性。

BACKGROUND: Human African trypanosomiasis (HAT; sleeping sickness) caused by Trypanosoma brucei gambiense is a fatal disease.

背景：由布氏冈比亚锥虫引起的非洲人类锥虫病是一种致命的疾病。

Protozoa are responsible for diseases such as malaria, amebic dysentery, giardia, leishmaniasis, and trypanosomiasis.

原生动物是类似疟疾、阿米巴痢疾、贾第虫症、黑热病和锥虫病的罪魁祸首。

Protozoa are responsible for diseases such as malaria, amebic dysentery, giardia, leshmaniasis, and trypanosomiasis.

原生动物是类似疟疾，阿米巴痢疾，贾第虫症，黑热病和锥虫病的罪魁祸首。

Six diseases (filariasis, leishmaniasis, leprosy, malaria, schistosomiasis and trypanosomiasis) are included in the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases

丝虫病、利什曼病、麻风病、血吸虫病、疟疾、锥虫病等六种病包括在联合国计划开发署；世界银行；WHO的热带病研究与培训特别规划中

The book introduces the animal models representing natural infections ranging from uni- to multicellular and from endo- to ectoparasites in fish, chickens and mammals, including structural and physiological aspects of cell death; Role of apoptosis in non-mammalian host-parasite relationships; thionine-positive cells in relation to parasites; animal models for the study of innate immunity; interaction between sea lice and their hosts; pathophysiology of salmonids cryptobiosis and glossina-transmitted mammalian trypanosomiasis in livestock; avian coccidiosis; interactions betweem fish hosts and monogeneans.

该书介绍了鱼类，小鸡和哺乳动物从单细胞到多细胞和从内寄生虫到外寄生虫的天然传染的动物模型，包括细胞死亡的结构和生理学方向；非哺乳动物宿主和寄生虫关系中细胞凋亡的作用；硫堇阳性细胞与寄生虫的关系；用于先天免疫研究的动物模型；海虱与其宿主的相互作用；鲑鱼隐生想象的生理病理学和家畜中舌蝇传播的哺乳动物锥虫病；鸟类球虫病；鱼类宿主与单殖亚纲动物的相互作用。

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial.

硝呋莫司-依氟鸟氨酸为第二阶段的非洲布氏冈比亚锥虫锥虫病的联合治疗：多中心、随机、III期、非劣效试验。

Any of various parasitic flagellate protozoans of the genus Trypanosoma, transmitted to the vertebrate bloodstream, lymph, and spinal fluid by certain insects and often causing diseases such as sleeping sickness and nagana.

锥体虫锥体虫属中的一种寄生性带鞭毛原生动物；被某些昆虫带入脊椎动物的血液淋巴液和脊髓，可导致嗜眠性脑炎及非洲锥虫病等疾病

We found that Rhodnius prolixus, a triatomine bug feeding on the blood of various tetrapods and vector of Chagas' disease in humans, carries in its genome four distinct transposon families that also invaded the genomes of a diverse, but overlapping, set of tetrapods.

具体来说，长红锥蝽（一种以四足动物血液为食、是人类锥虫病传播媒介的虫子）的基因组中有四个截然不同的转位子家族，它们入侵包括负鼠和松鼠猴在内的一系列不同四足动物的基因组。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。