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The binding of BmK abT to rat brain synaptosomes could be partially inhibited by increasing the membrane potential, but not by BmK AS, BmK IT2 and BmK I. Binding was not modulated by veratridine.

对于哺乳动物脑型钠通道,BmK abT 的结合位点可能不同于BmK AS、BmK IT2 和BmK I 的结合位点,但与经典的α-型毒素结合位点较为接近;对于昆虫钠通道,BmK abT 的结合位点至少部分与抑制型抗昆虫毒素BmK IT2 的结合位点相互重叠。

Recently, a nearly E-W-striking, over 10 km long albitite zone has been recognized for the first time in the Lower Silurian Meiziya Formation in a Lower Paleozoic lead-zinc ore deposit concentration area of the Xunyang basin, South Qinling. It shows a conformable contact and gradational relationships with the country rocks and has thick-bedded and massive, banded, brecciated structures and fine and very fine equigranular and intraclastic textures. It is chemically characterized by enrichment in SiO2, Al2O3 and Na2O and is rich in the trace elements Fe and Mn and poor in the trace elements Co, Ni and Cu. Its ∑REE, LREE and HREE are lower than those of the country rocks and exhibit pronounced Eu depletion.

最近,在南秦岭旬阳盆地下古生界铅锌矿集区内的志留系梅子垭组地层中首次识别出一条近东西方向延伸长达10余千米的钠长石沉积岩带,与地层整合产出,渐变过渡,厚层块状,条带状,角砾状构造,均粒微-细晶结构,内碎屑结构;其化学成分以富含SiO2,Al2O3及Na2O为特征,富Fe,Mn,贫Co,Ni,Cu等微量元素;该钠长石岩的∑REE,LREE,HREE均较围岩偏低,具明显Eu亏损的特征。

Given the current complexity of industrial recovery of 3'-methyl-2'-butenyl 3, 3-dimethyl-pentenoate and the decomposition problems with 2-methyl-1-butene, research was conducted on a process for direct recycling of MBDP involving an ester exchange reaction of MBDP with either methanol, trimethyl orthoacetate, or solutions of methanol and trimethyl orthoacetate.

针对目前工业上回收3,3-二甲基-4-戊烯酸-3'-甲基-2'-丁烯酯工艺复杂、异戊烯大量分解问题,研究了MBDP直接返回循环使用工艺,MBDP与甲醇、原乙酸三甲酯或与甲醇原乙酸三甲酯混合溶液进行酯交换反应的回收新工艺,比较了四异丙基钛酸酯、甲醇钠、氢氧化钾用作酯交换催化剂的效果,筛选出回收MBDP&一锅煮&最佳工艺:按照n:n:n:n=1.0:9.8:9.2:0.05物质的量比投料,74℃~78℃反应21h,MBDP转化为贲亭酸甲酯和异戊烯醇,单程转化率87.7%,用85%的磷酸中和甲醇钠,蒸出甲醇,直接用于合成贲亭酸甲酯。

The main steps include as follows: CO2 is led into the mother liquor of sodium meta-aluminate to carry out carbon content decomposing; the primary separation between the aluminum and the gallium is realized by primary carbonatation to filter out sodium hydroxide; secondary carbonatation is carried out on the filtrate to obtain the deposit of the complex salt of gallium and aluminum; a sodium carbonate crystal is obtained after the filtered filtrate is condensed and vaporized; the deposit of the complex salt of gallium and aluminum is dissolved in the mother liquor of sodium meta-aluminate; the processes are repeated until the proportion of gallium and aluminum in the complex salt of gallium and aluminum is larger than 1/340; then the complex salt of gallium and aluminum is added into the NaOH liquor and electrolyzed, thus obtaining the metal gallium with a purity larger than 99.9 percent which reaches the level of 3; simultaneously, the byproducts of the aluminum hydroxide and the sodium carbonate during the process of carbonatation by steps are obtained.

主要步骤包括:向铝酸钠母液中通入CO 2 进行碳分分解,一次碳酸化实现铝镓的初次分离;过滤出氢氧化钠,滤液进行二次碳酸化获得镓铝复盐沉淀,过滤后滤液经浓缩蒸发获得碳酸钠晶体,铝镓复盐沉淀溶解在偏铝酸钠母液中,重复上述过程直至铝镓复盐中的镓铝比例大于1/340,将其加入到NaOH溶液中,电解可获得纯度>99.9%的金属镓,达到3N级水平同时在分步碳酸化的过程中获得氢氧化铝和碳酸钠副产品。

By comparative analysis of applicability, we concluded that the microcapsule from sodium alginate used in carbonless copy paper had the same advantages as domestic and foreign抯 in the characteristic of use, stableness and the speed of color development and so on.

证明了以海藻酸钠为壁材单凝聚法制备的无碳复写纸用微囊具有较高的包埋率、不渗透性、稳定性及一定强度;通过应用性的对比分析,认为以海藻酸钠为壁材自制的无碳复写纸用微囊在使用性能、稳定性、显色速度等方面均可达到国内外无碳复写纸的水平。

According to petrographic facies test, gravel sample mainly consists of quartz, albite, dolomite, and minor biotite; and sand sample is mainly made up of quartz and albite. As an important ASR active mineral, chalcedonite exists in fractures of dolomite and in matrix of cherty limestone. In rapid mortar bar test, expansion of sand, small gravel and middle gravel at 14 day are less than 0.1%, but keep increasing in long term.

岩相法检测显示卵石样品主要由石英、钠长石及白云石和少量云母类矿物组成,砂样品主要由石英、钠长石等矿物组成,重要的碱活性物质玉髓主要出现在白云岩裂隙和硅质灰岩的基质中;&砂浆棒快速法&检测结果显示砂、小石、中石样品14天的膨胀率均不超过0.1%,为非碱-硅酸反应活性骨料,但卵石样品仍具有一定的碱活性,且后期膨胀率一直持续增长。

The chemical structure of the product was characterized by means of the melting point and IR. The results show that tetraethylammonium bromide which was used as a phase transfer catalyst in this reaction had optimization effect on the interfacial diffusive reaction of BTC and PNP. Higher concentration of sodium hydroxide, lower temperature and a higher dosage of BTC produced a small amount of 4-nitrophenyl chloroformate, while lower concentration of sodium hydroxide and a lower dosage of BTC made reaction incomplete, which affected the yield.

结果表明,在碳酸二(4-硝基苯基)酯合成中使用的相转移催化剂四乙基溴化铵对受界面扩散控制的BTC气与对硝基酚钠反应有良好的相转移催化效果;氢氧化钠质量分数较低时,酚钠盐向溶有BTC的油相扩散速度较小,较高时会产生氯甲酸对硝基苯酯;温度较低、BTC量较高时,会产生少量氯甲酸对硝基苯酯,BTC用量较低会使反应不完全,这些都影响着收率。

Methods The compound preparation was administered intragastrically in mice, whose spontaneous activity was observed along with their tolerance of the preparation after long-term administration. The hypnotic effect of the compound was assessed by investigating the changes in the pentobarbital sodium-induced sleeping. The compound was tested for its antiseizure effect in mice with pentetrazole-induced clonic and tonic convulsion. Diazepam was used as the standard control in all experiments.

利用光电计数法观察灌胃给予复方酸枣仁油栀子油对小鼠自发活动的影响,以及长期使用药物对小鼠耐受性的影响;利用延长戊巴比妥钠睡眠时间实验和戊巴比妥钠阈下催眠剂量实验,观察复方酸枣仁油栀子油的催眠作用;利用戊四氮诱发小鼠阵挛性、强直性惊厥观察复方酸枣仁油栀子油的抗惊厥作用;本实验用地西泮进行平行对照实验,并进行了组方设计和实验。

3NE、MTT、LDH、ET-1、ICAM-1 and Tie-2experiment show: in the process of oxygen glucose deprivation/reoxygenation ,BMEC have subjected great damagement, I/R groups have significant differences compared with NC groups (p.05);polymorphonuclear leukocyte can aggregrate this injury, I/R+PMN groups have significant differences compared with I/R groups (p.05); after Sivelestat Sodium treatment, the effect of I/R injury has been decreased, I/R+PMN+Siv groups have significant differences compared with I/R+PMN groups (p.05), and NE、MTT、LDH experiment show that the three dose groups there was a significant dose-effect relationship.

3测定NE、MTT、LDH、ET-1、ICAM-1、Tie-2 mRNA均显示:氧糖剥夺/复氧复糖过程能对BMEC造成损伤,I/R组与NC组比较有明显的统计学差异(p.05);中性粒细胞能加重对BMEC的损伤,I/R组与I/R+PMN组之间比较亦有统计学差异(p.05);西维来司钠处理后,血管内皮细胞的损伤明显减轻,I/R+PMN组与I/R+PMN+SIR组比较有统计学差异(p.05),并且NE测定以及MTT、LDH实验提示在西维来司钠三个剂量组之间存在明显的量-效关系,其对BMEC的保护作用有剂量依赖性。

Sivelestat sodium(150mg/kg) can promote the recovery process of ICH rat ethologic change induced by collagenase; It can lessen the occurrence of cerebral edema and display the phonomenon of dose dependency.

结果和结论:(1)西维来司钠(150mg/kg)能促进胶原酶引起的 ICH 大鼠行为学改变的恢复进程;减轻脑水肿的发生并呈剂量依赖性;同时西维来司钠能减轻 ICH 大鼠出血侧脑细胞的病理损伤。

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