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Experiments show that Ang Ⅱ activates JNK mediated by AT〓, and JNK increases transcription activity of c-Jun by phosphorylating c-Jun amido-terminal, and induces expression of c-Fos gene. c-Jun and c-Fos form transcriptional factor activated protein-1 complex. AP-1 may stimulates genes which correlate with cardiovascular remodeling expression, such as transforming growth factor, collagen type Ⅰ and Ⅲ, skeletal muscle α-actin,β-MHC, atrial natriuretic factor.

实验表明,在心肌和血管平滑肌细胞Ang Ⅱ通过AT〓介导激活JNK;JNK通过磷酸化c-Jun氨基末端增加c-Jun的转录活性并诱导c-Fos基因表达,c-Jun和c-Fos蛋白形成转录因子复合物激活蛋白-1(AP-1),并刺激各种心血管重塑相关基因如转化生长因子-β1(TGF-β1)、Ⅰ,Ⅲ型胶原、骨骼肌α-actin、β-MHC(β-myosin heavy chain,β-肌球蛋白重链)、心钠素的表达。

The possibility that afferent nerves may be undergoing sprouting or remodelling has not been investigated.

推测此类患者支配膀胱的传人神经经历了发芽生长和再生重塑的过程,但目前还没有这方面的研究。

AIM To explore the role of proto-oncogenes in the process of airway remodeling in asthma.

目的 观察原癌基因表达在哮喘气道重塑中的作用。

Corporation culture reconstruction is a special and all-pervading problem in Chinese corporation currently.

企业文化重塑是近年来在中国企业界出现的一个特殊而又较具普遍性的课题。

The index of left ventricle pachynsis was lowered after treatment in both groups. The decrease of that in the treating group and diastolc function mprovement were more obvious (P.01). Conclusion: Bu Shen He Luo Fang has explicit hypotensive effects and it can depress ventricle remodeling.One of the mechanisms,we conjectured,are maybe local externalization of HGF.

&补肾和络&细颗粒剂具有明确的降血压及抑制高血压左室重塑的作用,推测其机制之一是通过改变局部HGF的分泌实现的,即通过促进组织HGF分泌,恢复其自身修复能力而逆转心室重塑,发挥其心血管保护作用;同时改善内皮功能,维护心肌组织与内皮的稳定性。

We should strive to form new outlook on students, to remold teachers role and make students an independent and distinctive individuals with developing views.

要努力实现信息技术与语文课程整合下的新型学生观的建立、教师角色的重塑等观念转型,要以发展的眼光完成学生独立、独特主体的培育,教师的角色、地位、学识无疑需要有历史性的超越和重塑

Therefore, collagen metabolism is the center of the extracellular matrix remodeling in intracranial saccular aneurysms, while the essence of the remodeling process is a kind of autoimmunological and inflammatory reaction.

因此,胶原代谢是囊性动脉瘤细胞外基质重塑的核心内容,而重塑过程的实质是一种以细胞免疫为主的免疫炎性反应。

Second, there are four Chapters of this paper: Chapter I Russian History and the fate of intellectual in the 20thcentury, which unscrambles the very historical context reflected by Doctor Zhivago. It refers to the changes of Russian history and politics, the fate of Russian intellectual, the living condition of Pasternak in the torrent times. Chapter II The choice of fate by Russian intellectuals, specificly analyses different choices by different intellectuals, in order to prominent truly noble character of Russianintellectuals; ChapterⅢThe spiritual confusion of Russian intellectuals, analyses the basic formation of their spiritual confusion in the 20th century context of Russian History. It refers to the disjunction between reality and ideal, the tragedy of Hamlet-like character, and Zhivago-like spiritual orphan of Jew. Chapter IV The spiritual remolding of the Russian intellectuals, which profoundly analyzes the relationship among Tolstoyism, Christian faith and belief of the humanitarianism on the blue print of Doctor Zhivago's spiritual experiences, therefore, reflects the tropism of humanitarian value of Russia in the 20th century.

其次,正文部分共分四章:第一章&20世纪俄罗斯历史与知识分子的命运&,主要是从20世纪俄罗斯历史与政治变革、20世纪俄罗斯知识分子的命运、处在时代漩涡中的帕斯捷尔纳克的生存境遇等方面,来(来源:6a6aAB5eC论文网www.abclunwen.com)解读《日瓦戈医生》所反映的特定历史语境;第二章&俄罗斯知识分子的命运选择&,通过具体分析在特定的历史语境中,俄罗斯不同类型的知识分子对于命运的不同选择,以突出真正的俄罗斯知识分子高贵的人格品质;第三章&俄罗斯知识分子的精神困惑&,从理想与现实的脱节、&哈姆雷特式&的性格悲剧、日瓦戈式的&犹太精神孤儿&等方面,具体分析了20世纪俄罗斯历史语境中知识分子精神迷茫的基本形态;第四章&俄罗斯知识分子的精神重塑&,以日瓦戈医生的精神历练为蓝本,对20世纪俄罗斯知识分子的精神重塑与托尔斯泰主义、基督教信仰以及对人道主义的崇信的内在关系做了深刻解剖,从而折射出20世纪俄罗斯社会的人文价值取向。

One has only to note how in the last half-century the movements for women's rights and civil rights have reformulated and renewed American history.

人们只需注意在前半个世纪里,女权和人权运动是怎样重塑和更新了美国历史,就能明白现实不断地在重塑过去。

In remaking itself, China is also remaking the world.

中国在重塑自身的同时,也在重塑着整个世界。

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