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The drug releasing mechanism shown, the sustained-release tablet erose at first and diffuse at last, which depend on the time of HPMC forming the gel.

缓释片释放机理研究表明,其前期HPMC凝胶形成不完全,释放以溶蚀为主;后期形成连续的HPMC凝胶层,释放以扩散为主。

The results showed that along with the reducing of the water content, the glutinosity would wear off and the release in vitro would slower gradually.

对西替利嗪巴布膏剂的含量、体外释放及体外透皮进行测定,表明其含量均匀稳定,体外释放符合Weibull分布,体外透皮符合零级释放方程。

Experiment resultsindicate that, the hydrogen bonds between hydroxyl of PVA and salicylic acid leads to thecompatibility between them. The drug release rate is accelerated with the rise oftemperature and decreased with the increase of drug loadage. The fitting result suggests afirst-order kinetic equation for salicylic acid release.

结果表明:PVA羟基与水杨酸之间氢键作用有利于两者的相容性;随着介质温度的上升,药物的释放速率增加;随着药物装载量的增加,药物的累积释放率降低;PVA水凝胶中水杨酸的释药规律符合一级释放模型。

No entire nitrendipine crystals were observed visually in SEM photos. The results of X-ray diffraction and differential scanning calorimetry analysis indicated that the crystalline form of nitrendipine was highly dispersed in microspheres, so as amorphous state. The drug release rate of microspheres could be controlled with adjusting the ratio of solid dispersion carriers and retarding agents formulated. The agitation speed and temperature of the preparation process have distinct effect on micromeritic properties of microspheres. The release profiles of the microspheres were mainly affected by the stirring rate of paddle, the concentration of SDS and pH of dissolution medium. Cooling speed and time, however, have no evident influence on the drug release rate of the microspheres. The dissolution data showed that the mechanism of drug release from microsphers was mainly diffusion-controlled. The incorporation efficiencies of 3 batches sample were exceed 96. 8%, which implied that the current method was suitable for design sustained-release dosage form for poorly water-soluble drug.

在扫描电子显微镜下观察,在微球内外未发现尼群地平的完整结晶,X-射线粉末衍射和差示扫描量热试验结果也显示,尼群地平已经被高度分散在微球中;微球的释药速度可通过调整处方中固体分散体载体和阻滞剂的比例控制;制备温度和搅拌速度对微球的质量影响较大;溶出仪的搅拌速度,释放介质的浓度和pH对微球的释放有较大的影响;制备过程中的冷却速度和冷却时间对微球的释放行为影响不很明显;方程拟合的结果表明缓释微球的释药行为符合扩散机制;测定三批微球样品的包封率均在96.8%以上,表明该法适合于制备难溶性药物的缓释微球。

The medusa release of all three species of Millepora occurs between April and May. They might have up to 4 bouts during this period, each lasting 1-3 nights. The first medusa appear before dusk, although more were accumulated after sun-set.

研究发现三种火珊瑚释放水母体的季节都在4、5月,而且每种火珊瑚在这两个月期间会有 2~4次释放水母体,每次释放约 1~3个晚上。

Medusa release in Millepora is affected by light and their sex. Male medusae were released prior to females; while dark treatment delayed the release of male and female medusae.

初步研究发现火珊瑚释放水母体与光线和性别有关,雄水母体比雌水母体先释放出来,不论雌、雄群体,置於暗组的火珊瑚释放水母体的巅峰时间,要比置於正常情形下的来得晚。

The velocity of the nonexchangeable potassium release from the soil tested is different at different stages of time.The velocity of the nonexchangeable potassium release is more highly marked in 0~72 hours than in 72~912 hours.

非交换钾释放是粘土矿物层间钾缓慢扩散进入液相的过程,释放速率决定着土壤供钾能力,非交换钾释放动力学性质在土壤供钾能力评价中有着更为重要的作用。

In this paper ,the comparison and analysis of landfill gas migration simulation are presented in assumptions of with landfill gas control system and without landfill gas control system ,and the optimal pumpage of gas pumping well is calculated ,thus the ratio of landfill gas collection is given correspondingly.

利用本数值模型对无控制系统和有控制系统时释放气体运移进行了对比模拟分析,给出了有水平气体控制系统时的优化排气量并得出相应的释放气体收集率,可为填埋场释放气体控制系统的设计及环境影响预测和评价提供理论依据。

The vitro release result which used theophylline as model drug showed, the release behavior can divide to sharp release 、 relaxedly release and equilibrium release periods.

以茶碱为模型药物,模拟体外释放的结果表明,共聚物胶束对茶碱的体外释药可分为突释、缓慢释放、平衡释放三个阶段。

A new trick using Trichogramma brassicae asvectors to transmit Dendrolimus punctatus cypovirus was developed (called"Biological missiles Dp-Ⅰ") to control the Dendrolimus punctatus in the field. Sincethen, we collect the single caterpillar from both areas used Dp-Ⅰand controlled areasevery year, and A nested-PCR-based assay for the detection of those samples wasdeveloped, The results showed that the positive reaction rate of the first year is 40~70%; and second year is 30~80%, on the other hand, the positive reaction rate of thecontrolled areas are 10~40%and 10~20%.

第二章对马尾松毛虫质型多角体病毒的流行病做了初步的调查,应用巢式RT-PCR方法检测从野外释放&生物导弹Dp-Ⅰ&的林区采集马尾松毛虫单虫样本,结果发现:2006年释放&生物导弹Dp-Ⅰ&的王福店林区的松毛虫体内DpCPV阳性率为40~70%,平均阳性率为58%,相应对照区的阳性率为10~40%,平均阳性率为24%;2005年释放&生物导弹Dp-Ⅰ&的丁家畈林区松毛虫体内DpCPV阳性率为30~80%,平均值也为58%,相应对照区的阳性率为10~20%,平均值为16%。

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