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醛固酮

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Fifteen patients undergoing hysteromyomectomy with 0 75% bupivacaine epidural anesthesia were studied to observe the alterations of the levels of plasma atral natriuretic peptide, renin activity, angistensin Ⅱ and aldosterone systems.

研究了15例子宫肌瘤切除术患者应用0.75%布比卡因硬膜外麻醉血浆心钠素和肾素活性、血管紧张素Ⅱ-醛固酮系统的变化及相互调控。结果表明,血浆ANP水平在麻醉10min后各时点明显低于麻醉前(P<0.05),PRA在麻醉10min后亦明显低于麻醉前(P<0.01),而AⅡ和AL无显著改变(P>0.05)。

Cardiac hypertrophy and extracellular matrix remodeling happened as a result of chronic overrange of pressure in heart and hypervolaemia which lead to damage of relaxation and compliance of heart.Drugs including renin-angiotensin converting enzyme inhibitor,angiotensin receptor blocker,aderergic receptor blocker,aldrosteron antagonism,tatins endothelin receptor blocker pancreatic kiniogenase and calcalium channel blocker,can delay or reverse the remodeling by several mechanisms.

主要表现为心脏在慢性超负荷的压力、容量作用下发生的病理改变致使左室肥厚组织胶原结构发生改变,导致心肌顺应性降低,舒张功能受到损害;作用于肾素-血管紧张素系统的药物及肾上腺素受体阻滞剂、醛固酮拮抗剂、他汀类药物、内皮素受体拮抗剂、胰激肽原酶、钙通道阻滞剂等药物通过不同途径和机制延缓和逆转左心室重构。

Plasma concentration of both Ang Ⅱ and ALDO returned to predepletion levels after third sodium depletion 5 days,but ANP was inhibited.

大鼠经3次钠缺乏恢复正常生活5d时,对血管紧张素Ⅱ、醛固酮的分泌量没有影响,而使心房肽的分泌受到抑制。

objectives: by building a long time and high-intensity and endurance-trained and exhausting exercise model in mice, testing the activities of gsh-px, mn-sod, cu-zn-sod, gsh, content of mda, serum cortisol, aldosterone, atrial natriuretic and the exhausting time, the effects of rubia cordifolia l on metabolism of free radical of heart are studied in trained mice.

摘 要:目的:通过分析耐力训练后一次力竭性运动大鼠部分自由基指标的变化来探讨补充茜草提取物抗氧化、提高机体抗疲劳能力的可能机制。方法:通过建立大鼠递增大强度耐力跑台训练实验模型,测定了大鼠力竭时间、心肌织某些生化指标和抗氧化酶活性一以及血清皮质醇、醛固酮、血浆心钠素影响。

Objective To observe the effect of nesiritide glycerol trinitrate, dobutamine on renin and aldosterone in patients with intractable heart failure.

目的 观察在应用新活素、硝酸甘油、多巴酚丁胺治疗失代偿心力衰竭伴轻度肾功能不全时对肾功能、肾素、血管紧张素、醛固酮系统的影响。

Methods 42 cases of intractable heart failure were dividedinto 3 groups, and received intravenous infusion of nesiritide (12 cases), glycerol trinitrate (15 cases), and dobutamine (15 cases) respectively. Plasma rennin activity, aldosterone and angiotensin II were measured before and after infusion in 24h and 48h.

42例患者分成三组:甲组应用rhBNP;乙组应用硝酸甘油;丙组应用多巴酚丁胺静脉注射,同时检测血浆肾素活性、血管紧张素II、血浆醛固酮浓度,并在24、48h再次复查上述指标,复查左室射血分数,进行比较。

Classically, Ang Ⅱ is well known to cause potent increases in systemic and local blood pressure via its vasoconstrictive effect, to influence renal tubules to retain sodium and water, and to stimulate aldosterone release from the adrenal gland.

众所周知,Ang Ⅱ通过它的血管收缩效应导致系统和局部的血压增高并影响肾小管的钠水潴留以及刺激肾上腺的醛固酮释放。

It blocks that part of the renin-angiotensin-aldosterone hormonal system that narrows constricts the peripheral arteries .

一方面,它可以阻断肾素-血管紧缩素-醛固酮的激素系统,该系统会引起周围动脉的狭窄。

MeSH ] Shock, hemorrhagic; Captopril; Lactates; Glucose; Aldosterone

主题词]休克,出血性;卡托普利;乳酸盐类;葡萄糖;醛固酮

Chronic and persistent hypertension will activate circulatory and focal rennin-angiotensin-aldosterole-system, which plays an important role in hypertension development and target organ detriments.

高血压时持续的压力负荷增加可激活一系列神经-体液因子,如循环和局部的肾素-血管紧张素-醛固酮系统在高血压的发生、发展和靶器官损害过程中具有重要的作用。

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