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Methods: YTLP and aspirin were introduced to treat the edematous ears of mice induced by xylene and swollen toes of mice induced by carrageenin, and to relieve the pain in mice induced by heat and acetic acid.

以阿司匹林为对照药物,将一贴灵贴剂用于治疗二甲苯所致的小鼠耳肿胀和角叉采胶所致的大鼠足趾肿胀,以及热和醋酸所致的小鼠疼痛,测量肿胀度、痛阈值及扭体次数。

Methods:Different doses of CQG were given to mice with swelling feet induced by acetic acid, cotton balling granulation ,and carrageenin.

采用小鼠醋酸扭体法、大鼠棉球肉芽肿法和角叉菜胶所致大鼠足肿胀方法。

It could also suppress paw edema induced by carrageenin in rat and writhing induced by acetic acid in mice, but has no effect on the ear swelling caused by dimethylbenzene and cotton granulation hyperplasia and latent period of pain reaction in tail immersion test in mice.

对角叉菜胶致大鼠足肿胀和醋酸致小鼠扭体反应有一定的抑制作用,但对二甲苯致小鼠耳肿胀、小鼠棉球肉芽肿增生、小鼠温浴致痛反应潜伏期无明显影响。

The Nvzhendan Granula antiinflammatory effect was demonstrated in rats using inflammatory models including auricle edema induced by xylene in mice,and paw edema induced by carrageenin.

采用醋酸和热板致痛法观察复方女真丹颗粒的镇痛作用;采用二甲苯致小鼠耳肿胀、角叉菜胶致大鼠足肿胀炎症模型观察复方女真丹颗粒的抗炎作用。

Result: Xinhuang Tablet had very significant inhibition on acute and chronic inflammation in model of ear edema induced by croton oil in mice, paw swelling induced by carrageenin in rats, granuloma induced by cotton pellet in rats and very significant analgesic effect on thermal and chemical stimulation in model of writhing body response induced by acetic acid in mice and tail flicking in rats.And at the same doses, Xinhuang Tablet hadn't significant difference from ig administration.

结果:新癀片外涂给药对小鼠耳肿、大鼠角叉菜胶足肿、棉球肉芽肿等急、慢性炎症有非常显著的抑制作用;对大、小鼠水浴甩尾、小鼠醋酸扭体等温热刺激、化学刺激引起的疼痛有非常显著的镇痛作用,且在相同剂量下,外涂给药和ig给药的作用无明显差异。

Methods Antipyretic action of CSC was observed on rabbit fever models induced by lipopolysaccharide and rat fever models induced by baker's yeast. Rat models with pedal swelling induced by carrageenin, mouse models with auricle swelling induced by dimethylbenzene and mouse models with celiac capillary hyperpermeability induced by acetic acid were used to observe the anti- inflammatory action of CSC. Its acute toxicity in mice was also evaluated.

方法]采用细菌脂多糖致家兔发热、啤酒酵母致大鼠发热动物模型,观察穿心莲软胶囊的解热作用;采用角叉菜胶致大鼠足肿胀、二甲苯致小鼠耳肿胀和醋酸致小鼠腹腔毛细血管通透性增加的动物模型,观察穿心莲软胶囊的抗炎作用,并对小鼠进行该制剂的急性毒性试验。

The Xiaojingtong antiinflammatory effect was demonstrated in rats using inflammatory models including auricle edema induced by xylene in mice,and paw edema induced by carrageenin.

结果复方消经痛胶囊2.0,1.0 g/kg可明显减少醋酸所致疼痛模型小鼠的扭体次数(P<0.05)。2.0 g/kg在给药后90 min可明显提高热板致小鼠疼痛阈值, 1.0,0.5 g/kg组则在给药后120 min痛阈值明显提高(P<0.05)。

Results All Qianliean groups could inhibit the inflammation caused by carrageenin, increases the density of prostate tissue lecithin, and could suppress the lint ball granuloma formation obviously and has the obvious inhibitory action on the blood capillary permeability increasing.

结果 前列安颗粒小、中、大剂量均可抑制角叉菜胶所致大鼠前列腺非细菌性炎症,增加前列腺组织内卵磷脂小体密度,并可明显抑制棉球肉芽肿形成;对二甲苯所致小鼠炎症均有明显抑制作用;可明显抑制0.6%醋酸所致小鼠腹腔毛细血管通透性的增加。

Methods The analgetic effect was demonstrated using pain models induced by acetic acid and hot board on mice. The Nvzhendan Granula antiinflammatory effect was demonstrated in rats using inflammatory models including auricle edema induced by xylene in mice,and paw edema induced by carrageenin.

采用醋酸和热板致痛法观察复方女真丹颗粒的镇痛作用;采用二甲苯致小鼠耳肿胀、角叉菜胶致大鼠足肿胀炎症模型观察复方女真丹颗粒的抗炎作用。

The results shown that PA (0.5, 1.0 g/kg, p.o.) and carvacrol (2, 10, 20 mg/kg) significantly decreased the acetic acid induced writhing responses and licking time in the late phase of formalin test.

实验结果显示,在镇痛实验中左手香水抽提物 0.5, 1.0 g/kg)及香芹酚(2, 10, 20, mg/kg)均可减少由醋酸所引起之扭体次数及福马林引起之后期舔足时间。

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