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酸酪蛋白

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Another interesting phenomenon is that when CaLP and p21 are co-transfected, the expression of p21 can stimulate CaLP translocate from cytoplasm to nucleus. By using methods of bioinformatics, point mutation and flow cytometry, we confirmed the importance of Y139 in the nuclear-cytoplasmic trafficking of CaLP.

激光共聚焦实验还发现当p21过表达时能够引起CaLP从细胞质向细胞核的转移,通过生物信息学方法,免疫共沉淀实验和流式细胞分析表明,CaLP的139位酪氨酸残基存在着较高的磷酸化潜力且在CaLP的核质穿梭和蛋白相互作用中起到了重要的作用。

But the emulsifying activity of conjugates at higher NaCl concentrations is not increased compared with soy protein isolates, although the emulsifying stability is more superior to that of sodium caseinate.

但在较高NaCl浓度时的乳化活性与大豆分离蛋白相比没有明显的改善,其乳化稳定性则明显优于酪朊酸钠。

This specific preparation methods including: parathion of the initial reaction in acid and zinc metal in the common under redox reaction, a product of the reduction of parathion - parathion, with the sodium nitrite in the cold under diazotization reaction, and bovine serum protein tyrosine on the o-hydroxy combination of the adult immune original and immune rabbit polyclonal antibody preparation.

本发明制备方法具体包括:以对硫磷为反应初始物,在酸和金属锌的共同参与下进行氧化还原反应,得对硫磷还原产物对氨基对硫磷,再与亚硝酸钠在低温下进行重氮化反应后,与牛血清蛋白酪氨酸上羟基的邻位结合,制备成人工免疫原,并免疫新西兰大白兔制备多克隆抗体。

Among them, there were 7 necessary amino acid and total content reached to4.746%, occupying 38.86% of all amino acid. The tryptophan, tyrosine and cystine were notmeasured. The content of isoleucine and histidine were relative high as to the fluting-body ofSuillus aeruginascens,Lactarius deliciosus, Cortinarius caerulescens, Cantharellus cibarius, andthe mineral elements content of C.

对紫红丝膜菌子实体的营养成分做了系统分析,结果显示紫红丝膜菌子实体含糖量较高,总糖含量高达47.76%、多糖4.5%、粗蛋白9.76%、粗脂肪5.4%,水分11.2%;紫红丝膜菌子实体含有15种氨基酸,总量为12.214%,其中含有人体必需氨基酸7种,含量为4.746%,占总氨基酸含量的38.86%,色氨酸、酪氨酸和胱氨酸在丝膜菌子实体中未检测到。

CML is cytogenetically marked by the philadelphia chromosome, which originates from a reciprocal translocation between chromosome 9 and 22 and is molecularly marked a chimeric bcr-abl gene, resulting from juxta-positive of the abl proto-oncogene on chromosome 9 with the bcr gene, which is normally located on chromosome 22. The chimeric bcr-abl gene expression an 8. 5kb hybrid mRNA transcript giving rise to a 210-KD fusion protein (P210〓) with increased tyrosine kinase activity. P210〓 plays a key role in the pathogenesis of CML. The continuous cell line K562 was established from the pleural effusion of a 53-year-old female with CML in terminal blast crisis, and was a human erythroleukemia line, contained Ph chromosome.

绝大多数慢粒患者白血病细胞中具有Ph染色体,是由9号染色体长臂3区4带和22号染色体长臂1区1带相互易位形成,即t(9;22),使位于9q〓的c-abl原癌基因在第二外显子的5'端断裂并易位到22 q〓的M-bcr基因第2或第3外显子的3'端,形成异常的bcr-abl嵌合基因,该基因转导出异常的mRNA,编码并翻译出P210蛋白,该蛋白具有很强的酪氨酸激酶活性,使粒细胞发生恶性增殖。K562细胞属于慢粒急变、红白血病细胞株,具有Ph染色体。

Another interesting observation was that nonstructural protein 3 (NS3) was able to interact with Src and showed tyrosine phosphorylation.

观察到另一个有趣现象,即非结构蛋白3 (NS3)与Src蛋白可相互作用,导致酪氨酸磷酸化。

Surprisingly, overexpression of IRS-1 in A549 cells completely blocked TGF-β1–induced EMT and cell migration, inhibited TGF-β1–mediated expression of snail and slug genes, and abolished TGF-β1–mediated repression of E-cadherin promoter activity.

宋建国研究组发现了TGF-β1在诱导EMT过程中下调IRS-1酪氨酸磷酸化和蛋白水平的现象,并显示了较高的IRS-1的蛋白水平在抑制TGF-β1诱导的EMT和维持上皮细胞特征中的作用。

Objective To investigate whether the tyrosine protein kinase Src and Fyn were involved in the neuronal cell death induced by cerebral ischemia followed by reperfusion.

目的 观察胞内可溶性酪氨酸蛋白激酶Src、Fyn蛋白对脑缺血再灌注后海马CA1区神经细胞存活的影响。

Both Src and Fyn play an important role in neuronal death induced by cerebral ischemia followed by reperfusion, while Src dominate over Fyn in the process.

胞内可溶性酪氨酸蛋白激酶Src、Fyn蛋白的含量降低对脑缺血再灌注后海马神经细胞有明显保护作用,且以Src作用更为明显。

Studies in neuropsychopharmacology and molecular neurobiology indicate that neurotransmitters and its receptors play important roles in alcohol abuse and addiction, and post-receptor signal transduction pathways, including cyclic adenosine 3', 5'-monophosphate-protein kinase A, phosphoinositide, Ca(superscript 2+)-calmodulin, phospholipase D and tyrosine kinase Fyn signaling cascade.

神经精神药理学和神经分子生物学研究表明,酒精滥用和成瘾不仅与中枢神经系统的神经递质及其相关的受体有关,而且,受体后的信号转导通路参与了酒精依赖的形成过程。其中包括环磷酸腺苷-蛋白激酶A、磷脂酰肌醇、Ca(上标 2+)-钙调蛋白、磷脂酶D以及酪氨酸激酶Fyn等信号途径。

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