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In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果,本研究提示:夏季和低龄是托吡酯引起泌汗障碍的主要危险因素,而托吡酯剂量对泌汗(来源:A44B8787C论文网www.abclunwen.com)功能的影响较小;托吡酯可以抑制小鼠汗液的分泌,小鼠的年龄并不影响这种抑制作用,但托吡酯对小鼠体温无明显影响;托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗;托吡酯不影响汗腺形态及Na,K-ATP酶活性;汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关,而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

Maleic anhydride is a important organic raw, the research of determination the content of it has practical meanings.

顺丁烯二酸酐是一种重要的有机原料,对其含量的测定有很大意义。

Therefore, determination the content of maleic anhydride in different conditions is researched.

因此,研究了各种条件下测定顺丁烯二酸酐的含量。

With the unceasing development of polycarboxylate superplasticizers, maleic anhydride is used more and more in its synthesis.

随着聚羧酸盐减水剂的不断发展,马来酸酐在其合成中的应用也越来越多。

The supply and demand for trimellitic anhydride at home and abroad were analyzed, and previewed its demand in several years to come.

分析了国内外偏苯三酸酐的市场供需状况,并对我国今后几年的需求进行了分析和预测。

The way that determination the content of maleic anhydride has been reported is not accurate.

目前,文献上提到的顺丁烯二酸酐含量测定方法的误差较大。

For this, the company had reduced Tai Kerong to be opposite before of suitable anhydride market calculate data.

为此,泰可荣公司已经下调了先前对偏苯三酸酐市场的预测数据。

The way that determination the content of maleie anhydride has been reported is not accurate.

目前,文献上提到的顺丁烯二酸酐含量测定方法的误差较大。

The kinetics on the hydrogenation of maleic anhydride to succinic anhydride has been studied.

在反应条件考察的基础上,对顺酐均相加氢生成琥珀酸酐的反应动力学进行了研究。

In this article, Fe3-Al3 was first used to catalyze copolymerization of maleic anhydride and isoprene.

研究了双金属体系Fe3-Al3催化马来酸酐与异戊二烯的共聚反应。

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On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面,更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值,分为几个相等的区间作为横轴,并将各区间内所测定值依所出现的次数累积而成的面积,用柱子排起来的图形,也叫做柱状图。

You rap, you know we are not so good at rapping, huh?

你唱吧,你也知道我们并不那么擅长说唱,对吧?