酸基

Methods 4-Hydroxybenzonitrile (2) as the starting material was transformed to 4-hydroxy-thiobenzamide (3) via thioformylation. And ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate (4), which was synthesized via cyclization from 3, was treated with hexamethylenetetramine to generate the intermediate ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate (5). The target compound febuxostat (1) was obtained from 5 by etherification, cyanidation, hydrolysis.

以羟基苯腈为原料，经硫代甲酰化得到对羟基硫代苯甲酰胺(3)，3经环合得到2-（4-羟基苯基）－4-甲基－噻唑－5-羧酸乙酯(4)，4与乌洛托品反应，得到中间体2-（3-甲酰基－4-羟基苯基）－4-甲基－噻唑－5-羧酸乙酯(5)，之后再经醚化、氰化、水解得到目标产物(1)。

Results: Tyr486Asp missense mutation in Exon 5 of UGT1A1 gene was found and homozygote of the mutation was confirmed in the proband.

结果：该先证者UGT1A1基因的第5外显子第486密码子发生了T→G碱基的错义突变，导致了酪氨酸变成了天门冬氨酸(Tyr486Asp)。

Our company treasures technical innovation and development of new products. On the basis of stable food grade,pharmagrade glycine,we have also developed compound amino acid,4pyridone,hydantoin and Nbenzylglycine ethyl ester etc.

本公司十分注重技术创新和新产品开发，在稳定食品级，医药级甘氨酸等老产品生产的基础上，又开发了蚕蛹复合氨基酸，4羟基吡啶，海因，N苄基甘氨酸乙酯等产品。

A catalyst composition for the polymerization of propylene comprising one or more Ziegler-Natta procatalyst compositions comprising one or more transition metal compounds and one or more esters of aromatic dicarboxylic acid internal electron donors; one or more aluminum containing cocatalysts; a selectivity control agent comprising at least one silicon containing compound containing at least one C1-10 alkoxy group bonded to a silicon atom, and one or more activity limiting agent compounds comprising one or more aliphatic or cycloaliphatic carboxylic acids; alkyl-, cycloalkyl- or alkyl-ester derivatives thereof; or inertly substituted derivatives of the foregoing.

一种用于丙烯聚合的催化剂组合物，所述催化剂组合物包括：一种或多种齐格勒-纳塔主催化剂组合物，该主催化剂组合物包括一种或多种过渡金属化合物和一种或多种芳族二羧酸酯内部电子给体；一种或多种包含铝的助催化剂；选择性控制剂，该选择性控制剂包括至少一种包含硅的化合物，该化合物包括至少一种与硅原子连接的C 1-10 烷氧基；和一种或多种活性限制剂化合物，该活性限制剂包括一种或多种脂族或脂环族的单或聚羧酸类、其烷基-、环烷基-或烷基-衍生物、或上述惰性取代的衍生物。

The theoretical deduction and many experiments discovered that reaction of isocyanate with water is second order in room temperature, and the water and isocyanate are first order to the rate respectively.

通过理论推导和大量实验证明，室温下异氰酸酯与水的反应可以使用准二级方程描述，水和异氰酸酯基的分级数都是1。

The research indicated that under the compound use of hydroquinone and methyl quinone or independent use of phenothiazines or nitrogen oxygen free radical made the polymerization retarder, opposite-methyl-phenylsulfon made the esterification catalyst, toluol made the backflow including water condition, the acid mellowly compared to when it was 1.15, the production rate of the synthesis methylacrylic acid polyethylene glycol single methyl ether (400) ester may achieve 98.9%, was extremely similar to the overseas product functional group structure.

研究表明，在氢醌、甲醌复合使用或者单独使用吩噻嗪、氮氧自由基哌啶酮作阻聚剂，对甲苯磺酸作酯化催化剂、甲苯作回流带水的条件下、酸醇比为1.5时，合成的甲基丙烯酸聚乙二醇单甲醚(400)酯产率可以达到98.9%，与国外产品官能团结构十分相似。

From the reaction mechanism, which involved formation of benzodiazepinium ethoxycarbonylmethylate, the reaction mechanism, which involved formation of benzodiazepinium ethoxycarbonyl- methylate followed by cycloaddition reaction, was tentatively proposed.

通过研究反应过程中分离出的副产物反丁烯酸二乙酯III和4，5-二氢吡唑-3，4，5-三羧酸乙酯IV，初步提出了反应经过乙氧羰基甲基化苯并二氮杂卓翁中间体V再发生环加成反应的机制。

Glucuronidase and lysozyme release was quantitated by enzyme reactions in which phenolphthaleinglucuronic acid and Micrococcus Lysodeikticus were as the substrates, respectively.

以酚酞葡糖醛酸和Micrococcus Lysodeikticus为基质的酶反应法测定β-葡糖苷酸酶和溶菌酶的释放量。

Some samples of TiO_2 nanocomposite material doped with W~(6+) were prepared by Sol-Gel process,The morphology and phase composition of TiO_2 film were studied by scanning electron microcopy,X-ray diffraction and ultraviolet-visual reflection spectrum.

以钛酸丁酯和钨酸钠为原料，采用溶胶-凝胶法在不同基体材料上制备了掺杂W6+的TiO2纳米复合材料。

Owing to the good stability in light, heat and chemical characteristics, the rare earth-doped molybdate is a good kind of luminescent material, but there are few reports on it.

稀土钼酸盐发光材料由于具有良好的光热稳定性和化学稳定性，是一种很好的发光基质材料，但关于稀土钼酸盐发光材料的研究却少有报道。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。