酸基

By means of covalent coupling with the activation of 1-ethyl-3-(3-dimethyllaminopropyl) carbodiimide hydrochloride and N-hydroxysulfosuccinimide.

利用自组装技术将三巯基丙酸固定在金电极上，以1-乙基-3-（3-二甲氨基）碳二亚胺盐酸盐和N-羟基硫代琥珀亚胺作为活化剂，将甲基对硫磷抗体以共价键形式固定在三巯基丙酸自组装单分子膜修饰的金电极上，制备了一种免疫传感器。

Single chain bolaamphiphile containing cinnamyl moiety [4-(ω-hydroxydecanyloxy)(ω-hydroxydecanyl) cinnamate, abr. HDC] was designed and synthesized.

制备了一种含肉桂酸基团的Bola型两亲分子HDC4-(10-羟基癸氧基-10-羟基癸氧基肉桂酸酯。

The UV and IR spectroscopic studies of the monomer films showed that the photoreaction ratio of monomer (about 50%) was higher than the corresponding photosensitive polymer (about 10%, PVCi). The polarized IR spectra proved that obvious anisotropic absorption was displayed in the irradiated photosensitive film. With polarizing microscopy method, we found that these kinds of photoalignment films exhibited good alignment ability, and the stability of the photoalignment film could reach about 100℃. 2 A photosensitive self-assembled monolayer was fabricated that contained photo-cycloadditable groups, such as, coumarin and cinnamate. The reaction process were detected by contact angle method because the IR absorption of monolayer was very weak. The photosensitive self-assembled monolayer promote uniform alignment of nematic liquid crystals by LPUV, and it thermal stability could reach about 130℃. 3 A cationic bolaform amphiphiles was synthesized that had two photosensitive double bonds, and can be polymerized by ultraviolet. A layer-by-layer self-assembled deposition film was prepared in aqueous solution by using this material and poly (sodium 4-styrenesulfonate). The UV-Vis. spectra proved that the multilayers film was uniform and layer-by-layer. When LPUV irradiated the film, the photopolymerizable double bond underwent [2+2] cycloaddition, and the production of the reaction distributed along the polarized direction of incident LPUV. Polarized UV-Vis. spectra indicated that the irradiated self-assembled multiplayer film was anisotropic, and the dichromic ration is about 0.09, it is higher than the spin-coating method of photosensitive polymer or monomer. We used this anisotropic film as alignment layer of nematic liquid crystals, and obtained a uniform and stability alignment result, the static contrast ratio is about 100, which is very close to application of liquid crystal device. This thesis is an instance that the photochemical material was used in the physics region of liquid crystals, the route that was from photosensitive monomer, self-assembled monolayer film to self-assembled multiplayer film was undergone, by this logical research method photoailgnment of liquid crystal was extended and consummated.

围绕上述思路开展了如下工作：1合成了三种可进行光二聚反应的光敏小分子单体，LPUV 辐照制作了光控取向膜；用紫外-可见光谱法和红外光谱法分析了薄膜中的光化学反应，发现小分子的光反应程度可达到50%以上，至少比光敏高分子高出5倍；薄膜的偏振红外光谱证实，经过LPUV 辐照后薄膜出现了明显的各向异性；将小分子光控取向膜制成液晶器件，在偏光显微镜下观察看到均匀一致的液晶取向；并且热稳定性达到100℃左右，接近实用化要求。2制备了含肉桂酸、香豆素基团的自组装单层膜；采用接触角的方法监测自组装反应的动力学过程；紫外-可见光谱证实了自组装单层膜在石英基板表面形成；自组装单层膜经LPUV 辐照后能诱导液晶均匀取向，而且热稳定性可达130℃，热稳定性进一步提高。3合成了含有光敏双键的双季铵盐，在水溶液状态下将它和聚乙烯基苯磺酸钠沉积生成layer-by-layer 自组装多层膜，紫外-可见光谱证实这是一个逐层均匀的沉积；在LPUV 照射下，自组装膜中的光敏双键按照偏振方向发生[2+2]环加成反应，形成取向膜，用二向色性值评价的分子取向度高于高分子及小分子光控取向膜的水平；实验证明用自组装多层膜制成的液晶器件亮暗态均匀，静态对比度约为100，达到实用化器件的水平。

Applied dodecencylsuccinic acid and diethanolamine as raw materials,dodecencylsuccinic acid diethanolamide was prepared.

以十二烯基丁二酸(T746)和二乙醇胺为原料合成了十二烯基丁二酸二乙醇酰胺防锈剂，探讨了原料质量配比、反应温度、反应时间等对产品性质的影响。

Based on reviewing of functionalization of saturated carbon by catalytic oxidation with metalloporphyrins and metal phthalocyanines as a mimic of the enzyme cytochrome P-450, two reaction systems of which one was the preparation of 4, 4'-dinitrostilbene-2, 2'-disulfonic acid from 4-nitrotoluene2-sulfonic acid and the other was the preparation of 4, 4'-bis (dimethylamino -diphenyl) phenylmethanol from 4, 4'-bis (dimethylamino-diphenyl) phenyl methane , were specifically studied as carfunctionalization and oxyfunctionalization of saturated carbon.

本文在全面综述金属卟啉和金属酞菁类模拟细胞色素P-450酶催化剂催化氧化饱和碳原子功能化的基础上，选择由4-硝基甲苯-2-磺酸制取4，4'-二硝基二苯乙烯-2，2'-二磺酸和由4，4'-二苯基甲烷制取4，4'-二苯基甲醇两个反应体系进行饱和碳原子碳功能化和氧功能化的具体研究。

This dissertation is mainly focused on the reactivity of methylenecyclopropanes and comprises six parts. 1 The reactions of methylenecyclopropanes with phenylsulfenyl chloride, phenylselenyl chloride and diphenyl diselenide; 2 The coupling reactions of the ring-opening products derivated from methylenecyclopropanes; 3 The palladium-catalyzed ring-enlargement of mono-aryl group substituted methylenecyclopropanes to cyclobutenes. 4 The gold-catalyzed domino ring-opening and ring-closing hydroamination of methylenecyclopropanes with sulfonamides; 5 The Lewis acid-catalyzed reactions of mono-aryl group substituted methylenecyclopropanes with diethyl ketomalonate in the presence of water; 6 The iodobenzene diacetate mediated novel 1,3-dipolar cycloaddition of methylenecyclopropanes, vinylidenecyclopropanes, and methylenecyclobutane with phthalhydrazine.

本论文主要研究了亚甲基环丙烷类化合物的一些化学反应性能，共由以下六部分组成：1、亚甲基环丙烷类化合物与苯硫氯、苯硒氯及二苯基二硒的反应；2、亚甲基环丙烷类化合物开环产物的偶联反应；3、单芳基取代的亚甲基环丙烷类化合物在钯催化剂作用下的扩环反应；4、金化合物催化磺酰胺对亚甲基环丙烷类化合物的串联开环关环氨氢化反应；5、路易斯酸催化亚甲基环丙烷类化合物与丙酮二羧酸二乙酯在有水存在下的反应；6、醋酸碘苯促进的亚甲基环丙烷类化合物、亚乙烯基环丙烷类化合物及亚甲基环丁烷类化合物与邻苯二甲酰肼的新型1，3-偶极环加成反应。

Based on this result, a new technology is suggested, that is by regulating the effective sulphonating contents of 1-amino-anthraquinone, adjusting the concentration of sulfuric acid to hydrolyze 1-amino-anthraquinone disulfonic acid conversing to 1-amino-anthraquinone -2-sulfonic acid, and briminating the hydrolyzed product in 100% sulfuric acid, 87% yield of Bromamino-acid was achieved, 10% higher than the conventional method prepared by "oleum method".

此新工艺，溴氨酸在产物中含量可达87％，比常规的发烟硫酸法生产溴氨酸提高了10％，质量和收率都接近或达到溶剂法生产的水平。 1，5-二硝基蒽醌和1，8-二硝基蒽醌是生产分散蓝56、分散蓝73等一系列分散染料重要中间体。

It had the structuraL arrangement of four conserved cysteine residues C~(56, C~(87), C~(98) and C~(118) with two disuLphide bonds towards the carboxyL terminusas found in Large known cystatins, however there is a cysteine residue C~(56 in the different Location from the others, which was removed to N-terminus.

但大黄鱼的四个半胱氨酸残基中只有3个是与其它物种的位置是一致，另有一个半胱氨酸残基C~(56向N-端偏移，这有可能影响其空间结构的形成。

Using 2-bromo-ethanesulfonic acid sodium salt ,α,ω- binary primary amine and dodecanoic acid as the main raw materials, drawing support from two-step synthesis of experiments—Alkylated reaction and Schotten-Baumann acylation, A series of LAS(12-s-12) gemini surfactants were synthesized.

并以2-溴乙基磺酸钠、α，ω-二元伯胺、月桂酸等为主要原料，借助胺基的烷基化和Schotten-Baumann酰基化反应制备了α，ω-烷撑-双钠盐LAS(12-s-12)表面活性剂，联结基团为亚甲基—(CH2)s—(S=2，4，6，8，12)，取得以下进展

It was found from the structure-electrochemical studies of cytochrome c that (1) the secondary and tertiary structural changes of cytochrome c are greatly influenced by the reductions of tyrosine residues and iron ions in heme;(2) the reduction reaction dose not induce the configuration transition;(3)α helix, parallel β sheet, antiparallel β sheet and random coil take part in the complex secondary structural transitions;(4) mechanism and parameters about the electroreduction have also been obtained.

在细胞色素c的结构-电化学研究中发现：（1）细胞色素c的二级和三级结构受电场和酪氨酸残基及血红素中Fe的电化学还原的影响，其中酪氨酸残基还原的影响较大；（2）细胞色素c的电化学还原没有发生构型转化现象；（3）细胞色素c参与二级结构变化的构象有α螺旋，平行β折叠，反平行β折叠和无规卷曲；各组份随电位的变化复杂；（4）获得细胞色素c电化学还原的机理和参数

By the time of its fall, most of the prisoners were writers who had written against the corruptions of the government.

到它被攻陷的时候，里面多数的犯人是写了反对政府贪污文章的作家。

The most obvious variation to ovum morphological character was that the color was changed from light green to sepiaceous in embryonic development, and all the ovums were almost hatched after 96h.

在胚胎发育过程中卵的形态特征最明显的变化是颜色从淡绿到深褐色，卵在发育96h后卵基本全部孵化。