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Water,c12-20 acid peg-8 ester,caprylic/capric triglyceride,proplylene glycol,ppg-15 stearyl ether,chondrus crispus,iris germanica(orris extract/cells),centaurea cyanus,macadamia ternifolia,buxus chinensis,triethanolamine,potassium cetyl phosphate,butyrospermum parkii,c12-13 alkyl lactate,carbomer,phenoxyethanol,methylparaben,imidazolidinyl urea,glyceryl hydroxystearin,tocopheryl acetate.retinyl palmitate,sodium hyaluronate,biosaccharide gum-1,propylparaben,disodium edta,ethylparaben,pentadecalactone,hydroxystearic acid,tetradecyloctadecanoic acid,tetradecyleicosanoic acid,hexadecyleicosanoic acid,butylparaben,isobutylparaben,chlorhexidine digluconate,tocopherol,lecithin,ascorbyl palmitate,glyceryl stearate,glyceryl oleate,BHT,citric acid.

水,C12-20 酸 PEG-8酯,辛酸/癸酸三酸甘油酯,丙二醇,PPG-15 硬脂基醚,卡拉胶萃取,德国鸢尾花提取物/细胞,矢车菊提取物,澳洲坚果油,荷荷巴油,三乙醇胺,十六烷基磷酸钾,牛油果,c12-13烷醇乳酸酯,卡波姆,苯氧乙醇,羟苯甲酯,尿素醛,甘油羟基硬脂酸酯,醋酸盐维他命E,维他命A酯,透明质酸钠,多醣物质,羟苯丙酯,乙酸乙二胺二钠,羟苯乙酯,环十五内酯,羟基硬脂酸,十四烷基十八烷酸,十四烷基二十烷酸,十六烷基二十烷酸,羟苯丁酯,对羟基苯甲酸异丁酯,洗必泰葡萄糖酸盐,维生素E,卵磷脂,抗坏血酸棕榈酸酯,甘油硬脂酸,甘油油酸酯,BHT,柠檬酸。水:几乎所有护肤品成分第一位都是水。辛酸/癸酸三酸甘油酯:润滑剂、扩散剂,棕榈油/椰子油衍生物

The influences of different surfactants (sodium dodecyl sulfate, sodium cholate and sodium deoxycholate), different electrolytes (sodium phosphate monobasic, sodium tetraborate and 3-cyclohexylamino-1-propane sulfonic acid), buffer pH and organic modifiers on the determination of sialic acid were studied.

其次建立了一种测定唾液酸的在线富集CZE法,该方法用40 mM磷酸二氢钠为缓冲溶液电解质,通过将样品溶解在乙腈:水=2:1的样品基体中,进样时间增加到100 s来达到样品富集的效果,并考察了样品基体中乙腈浓度和进样时间对富集效果的影响,研究了用硼砂或3-环己胺-1-丙烷磺酸作为电解质、缓冲溶液pH值和有机修饰剂的加入对唾液酸检测的影响。

The method is characterized in that: mixture of macromolecular dihydric alcohol and a dihydroxybutyl-terminated polydimethylsiloxane is dehydrated, added with diisocyanate for reaction, then added with a bis propionic acid, a dihydric alcohol chain extender and a catalyst - dibutyl tin laurate, and is diluted by acrylic ester; temperature reduction and emulsion are performed on the mixture after reaction; chain extension reaction is performed in water by a multi-amine chain extender, and siloxane modified polyurethane dispersoid which contains acrylic ester monomer is prepared; and an initiator - potassium persulphate is added into the siloxane modified polyurethane dispersoid for emulsion polymerization.

特征是先将大分子二元醇与二端羟丁基聚二甲基硅氧烷的混合液脱水后加入二异氰酸酯,反应后加入二羟甲基丙酸、二元醇扩链剂和催化剂二月桂酸二丁基锡,并用丙烯酸酯进行稀释,反应后降温乳化,用多元胺扩链剂在水中进行扩链反应,得到含有丙烯酸酯单体的硅氧烷改性聚氨酯分散体,然后再通过加入引发剂过硫酸钾进行乳液聚合。

Neighbor-Joining analyses of teleost hepcidins showed that the eelpout 4cys variant arose independently from the notothenioid version, which lends support to adaptive evolution of reduced cysteine hepcidin variants on cold selection. The NJ tree also showed taxonomic-specific expansions of hepcidin variants, indicating that duplication and diversification of hepcidin genes play important roles in evolutionary response to diverse ecological conditions.

另外我们在另一种生活于南极水域的eelpout中也发现了一种含有4个半胱氨酸残基的hepcidin,而eelpout和南极鱼notothenioid在分类学上分属于不同亚目,是一类相差较远的物种,利用Neighbor-Joining方法建树分析发现eelpout的hepcidin虽然同样仅含有4个半胱氨酸残基,但和notothenioid的4cys_hepcidin有着不同的起源,这也进一步说明了hepcidin中半胱氨酸残基数目的减少确实是对寒冷环境的一种适应性进化。

These mutations greatly changed the level of protein synthesis, lipogenesis and JAK2 phosphorylation stimulated by GH, although they did not affect the expression of the GHR and ligand binding.

研究结果表明豚鼠GHR中的一些氨基酸残基的取代并不影响生长激素通过它而诱导的细胞事件,而另外一些氨基酸残基的取代,例如168位的酪氨酸和332位的丝氨酸分别用在其它种属GHR中高度保守的精氨酸和酪氨酸的取代后,则明显地影响着豚鼠GHR介导的GH诱导的生理效应。

ABSTRACT Immobilized penicillin acylase (from E.coli) was used to catalyze 7 phenylacetamido 3 E propenyl cephalosporanic acid hydrolyzation into 7 amino 3 E propenyl cephalosporanic acid. Then, trans APRA was acylated with hydroxyethyl ester of 4 hydroxy D phenylglycine to obtain trans cefprozil.

以7 苯乙酰氨基 3 E 丙烯基 3 头孢菌素 4 羧酸为原料,在青霉素酰化酶作用下,首先酶法水解得到3 E 丙烯基 3 头孢菌素 4 羧酸,过滤固相酶,滤液调pH分离得到反式APRA固体;在青霉素酰化酶作用下,反式APRA再与对羟基苯甘氨酸乙二醇酯缩合,得到反式头孢丙烯;酶法合成所得的产品与进口反式头孢丙烯对照品一致。

Gemini surfactant, sodium oleoylamidodiphenyl ether disulfonate was synthesized from p-nitrodiphenylether,oleoyl choride and chlorosulphonic acid through nitro-group reduction,acylation and sulphonation.

以对硝基二苯醚、油酸酰氯、氯磺酸为主要原料,通过硝基还原反应、胺基酰化反应、磺化反应,合成了双子表面活性剂油酸酰胺基二苯醚双磺酸钠;并用IR,1HNMR,MS对产品及中间体结构进行了表征。

RESULTS: Sixteen compounds, ursolic acid (1), indole-3-carboxaldehyde (2), indole-3-carboxylic acid (3), p-coumaric acid (4), azelaic acid (5), N-trans-feruloyl tyramine (6), blumenol A (7), 2-hydroxy-3-methylanthraquinone (8), rubiadin l-methyl ether (9), rubiadin (10), quercetin (11), luteolin (12), chrysoeriol 6-C-β-boivinopyranosyl-7-O-β-glucopyranoside (13), alternanthin (14), stigmasta-5, 22-dien-3β-ol (15), and α-spinasterol (16) were obtained from the EtOAc extract of Alternanthera philoxeroides.

结果:得到并鉴定了16个化合物,分别为乌苏酸(1)、吲哚-3-甲醛(2)、吲哚-3-甲酸(3)、对-香豆酸(4)、壬二酸(5)、N-反式阿魏酰基酪胺(6)、布卢姆醇A(7)、2-羟基-3-甲基蒽醌(8)、甲基异茜草素-1-甲醚(9)、甲基异茜草素(10)、槲皮素(11)、木犀草素(12)、柯伊利素-6-C-β-波伊文糖基-7-O-β-吡喃葡萄糖苷(13)、莲子草素(14)、豆甾醇(15)和α-菠甾醇(16)。

They were two new compounds, [cyclo(Pro-Val-Phe-Phe-Pro-Val-Phe-Ser-Leu),7],[2-N-(1-methoxycarbonylethyl)guanosine, 10], and eight known compounds,(p-hydroxybenzoic acid, 1),(methyl succinate, 2),(russulaceramide, 3),(phenylalanine, 4),(guanine, 5),(β-carboline, 6),(uridine, 8), and (adenosine, 9). All the compounds were isolated from Amanita exitialis for the first time.

分别为:对羟基苯甲酸(p-hydroxybenzoic acid,1)、丁二酸二甲酯(methyl succinate,2)、神经酰胺(russulaceramide,3)、苯丙氨酸(phenylalanine,4)、鸟嘌呤核苷(guanine,5)、β-咔啉(β-carboline,6)、环(脯氨酸-缬氨酸-苯丙氨酸-苯丙氨酸-脯氨酸-缬氨酸-苯丙氨酸-丝氨酸-亮氨酸) [cyclo(Pro-Val-Phe-Phe-Pro-Val-Phe-Ser-Leu),7]、尿嘧啶核苷(uridine,8)、腺嘌呤核苷(adenosine,9)、2-N-(1-甲氧羰基乙基)鸟苷[2-N-(1-Methoxycarbonylethyl)guanosine, 10]。10个化合物均为首次从致命鹅膏中分离得到,其中化合物7和10为新化合物。

A base-catalyzed novel olefination methodology based on elimination of p-toluenesulfonamide:Treatment of diethyl cyanomethylphosphonate with catalytic amount of basegave the corresponding phosphoryl-stabilized carbanion, which added to the carbon-nitrogen double bond of N-tosyl imines.

新形成的氮负离子进一步攫取另一分子膦酸酯的活泼亚甲基氢形成加成产物同时再生出膦酰基稳定的碳负离子。加成产物消除对甲苯磺酰胺,高度立体选择性地得到-α-氰基-β-芳基-乙烯基膦酸二乙酯。

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