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TyPe II collagen induced arthritisln the rat ank1e joint andoVathumin as antigen induced arthritis WA in the rabbit knee joint wereestab1ish2 Qualitative evaluation of me in skin, muscle, synovium, cedilagearound joint and blood was performed by OMA3 The CIA rats were treated on day 7 after hind paw swelling and erythemaAnimals were injected intravenously with ase at a dose of 10mg/kg,tWenty minuots 1ater, one ankle of the rats random1y assigned was exPosedlaser irradiation at l00J/cm fOr l000 seconds, and another ankle wasM grouP wihout laser The other two groups is unmanipulatedcontrol group and untreated CIA group Bimaleolar ankle widthmeasuremellts were taken in all animals every tWo days using amicrometer The histopathology of the ank1e Joint was assessed at day 21after disease onset4 The pro1iferating cell nuclear antigen WCNA of CIA treated by PDT andthe HMME group without laser was doterdrined by immunohistochemiStry5 The AfA rabbits were treated on day 7 after knee swelling and erythemaThe theraPy invo1ved lntravenous injection of l0mg/kg HMME, fOl1owedby 20 minues period in dim light, and transdermal light treatment with\l00 J/cm2 fOr l000 seconds The inner sides of the treated Anees wereirradiated at first, and then the outer side did 24 hours later, the synovialtissue of the Anees joint were removed and in situ cel1 aPoptosis wasdetCCted With tednal deoxync1eotidyl transferase-mediated dUTP nickend labelingR6suIt8:l The pathologic changes of CIA and AIA include subsynovial inflammation,opovial hyPerplasia, pannus formation, cartilage and bone destructionresemble RA.2 The studies demonstrated that there are different uptake of HMME withinskin, muscle, synovium, cartilage and b1ood, and the synovium cou1draPidly uPtake more ase than skin and cartilage at the firSt 30 minuesaller intravenous injection of HMME3 The bimaleolar anke width had no different among PDT treated group,H group withollt 1aser and untreated CIA group But hlstologicalevaluation showed statiStical1y significallt reductions in synovialhyperplasia, pannus formation and cart1lage reosion, bone destruction andtotal score in PDT treated group4 Image analysis showed that the ratlo bforeen the areas of the coufltedobect to that of the entire area in PDTtreated grOup is lower than that in conirol group, but the integrated oPticaldensity had no different between the two groups5 Imape analysis showed that the ratio between the area of the countedobject to that of the e

治疗组在大鼠出现踝关节红肿后1周,炎症达到高峰时进行PDT治疗。随机治疗大鼠一侧的踝关节,另。2。一一侧作单纯HMME 对照。治疗方法是大鼠麻醉后尾静脉注入 HMME10ngkg,20分钟后踝关节照光,激光波长627.sum,功率密度 100mwcm',照射时间1000秒,能量密度100)/。治疗后避光喂养72 小时。隔日一次测量大鼠的踝关节左右横径,治疗后两周取关节进行病理d 观察。 4。大鼠CIA模型用上述方法进行PDT治疗后,治疗组和单纯HMME 组用兔疫组化SP法检测石蜡切片的核增殖抗原。 5。兔AIA模型在关节炎出现第七天进行PDT治疗,随机治疗一侧膝关节,另一侧作自身对照。兔耳静脉注入I'arrainrelomg/Kg,20分钟后,膝关节用金蒸气激光照射,激光能量密度100)儿旷。24 /J'时后取膝关节滑膜作病理检查,并用脱氧核昔酸末端转移酶介导的缺口末端标记法原位检测凋亡细胞。结果: 1。模型观察:CIA大鼠炎症高峰期滑膜下炎细胞浸润明显,滑膜细胞明显增殖,炎症达到高峰后二周,血管缀形成,并侵蚀和破坏软骨和骨, CIA模型病理改变与人类RA相似。兔AIA模型膝关节滑膜病理可见滑膜细胞增生,滑膜下炎细胞浸润,也与人类RA滑膜改变相似。 2。关节周围组织中光敏剂含量的测定结果表明,各组织对HMME 的吸收速度和吸收量不同,荧光值一时间曲线不同,滑膜组织比皮肤和软骨对 HMME的吸收多,在 2 0分钟时即有明显差异。 3.PDT对CIA模型的治疗结果表明:PDT治疗后关节炎组、单纯 HMME组和治疗组踝关节左右横径统计学检验差异没有显著性,但病理评分PDT治疗组滑膜增生、血管资形成及软骨破坏、骨破坏和总分比关节炎对照组和HMME对照组好,统计学检验差异有显著性。。3_军医进修学院硕士学位论文中文摘要 4.PDT治疗组PCNA阳性细胞较对照组少,图像分析结果表明面密度(阳性染色的面积总和与统计视野面积的比值)治疗组小于对照组,统计学检验差异有显著性。。 5.PDT治疗组凋亡阳性细胞较对照组明显增多,图像分析结果单位视野内阳性细胞数和面密度PDT治疗组高于对照组,统计学检验差异有显著性。凋亡细胞核直径PDT治疗组较小,与对照组相比,统计学检验差异有显著性。结论:二。CIA、AIA的病理改变类似人类RA,可作为研究RA病因、发病机制、检查及治疗方法的模型。 2。各组织对HMME的吸收速度和吸收量不同,滑膜组织比皮。

PGL could effectively degrade the pectic acid in the DCS of Masson pine BCTMP and bleached DIP,resulting in a decrease of about 40 percent in CD value.

PGL可以有效地降解脱墨浆和马尾松漂白化机浆DCS中的果胶酸,DCS的CD值下降了约40%。

The peracetic acid can be used in the disinfection of thermolabile packaging material in the production process.

结论经过氧乙酸灭菌的塑料瓶能达到无菌要求,酸的残留量对ph值的影响不显著,生产上可用过氧乙酸灭菌法对不耐热的内包材进行灭菌。

Mm, 5 μm and a UV detector. Elution was performed at a flow rate of 1 mL/min, with a gradient of methanol-acetonitrile-water starting at 80∶10∶10, increasing linearly to 86∶10∶4 in 35 min, then returning to the initial conditions in 5 min. Elution of phenacyl esters was monitored by absorbance at 254 nm. Pentadecanoic acid was used to be an internal standard.

分析所用色谱柱为ZORBAXSB C18柱,以十七酸作为内标,甲醇-乙腈-水为流动相,采用梯度洗脱(梯度洗脱程序为甲醇-乙腈-水由80∶10∶10在35 min内线性变化到86∶10∶4,然后在5 min内恢复到起始比例,流动相流速为1 mL/min),通过测定苯乙酰甲酯在254 nm处的吸光度值来测定脂肪酸含量。

Signal multiplier spectrophotometry was used for the determination of baicalin, clorogenic acid, phillyrin and pH variation when shuanghuanglian with 5 kinds of intravenous solution and penicillin injection was mixed.

本实验应用系数倍率法测定双黄连粉针与5种输液及青霉素配伍时黄芩苷、绿原酸、连翘苷的含量,并考察pH值变化。

This research studied the optimal strain combination through single strain and mixed strains fermentation from Sweet Sorghum juice. The suitable proportion and quantity of inoculation, the optimum nitrogen source and its ratio in the medium were established through mixed fermentation. The optimum pH values, fermentation time and temperature were obtained by L9 (3)3 orthogonal experiment. The optimum mixture of biotechnology fulvic acid, Azotobacter chooroccum, Phospho bacteria and Silicate bacteria were studied.

本文以甜高粱秸秆汁为原料,通过单菌及混合菌种发酵实验确定了发酵的最佳菌种组合;利用微生物混合发酵确定了发酵菌种的接种比例、接种量、最佳氮源及其添加量;用L_9(3)~3正交设计的方法,确定了发酵的最佳pH值、发酵时间和发酵温度;研究了生化黄腐酸液体肥料和圆褐固氮菌、钾细菌、磷细菌的复配工艺,并在作物上进行了田间试验。

The hydroxide value and viscidity of lignin-based polyhydric alcohol are 450~550mgKOH/g and 500~1000mPa.s respectively while 20 parts lignosulfonate calcium dissolves in common polyhydric alcohol for 2 hours.

4在160~170℃,20份木质素磺酸钙与GR-4110G多元醇互溶2小时得到羟值为450~550mgKOH/g、粘度在500~1000mPa.s的木质素多元醇。

The accurate analysis of the uranium content in the reference materials is based on the potentiometric titration method.

采用以基准物质重铬酸钾为滴定剂的自动电位滴定法对基准物质中的铀含量进行准确定值。

Objective:(1) To compare the sensitivity, specificity, and positive prognosticative value in the diagnosis of rheumatoid arthritis by examining antifilaggrin antibody, anti-cyclic citrullinated peptide antibody and rheumatoid factor respectively simultaneously.

目的:①检测类风湿关节炎病人血清抗聚角蛋白微丝蛋白抗体、抗环瓜氨酸肽抗体及类风湿因子,比较单独检测和联合检测对RA诊断的敏感性、特异性、阳性预测值。

Conclusionph and the quality of danshensu,protocatechuic aldehyde and salvianolic acid b is stable.

结论配伍液中丹参素、原儿茶醛、丹酚酸b的质量和ph值基本稳定。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

聚光:照片上是建在西班牙桑路卡拉马尤城的一座新型PS20塔式太阳能电站。被称为&日光反射装置&的镜子将太阳光反射到主塔,然后用聚集的热量产生蒸汽进而通过涡轮机转化为电力