酶蛋白

In this review, we discussed the consequences of inhibiting histone deacetylases in cycling versus non-cycling cells, in light of the dynamics of histone acetylation patterns with a specific emphasis on heterochromatic regions of the genome.

本综述通过讨论HDACIs对周期和非周期细胞中组蛋白去乙酰化酶的抑制结果，来阐明组蛋白乙酰化模式的动力学特征，特别是对基因组异染色质的作用。

There are 11 gene bindings disappear in the normal group, but appear in the model group, and then disappear in the treat group, that indicates the 11 gene bindings are correlated with the epilepsy and Caohuozhimutang. After searching in the Gene Bank, 7 bindings in the 11 gene bindings are homogenic with the 8q31 ribosomal protein gene, 15p12 paraneoplastic neuronal antigen gene, 4q22 diacylglycerol kinase iota gene, xq37 FMR2 protein and 11p11 roudabout homolog 1, and 4 bindings of which are novel gene.

经NCBI美国国家基因库检索，这11条基因中的7条已知基因分别与位于鼠染色体8q31位置的核糖体蛋白、15p12位置的周围肿瘤神经元的抗原(paraneoplastic neuronal antigen)、4p22位置的甘油二酯酶、xq37位置的FMR2蛋白（FMR2 protein）的基因以及以及位于果蝇染色体11p11位置的交叉同族体（roundabout homolog 1）有极高的同源性；有4条基因片段同源性较低，为功能未知的新基因，已经在GeneBank进行了注册，注册号分别CK325391、CK325392、CK325393、CK325394。

This binding mode is different from those observed in the crystal structure of complexes formed by a histone deacetylase-like protein with trichostatin A or suberoylanilide hydroxamic acid.

这种结合方式与已经阐明的组蛋白去乙酰酶类似蛋白与曲古柳菌素A(trichostatin A，TSA)和suberoylanilide hydroxamic acid形成的复合物晶体结构中配体与酶的作用方式完全不同。

In Picomaviridae, 3D protein was RNA dependent RNA polymerase, and had been applied indifferential diagnosis of FMDV infection, and other picornaviruses.

在PTV病毒中，3D蛋白是具有RNA依赖RNA聚合酶(RNA dependent RNA polymerase，RDRP)活性蛋白，能介导机体产生特异性的抗体。

AIM In order to search inhibitors of protein kinase CK2, we observed the inhibitory effects of kaempferol on recombinant human protein kinase CK2 holoenzyme and its kinetics in vitro.

目的为了筛选蛋白激酶CK2的抑制剂，观察山萘黄素对重组人蛋白激酶CK2的抑制效果及其酶动力学机制。

Studies of the binding of metal to calmodulin and the subsequent binding of metal-calmodulin complexes to the target protein/peptide revealed that the La-content calmodulin complexes to its target exhibit similar affinity with the Ca-calmodulin complexes.However, there were substle differences in protein conformation as well as the kinetical properties between the two kinds of metal-calmodulin complexes, suggesting Ln could produce cellular effects via the Ca/calmodulin signaling systems.

稀土离子和钙调蛋白的结合以及后续和靶酶的结合，在热力学上与钙离子激活蛋白具有相同的亲合力，但在动力学性质上以及细微构象上明显不同，显示稀土离子可通过细胞钙相关信号系统产生特别的生物效应。

Through PCR and sequencing, a fragement sequence with lamin gene feature was obtained. It was of of transcriptional activity. In addition, we also cloned and identified giardial DNA topoisomerase gene.Our phylogenetic analysis showed that although Giardia diverged early but not first, thus, it is not as primitive as thought before.

然后进行了核纤层蛋白基因的扩增和鉴定，获得了一个具有明显核纤层蛋白基因特征的基因序列片段，并证明它是表达的且不具内含子；此外还克隆鉴定了作为核骨架重要成分的DNA拓扑异构酶II的基因；在此基础上结合已报导的不同进化地位生物上的数据进行了分子系统学分析，结果显示贾第虫虽然分支较早，但不象过去所认为的那么原始。

Methods: Thirty adult male Wistar rats were randomly divided into three groups: the operation group, the transplantation of MSCs group and the injection of saline group. Functional outcome measurements were performed based on the modified neurological severity score at day 1, 7, 14, 21 and 28 after MACO. The survival, migration, expression of Nestin, glial fibriliary acidic protein and neuronspecific enolase of 5bromo2deoxyuridinelabeled MSCs were detected by immunohistochemical double staining.

线栓法建立左侧大鼠MCAO模型，随机分为3组：手术组、MSCs 移植组、生理盐水组。5溴2脱氧尿核苷标记的MSCs移植后，采用改良神经功能损伤评分系统评价大鼠神经功能恢复情况；应用免疫组织化学双染技术检测MSCs的存活、迁移及其巢蛋白、胶质纤维酸性蛋白和神经元特异性烯醇化酶的表达。

Objective To investigate the change of urinary microdose protein in neonates with hyperbilirubinemia.

目的 探讨不同程度黄疸新生儿尿视黄醇结合蛋白、尿N 乙酰β D氨基葡萄糖苷酶、微量白蛋白的变化。

In this dissertation, serial researches have been carried out concerning the processing of wheat germ protein by micronization and alkali extraction, the preparation and the action mechanism of antioxidant hydrolysates from wheat germ proteins.

本论文以脱脂麦胚为原料，对麦胚蛋白在稀碱和微细化处理条件下的提取工艺进行研究，并对麦胚蛋白的酶解工艺、抗氧化活性及作用机理进行研究，主要研究内容及结果如下：1。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。