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In young human umbilical vein endothelial cells, human aortic endothelial cells, and human coronary artery endothelial cells, miR-217 induces a premature senescence-like phenotype and leads to an impairment in angiogenesis via inhibition of SirT1 and modulation of FoxO1 (forkhead box O1) and endothelial nitric oxide synthase acetylation.

在婴儿脐静脉内皮细胞、人类主动脉内皮细胞以及冠状动脉内皮细胞中,miR-217可以诱导这些细胞出现一种早衰样表型,进而通过抑制SirT1的表达、调控Fox01以及内皮细胞一氧化氮合酶的乙酰化来损伤新生血管的形成。

Understand and familiarize with the classification of cholinergic agents, M effects, N effects, and also the pharmacological effects, clinical application and adverse reaction of physostigmine.

熟悉拟胆碱药的分类、M、N样作用、毒扁豆碱的作用、应用及主要不良反应;有机磷酸酯类中毒解救原则、胆碱酯酶复活药碘解磷定的作用机制和临床用途。

BMSCs expressing Ad-GFP had three types of subpopulation structures under a fluorescence microscope; when the virus titer was ≥ 1×10^6 PFU/mL, BMSCs proliferation was suppressed at the early stage, in a dose-dependent manner.

荧光显微镜下可见表达Ad—GFP的BMSCs有三种亚群结构:滴度≥1 10^6PFU/mL时,BMSCs增殖在早期受到抑制,且呈剂量依赖;转染Ad—GFP的BMSCs经β一巯基乙醇诱导可分化为神经元样细胞,神经元特异性烯醇化酶阳性。

Objective To explore the feasibility of automatically detecting antibody to Treponema pallidum by using modified traditional PPA method.

目的探讨利用RSP 200加样仪及Spectra酶标仪将传统手工操作的TPPA改良为一种简易的自动化检测技术的可行性。

Objective To explore the feasibility of automatically detecting antibody to Treponema pallidum by using modified tra-ditional PPA method.

目的 探讨利用RSP200加样仪及Spectra酶标仪将传统手工操作的TPPA改良为一种简易的自动化检测技术的可行性。

In order to establish a quick and reliable identification system for the main Citrus viruses, total RNA was isolated from the sampled trees showing typical symptoms of Citrus tristeza virus, Citrus exocortis viroid and Citrus tatter leaf virus for RT-PCR analysis.

为建立主要柑橘病毒病准确、快速的分子检测体系,在表现柑橘衰退病、柑橘裂皮病和柑橘碎叶病典型症状的病树上采叶样提取总RNA进行反转录聚合酶链式反应分析。

Results Microscopically, different degrees of hepatocytic degenerative changes and hyperplasic fibrous tissue and typical false lobule formation could be seen. Timm's staining result showed uneven distributed black granular deposits in the hepatocytes. No specific PAS staining was observed. Utrastructurally, the mitochondria were increased in volume and dramatically different in shape. The number of lysomes were increased.

结果 光镜下肝细胞表现为不同程度的退行性变,胶原纤维增生以及典型假小叶形成;Timm's染色阳性,发现不均匀分布黑色颗粒或团块样物质沉积;PAS染色则普遍缺乏特异性染色;超微结构显示线粒体形态多样,体积增大,溶酶体增多,粗面内质网管腔扩张,附着核糖体的脱颗粒,以及胞质水肿,质膜溶解。

Our study showed that about 3% mononucleated cells of human peripheral blood could be induced to osteoclast-like cells which have the ability of bone resorption and show TRAP-positive when coculture with UMR106 in the presence of 1,25 dihydroxyvitamin D3, macrophage-colony stimulating factor and dexamethasone.

在1,25_2D_3、地塞米松和M-CSF存在下,人外周血单个核细胞与UMR106细胞共培养,约3%的单个核细胞可被诱导成为具有骨吸收能力且抗酒石酸酸性磷酸酶染色阳性的破骨细胞样细胞。

To elucidate the effect of p -nonylphenol on cytochrome P450 aromatase (P450arom) gene and Mullerian inhibiting substance gene in fish gonad, exploring the mechanism of its estrogenic action.

研究壬基酚(P—nonylphenol,NP)对细胞色素P450芳香化酶基因(P450arom)和苗勒氏管抑制物基因表达的影响,探索其对鱼类雌激素样作用的分子机制。

At the end of the culture, PBMCs cultured on coverslips were fixed and stained for tartrate resistant acid phosphatase, a marker of osteoclast.

对培养终末细胞作组织化学染色,检测破骨细胞特征性标志物抗酒石酸磷酸酶的表达;并以象牙磨片上虫蚀样骨吸收陷窝的形成为指标检测其生物学活性。

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Finally, according to market conditions and market products this article paper analyzes the trends in the development of camera technology, and designs a color night vision camera.

最后根据市场情况和市面上产品的情况分析了摄像机技术的发展趋势,并设计了一款彩色夜视摄像机。

Only person height weeds and the fierce looks stone idles were there.

只有半人深的荒草和龇牙咧嘴的神像。

This dramatic range, steeper than the Himalayas, is the upturned rim of the eastern edge of Tibet, a plateau that has risen to 5 km in response to the slow but un stoppable collision of India with Asia that began about 55 million years ago and which continues unabated today.

这一引人注目的地域范围,比喜马拉雅山更加陡峭,是处于西藏东部边缘的朝上翻的边框地带。响应启始于约5500万年前的、缓慢的但却不可阻挡的印度与亚洲地壳板块碰撞,高原已上升至五千米,这种碰撞持续至今,毫无衰退。