酰胺化

The optimum reaction conditions are as follows: diphenylmethanethiol : methyl chloroacetate is 1:1.5, and the reaction carried out at 100℃ for 4 h, 2- acetamide can be carried out in the room temperature for 20 h, the yield of 2- acetamide was 76%, hydrogen dioxide: 2- acetamide is 1:1, and the reaction carried out at 60℃ for 3 h, the yield of modafinil was 79%, the total yield of reaction can be reached 48%.

研究表明，采用氯乙酸甲酯作为醚化试剂，反应时间4h，反应温度100℃，二苯甲硫醇：氯乙酸甲酯=1：1.5，室温下氨解反应20h，二苯甲硫乙酰胺收率76%；采用过氧化氢作为氧化试剂，反应时间3h，反应温度60℃，过氧化氢：二苯甲硫乙酰胺=1：l，莫达非尼收率79%，反应总收率可达48%。

In some cases, its epimer 4 was also obtained. 22 compounds were synthesized, among them 18 were new.3. Using the intramolecular Pictet-Spengler reaction to form the pentacyclic skeleton of Et-743, the byproducts 25 were obtained under various conditions. The structures of them were determined to be 1, 2-dihydro-isoquinoline compounds, and the mechanism of the reaction was proposed.B. The synthesis of the analogs of Et-743Because of the failure of removing the protective groups in compounds 14, the synthetic strategy was adjusted.

对于苄基保护的羟基化合物13a，顺利得到化合物30，然后与不同的羧酸反应得到18个酯化合物33-50；对于苄氧羰基保护的氨基化合物13b，由于脱除保护基的化合物31在空气中不稳定，所以我们采取不经分离纯化，直接与羧酸反应得到酰胺化合物53-62，然后再分别对其C-21位的羰基进行还原氰基化，得到10个酰胺目标化合物63-72，另外，我们还对羟基转化为氨基的反应进行了探索。3。

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By using the a device being similar to water segregator and by controlling the temperature, cyclization of the intermediate product in chloroform reduced carbonization and gave 2-dodecaneanthraquinane in 68.1% yielding.

以十二烷基苯和苯酐为起始原料，经酰基化、关环和磺化三步反应合成了3-十二烷基蒽醌磺酸；并进一步改进和优化了合成工艺条件：即在催化剂三氯化铝过量50%并有三乙胺存在的条件下，中间体2-（4-十二烷基苯甲酰基）苯甲酸收率为72.45%；关环反应采用氯仿作溶剂，利用类似分水器的装置有效控制反应温度以减少碳化，2-十二烷基蒽醌的收率为68.1%。

Chiral homoallylic alcohol was prepared in this paper from asymmetric allylation of aldehyde with enantiomerically pure allylboronate tartramides such as chiral N,N'-diphenyl tartramide and N,N'-di...

本文以手性烯硼酸丙基酒石酸酰胺酯(如烯丙基硼酸-N，N'-二苯基酒石酸酰胺酯)为辅基，进行醛的不对称烯丙基化反应研究。

The weak interaction could not be ignored, which was suggested to be significant in preventing the tautomerization of FM, especially when the concentration of FM increased in the aqueous solution of FM.

在作者早期的研究中发现，此相互作用对于阻碍甲酰胺的异构化具有重要意义，特别是当甲酰胺在溶液中含量增大时，此相互作用更加不能忽视。

Copolymerize methacrylic acid 3(4′-N,N-dimethylamino) ketone xanthate and acrylamide were copolymerized with N,N-methylene bisacrylamide,and then combined with silane ethylene group in the form of covalent bond on the quartz glass shee t to be made into a sensor,to determine ethanol.

将甲基丙烯酸3-(4′-N，N-二甲氨基)黄酮酯和丙烯酰胺、N，N′-亚甲基双丙烯酰胺共聚并共价键合在硅烷化的含乙烯基团的石英玻片上，制成了可测定乙醇的传感器。

To our surprise, when the amount of iodide was added to 1:1 ratio with samarium, another different reaction occurred to give the iodination product (2Z)-2-alk-2-enoates in high yields.

同样地，结构类似的三氯乙醇酰胺的酯在二碘化钐的促进下也发生了类似的还原消除反应，以高产率得到N-(2，2-二氯乙烯)酰胺，该方法特色是条件温和，反应迅速。

Starting from tetrafuran, 2_(4_Aminosulfonylphenyl)_4H_1,2_thiazine_1_dioxide, an antiepileptic drug with special structure, was obtained via esterification, sulphonation, chloridization, condensation and cyclization.

以四氢呋喃为原料，经酯化、磺化、酰氯化、缩合、环化等步骤，合成了化学名为 4_(四氢_2H_1，2_噻嗪基_2 )苯磺酰胺_S_S_二氧化物的抗癫痫药舒噻嗪，通过IR、1HNMR和元素分析对其结构进行了表

Synthesis of the antiepileptic tiagabine hydrochloride;2. Starting from tetrafuran, 2_(4_Aminosulfonylphenyl)_4H_1,2_thiazine_1_dioxide, an antiepileptic drug with special structure, was obtained via esterification, sulphonation, chloridization, condensation and cyclization.

以四氢呋喃为原料，经酯化、磺化、酰氯化、缩合、环化等步骤，合成了化学名为 4_(四氢_2H_1，2_噻嗪基_2 )苯磺酰胺_S_S_二氧化物的抗癫痫药舒噻嗪，通过IR、1HNMR和元素分析对其结构进行了表

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐