酰胺

Results Nicotinamide at 1-5 mg/ml induced apoptosis of GLC-82 cells in a dose-dependent manner, and group 4 mg/ml and group 5 mg/ml showed increased apoptosis than other groups. Distinct morphologic changes of cell apoptosis such as karyopyknosis and conglomeration were observed; Cell migration became slower as the dosage of Nicotinamide increased;Cells produced an arrested at G1 phase, accompanied by a reduction of cells transiting through S phase.

结果 烟酰胺诱导细胞凋亡程度与用药剂量呈正相关，较高剂量的药物能引起GLC-82肺腺癌细胞呈现边界不清，体积缩小，核固缩，染色质凝集、边缘化，甚至细胞发生破碎，凋亡小体形成；随着烟酰胺浓度的增高GLC-82细胞向划痕区的愈合速度不断减慢；烟酰胺的浓度大于等于3 mg/ml 时，细胞周期主要表现为G1 期比例的上升伴随S期比例的下降。

Results: The extract of propolis had certain antineoplasm effect and the inhibition rate of propolis extract on tumor is 27.74％ and when combined with cyclophosphamide, the inhibition rate reached to 50.32％, even antagonized leucocytopenia caused by cyclophosphamide.

结果：蜂胶提取物的抑瘤率为27.74％，与环磷酰胺合用的抑瘤率为50.32％，比单用蜂胶提取物及环磷酰胺分别提高22.58％和9.03％(P＜0.05)，并能减轻环磷酰胺所致的骨髓造血功能抑制，使血液白细胞维持在正常水平(P＜0.01)。

AM - NaAMPS - DEAM terpolymer was synthesized from acrylamide, Sodium - 2 - acrylamido - 2 - methylpropane sulfonate and N,N - diethylacrylamide by free radical initiation copolymerization in aqueous solution.

以丙烯酰胺，2－丙烯酰胺－2－甲基丙碳酸钠，N，N－二乙基丙烯酰胺为单体，通过在水溶液中自由基引发共聚合，合成出了AM－NaAMPS－DEAM三元共聚物。

The structure analysis indicates that the reverse symmetry ligand H4LB molecules are linked into a 2D supermolecular network by two types of hydrogen bonds. One type occurs between the oxalamide oxygen group and the phenol hydroxyl qroup of the nearest molecule with d=2.906(2) and ∠O-H…O=151.8°. The other type is between the oxalamide nitrogen group and the oxalamide oxygen group of anther molecule with d=2.849(2),∠N-H…O=158.7°.

晶体结构研究表明配体H4L为顺式桥联分子，晶体中存在两种氢键，一种是草酰胺基团的O原子与苯环上的酚羟基形成O-H…O氢键[d=2.906(2)，∠O-H…O=151.8°]；另一种是草酰胺基团的氨基与相邻草酰胺基上的O原子形成N-H…O氢键[d=2.849(2)，∠N-H…O=158.7°]，通过上述两种氢键将化合物H4LB连接成二维网络结构。

Finally, the cytotoxic and antibacterial activities of the oxamido-bridged binuclear complexes were studied in vitro.. This dissertation consists of three sections as follows:1. The crystal structure of a oxamide dinitrate,(1) [H_4dmaeoxd](NO_3)_2 H_2dmaeoxd = N,N\'-bis[2-ethyloxamide, has been obtained. The diversity of complexes with different structures is carried out by successful synthetic strategy of controlling species of metal ions, counter anions, pH values and solvents in the course of synthesis. Four dinuclear complexes bridged by trans-dmaeoxd2-: [Cu_2_2](ClO_4)_2 (2), [Cu_2_2](ClO_4)_2 (3),、[Cu_2(Me_2phen)_2](ClO_4)_2 (4), [Cu_2_2(H_2O)_2] (5); Four dinuclear complexes bridged by cis-dmaeoxd2-: [NiNi_2](ClO_4)_2 (6), [CuNi_2](ClO_4)_2·2CH_3OH (7), [CuZn_2]-(ClO_4)_2·2H_2O (8), [Cu(H_2O)Ni_2](ClO_4)_2.0.5CH_3OH (9); three 1-D polynuclear complexes: [Cu_2]_n·nH_2O (10), [Cu_2(H_2O)_2-]_n·4nH_2O (11), [Cu_2(H_2O)]_n(NO_3)_n·2nH_2O (12); one 2-D polynuclear complex,[Cu_6_3(μ_3-OH)_2(H_2O)_2]_n(ClO_4)_(4n).2nH_2O (13); the others: [VO(H_2O)]·2H_2O (14), [Zn_2_4](ClO_4)_2·H_2O (15), [Cu_2]·2DCM (16) have been synthesized and characterized by X-ray single crystal diffraction, elemental analysis, IR spectra.

本论文主要包括以下三部分：一、合成得到了一个草酰胺配体硝酸盐的单晶结构，[H_4dmaeoxd](NO_3)_2 (1)；通过调控金属离子的种类、端基配体、抗衡阴离子、溶剂、pH值等条件定向合成了四个反式草酰胺桥联双核铜配合物：[Cu_2_2](ClO_4)_2 (2)、[Cu_2_2](ClO_4)_2 (3)、、[Cu_2(Me_2phen)_2](ClO_4)_2 (4)、[Cu_2_2(H_2O)_2] (5)；四个顺式草酰胺桥联同/异双核配合物：[NiNi_2](ClO_4)_2 (6)、[CuNi_2](ClO_4)_2·2CH_3OH (7)、[CuZn_2]-(ClO_4)_2·2H_2O (8)、[Cu(H_2O)Ni_2](ClO_4)_2.0.5CH_3OH (9)；三个一维聚合物： [Cu_2]_n·nH_2O (10)、[Cu_2(H_2O)_2-]_n·4nH_2O (11)、[Cu_2(H_2O)]_n(NO_3)_n·2nH_2O (12)；一个二维聚合物： [Cu_6_3(μ_3-OH)_2(H_2O)_2]_n(ClO_4)_(4n)。2nH_2O (13)；单核钒配合物[VO(H_2O)]·2H_2O (14)、草酸根桥联双核锌配合物[Zn_2_4](ClO_4)_2·H_2O (15)、美洛西康铜配合物[Cu_2]·2DCM (16)，利用元素分析、摩尔电导、红外光谱、电子光谱和单晶X-射线衍射对上述所得化合物进行了结构表征，探讨了结构影响因素，并研究了其超分子结构。

A novel fluorescent acrylamide monomer, N-(4-Benzooxazol-2-yl-phenyl)- acrylamide, was prepared from o-aminophenol, p-aminobenzoic acid and acryloyl chloride, with polyphosphoric acid as dehydrating agent and triethylamine as deacidification agent.

以邻氨基苯酚、对氨基苯甲酸和丙烯酰氯为原料，以多聚磷酸为脱水剂、三乙胺为脱酸剂，研制了一种新的荧光丙烯酰胺单体N-[4-（苯并噁唑-2-）苯基]丙烯酰胺。

PI-1 and PI-2 polyimide films were prepared from 3,3′,4,4′-benzophenone tetracarboxylic dianhydride and ODA确良by two-step polymerization under the thermal and mixed imidization procedures.

采用两步法首先合成聚酰胺酸，然后经热酰亚胺化和混合酰亚胺化工艺制备了BTDA/ODA型的PI-1 和PI-2两种聚酰亚胺薄膜。

Methods 4-Hydroxy- benzonitrile was treated with sodium hydrogen sulfide and anhydrous magnesium chloride in dimethyl formamide to give thioamide, which was then directly cyclized with ethyl 2-chloroacetoacetate without separation to give ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(2) in one-pot; then 2 was formylated with Duff reaction adopting hexamethylenetetramine in trifluoroacetic acid to give ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(3); finally, the target compound was obtained by the treatment of 3 with hydroxylamine hydrochloride and sodium formate in formic acid.

采用&一勺烩&方法，以4-羟基苯甲腈为起始原料，首先与硫氢化钠和无水氯化镁在N，N-二甲基甲酰胺中反应，所得中间体不经分离，直接加入2-氯乙酰乙酸乙酯进行环合反应，得到2-(4-羟基)苯基-4-甲基-5-噻唑甲酸乙酯（2）；然后通过六亚甲基四胺/三氟乙酸进行Duff反应，得到2-(3-甲酰基-4-羟基)苯基-4-甲基-5-噻唑甲酸乙酯（3）；再经盐酸羟胺/甲酸/甲酸钠体系脱水得到目标化合物。

N - Fmoc - L - B - homoglutamine and N - Fmoc - L - B - homoasparagine have been prepared by anidt - eistert synthesis from commercially available N - Fmoc - L - a - glutamine and Na - Fmoc - Nr - trityl - L -asparagine.

描述了应用Arndt-Eistert反应合成两种含酰胺基的N-Fmoc-L-β-氨基酸的方法，讨论了在Wolff重排过程中，N-Fmoc-L-α-谷氨酰胺重氮甲基酮和N-Fmoc-L-α-天冬酰胺重氮甲基酮的各自特点及反应过程中生成的副产物。

METHODS: Collaborative meta-analyses were undertaken of 194 unconfounded randomised trials of adjuvant chemotherapy or hormonal therapy that began by 1995. Many trials involved CMF (cyclophosphamide, methotrexate, fluorouracil), anthracycline-based combinations such as FAC (fluorouracil, doxorubicin, cyclophosphamide) or FEC (fluorouracil, epirubicin, cyclophosphamide), tamoxifen, or ovarian suppression: none involved taxanes, trastuzumab, raloxifene, or modern aromatase inhibitors.

对194个开始于1995年的关于辅助化疗或激素治疗的随机试验进行meta分析，许多试验包含了CMF(环磷酰胺、氨甲喋呤、氟尿嘧啶)，蒽环药物为基础的联合化疗比如FAC(氟尿嘧啶、阿霉素、环磷酰胺)或FEC（氟尿嘧啶、表阿霉素、环磷酰胺）及他莫昔芬或卵巢去势；无一包含紫杉烷类、赫赛汀、雷洛昔芬及芳香化酶抑制剂。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。