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Then Doripenem came into the market in the July ,2005. We studied the synthesis of Doripemen.Firstly, we synthesized the chemical 2 from the starting material------o-hydroxylphenylacylamine through Reformastky reaction, alkylation, Diekmann reaction, enolization, esterification and etc. Secondly, we synthesized the chemical 3 from L — hydroxylproline through the protection of carboxyl, amidogen and hydroxyl group, reduction by NaBr, SN_2 substitution and Mitsumobu reaction.

我们以水杨酰胺为起始原料,经Reformatsky反应、烷基化、Diekmann环合、烯醇化、酯化等反应合成双环母核2;再从L-羟基脯氨酸出发,经酯化保护羧基、保护氨基、保护羟基、硼氢化还原酯得醇、Sn2取代和Mitsumobu反应等合成巯基侧链3;最后由化合物3经脱保护、水解得硫醇,和化合物2在二异丙基乙基胺的作用下缩合,最后Pd/C催化脱保护,历经16步反应最终得到产物多尼培南。

Amino desacetoxycephalosporanic acid (7 - ADCA) is an ampholyte.

7-氨基去乙酰氧基头孢霉烷酸是两性化合物,从等电点两侧改变溶液的 p H值都可以产生过饱和度并结晶得到晶体产品,本文对 7-ADCA两种方法结晶的初级成核过程进行了研究。

The paper studied the effect of 5-aminolevulinic acid on chlorophyll a, photosynthetic rate and chlorophyll fluorescence dynamics of Anthurium andraeanum.

探讨叶面喷施5-氨基乙酰丙酸对红掌光合作用及叶绿素荧光参数的影响,为花卉植物上合理施用ALA奠定基础。

Any of a group of five chemically related nonmetallic elements including fluorine, chlorine, bromine, iodine, and astatine.

酰亚胺源自氨的一种化合物,含有与一个二价酸基或者二个一价的酸基结合的氨基

Synthesis of novel sulfonamide-prolinols and their application on the asymmetric addition of diethylzinc to benzaldehyde.

三、研究了脯氨酸衍生的新型手性磺酰胺-氨基醇的合成及其催化二乙基锌对苯甲醛的不对称加成反应 1。

The 50strains of detected strain show partial and plenitude resistance to β- lactamase tribe such as penicillin class, cef-operazone class ,show sensitive to amino- glucoside tribe buch as gentamycin, tobramycin, and quinolone tribe such as Ciprofloxacin, Nrfloxacin and Chloramphenicol.

结果〕经检测的50株菌株,显示对β-内酰胺族部分或完全耐药,对氨基糖苷族、酮诺喹族以及氯霉素等抗生素为敏感反应

Chitosan is obtained by N-deacetylation of chitin. It has a number of free amino group.

壳多糖是甲壳质脱乙酰基的产物,它含有大量的自由氨基。

Objective To evaluate relationship between urine NAG isoenzyme and acute cerebrovascular disease. Methods The activity of urine NAG isoenzyme, NAG/Cr and blood NAG isoenzyme in 47 patients with acute CVD (15 patients with brain hemorrhage and 32 patients with brain infarction) were examined by p-nitrobenzene chronometry.

目的 探讨尿液N-乙酰-β-D-氨基葡萄糖苷同工酶与急性脑血管病的关系方法采用对硝基酚比色法,分别测定了47例急性脑血管疾病患者(其中脑出血15例,脑梗死32例)的尿液NAG同工酶谱、尿NAG与尿肌酐的比值、血清NAG活力。

A new kind of copolyetherimide is synthesized, and effect of contents of this kind of COPEI resin on morphology of blends of COPEI/the diglycidyl ether of bisphenol A(the Epikote 828)/ 4,4'-diamino diphenyl sulphone and preparation of epoxy resin microspheres are researched .

采用共缩聚方法合成了一种新型聚醚酰亚胺,通过改变它在COPEI/双酚A二缩水甘油醚型环氧树脂(E828)/二氨基二苯基砜共混体系中的用量,考察了对共混体系的相结构以及对制备环氧树脂微球的影响。

Resins: gum dammar; PU dispersion; silicone resin, epoxy resin, alkyd, acrylic Resin, polyester resin, urethane resin, polyamide resin, amino hardener; two pack hydroxy acrylic, two pack isocyanate-free acrylic; vinyl chloride co-polymers, polyvinyl butyrals, thixotropic resin.

树脂类:达玛树脂;水性PU分散体;有机硅、环氧、醇酸、丙烯酸、聚酯、聚氨酯、聚酰胺、氨基固化剂;双组份羟基丙烯酸、双组份不含异氰酸脂丙烯酸;聚氯乙烯共聚物、聚乙烯醇缩丁醛、触变性树脂。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

聚光:照片上是建在西班牙桑路卡拉马尤城的一座新型PS20塔式太阳能电站。被称为&日光反射装置&的镜子将太阳光反射到主塔,然后用聚集的热量产生蒸汽进而通过涡轮机转化为电力