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The results showed that the addition leading to -2-phenyl-2-(2-vinylpiperidin-1-yl) ethanol 7 could proceed with good diastereoselectivity and excellent yield (95%).(3) The selective N-deprotection of -2-phenyl-2-(2-vinylpiperidin-1-yl) ethanol 2 without affecting the vinyl group in the substrate were untaken.(4) The Zip reaction for the transformation of -1-(3-aminopropyl)-3-methylazecan-2-one 8 to -7-Methyl-1, Sdiaza-cyclotetradecan-6-one 9 were undertaken. The results showed that, under controlled conditions, acceptable yields (43%) could be achieved and racemization can be minimized during the ring expansion reaction.

该合成路线与文献方法相比,反应条件较温和,也缩短了反应时间;(2)哌啶衍生物2与乙烯基格氏试剂进行加成反应的条件和立体选择性,取得了较好的结果(差向异构体比为80:20,产率95%左右);(3)不饱和哌啶衍生物7在不影响碳碳双键的情况下去除苯基甘氨醇手性辅助基的条件;(4)具有羰基α位手性的氨基酰胺8在不同条件下经Zip重排反应转变为9的反应,控制反应条件,可使反应中消旋化减小到最小的程度。

NAC also blocked the up-regulation of TGF-β in in vivo model of VILI. Conclusion TGF-β1 and TGF-β2 were up-regulated in VILI. Oxidant injury mediated up-regulation of TGF-β in VILI. NAC, which attenuated oxidant injury and blocked TGF-β up-regulation in VILI, could be a future therapeutic strategy in VILI.

结论TGF-β1和TGF-β2在通气机所致肺损伤中的表达增加并在血清中上调;TGF-β上调的机制与氧自由基损伤有关但与肿瘤坏死因子无关;N-乙酰半胱氨酸可对抗氧自由基损伤,能阻断TGF-β的上调,可能成为呼吸机相关肺损伤的一种新治疗途径。

Protein nitrogen accumulation in leaf-stems of Yuchi 231 was significantly lower than those of 4434 and Dianrui 302, while that was significantly higher in grains, suggesting higher nitrogen accumulation in grains was a key characteristics of the rice genotype with high NHI.

余赤231灌浆期叶片和籽粒谷氨酰胺合成酶和谷氨酸合成酶活性显著高于4434和滇瑞302,有利于叶片游离氨基酸合成及外运,使得穗颈节伤流强度和游离氨基酸含量升高,为籽粒氮素积累提供了物质基础;同时,较高的籽粒Gs和GOGAT活性促进了籽粒蛋白质合成,提高了NHI。

ABSTRACT:Objective To study the feasibility of non-invasive magnetic resonance spectroscopy in measuring glutamine level in Zelanian rabbits' skeletal muscle.

目的 探讨应用磁共振波谱技术无损伤测定新西兰兔骨骼肌组织中谷氨酰胺含量的可行性。

PBMC treated with inhibitor N-tosyl phenylalanine chlormethyl ketone, Astragalus can increase the activity of NF-κ B and the concentration of IL-8 in patients with PNS. it also increases the the activity of NF-κ B in normal children , but can ' t affected the concentration of IL-8 in normal children. ConclusionIn patients with PNS , the activity of NF-κ B was up-regulated and the level of IL-8 was significantly elevated.

结果肾病患儿 NF-κ B 活性及 IL-8含量增高,2者呈正相关; IL-1β刺激后,黄芪降低肾病患儿 NF-κ B 活性及 IL-8含量、降低正常儿童 NF-κ B 活性而不影响 IL-8含量;用对甲苯磺酰-L-苯丙氨酸氯甲基甲酮抑制后,黄芪可提高肾病患儿 NF-κ B 活性及 IL-8含量、提高正常儿童 NF-κ B 活性;而不影响 IL-8含量。

The method was validated for acetylated peptides and allowed an assessment of even the basal protein phosphorylation of phenylalanine hydroxylase in intact cells.

该方法被确证乙酰酶多肽,并允许在不完整细胞中对苯丙氨酸羟化酶的基本蛋白质磷酸化的评估。

Effects of processing parameters such as transglutaminase concentration, pH value of film-forming solution and air-drying temperature on the properties of TGase-modified soy protein isolate films were studied in this manuscript.

研究了酶浓度、成膜溶液的pH值、干燥温度等工艺参数对谷氨酰胺转移酶改性大豆分离蛋白膜性能的影响。

Essentially, if you don't have glutamine, the cell is short circuited due to a lack of glucose, which halts the growth of the tumor cell Ayer says.

基本上,如果没有谷氨酰胺,细胞生长由于没有糖类而发生短路现象,从而减缓肿瘤细胞的生长, Ayer博士说。

However, the mechanism of Gins protection in these patients remains unclear.

但是,谷氨酰胺在这些患者中发挥保护作用的机制仍不清楚。

Even conventional medicine recognizes this, as anyone who overdoses on it receives large doses of N-acetyl cysteine in the emergency room.

即使承认这一传统医药、正如任何人在接到大剂量的过量乙酰半胱氨酸在急诊室。

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