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A single point mutation in intervening sequence 2 (IVS2) of human mitochondrial arginyl-tRNA synthetase gene causes abnormal cleavage of its transcript, resulting in pontocerebellar hypoplasia.

人线粒体精氨酰-tRNA合成酶基因2号内含子中的一个单点突变导致该基因的转录本被异常剪接,造成脑桥小脑发育不全。

Our study focused upon the precentral gyrus to determine whether any signal changes could be detected in ALS patients; and to determine whether riluzole can reverse corticomotoneuron damage in patients with ALS.

质子磁共振波谱是一种可以无创性定量测定在体脑内生化物质的方法,在对ALS病人双侧大脑中央前回进行质子波谱分析后显示:(1)NAA/Cr (N-乙酰门冬氨酸/肌酸)比值在ALS病人上显著降低,P.01。

The parenteral nutrition therapy with give glutamine can improve immune function and decrease the plasma endotoxin ,there were no significant different in the hospital stay and hospitalization expenses of the proctectomy patients.

结论含谷氨酰胺二肽的肠外营养能改善患者免疫功能,减轻术后患者内毒素血症,但对住院时间及住院费用没有明显影响。

The reverse transcription-polymerase chain reaction was used to seek the expressions of a specific fibroblast marker, prolyl 4-hydroxylase β, and a specific marker of epithelial cells, cytokeratin-4, in the cells.

采用逆转录多聚酶链反应检测hEFs表达成纤维细胞特异性标志(脯氨酰4-羟化酶β亚单位)和上皮细胞特异性标志(细胞角蛋白4)的情况,对该细胞进行鉴定。

One of the potential advantages of the hypoxia-induced factor prolyl hydroxylase inhibitor approach to anemia therapy over ESA is improved regulation of iron absorption and iron recycling to improve the efficiency of iron utilization, partially via a mechanism of hepcidin suppression, to overcome functional iron deficiency.

用作贫血治疗的缺氧诱导因子脯氨酰羟基化酶抑制剂相对于红细胞生成作用刺激剂的一个优势是铁吸收和铁再利用的调节得到改善,提高了铁利用的效率,尤其是通过铁调节蛋白抑制机制,克服功能性铁缺乏。

Inhibition of prolyl hydroxylase activity or expression can be effected using competitive inhibitors such as dimethyloxalylglycine or siRNA leading to the stabilization of HIF and other beneficial effects.

DMOG是一种脯氨酰羟化酶抑制剂,能够抑制细胞内HIF-1α的降解,继而使细胞核内很多基因(如EPO、VEGF、Ang1和Glut-1等)的转录和表达增高,继而发挥其保护性作用。

Results The hEFs were successfully isolated and cultivated from gonadal ridges and dorsal mesenteries of human embryos. They could be passaged beyond the 25th generation. The biologic characteristics of the cells did not change, even in high-passage cells or frozen-thawed cells. The cells expressed prolyl 4-hydroxylase β, but not cytokeratin-4, which was similar to the fibroblasts. The cultured cells expressed bFGF and LIF.

结果:从人胚胎生殖腺嵴和肠背系膜中成功地分离培养出hEFs,该细胞可传25代以上,且经过传代及冻存复苏后生物学特性无改变;hEFs表达脯氨酰4-羟化酶β亚单位,不表达细胞角蛋白4,确定其为成纤维细胞;该成纤维细胞表达bFGF和LIF。

With sodium acetate as catalyst, inosine was esterified with acetic anhydride in the yield of 92% to give 2',3',5'-triacetyl inosine, which was treated with pyridine and phosphorus oxychloride to form a pyridinium solution, followed by performing an amination at 40℃ and 0.25~0.30 MPa to achieve adenosine in the yield of 67%.

肌苷在醋酸钠存在下与醋酸酐发生酯化反应以92%的收率得到2',3',5'-三乙酰肌苷,其化合物经吡啶和三氯氧磷处理形成吡啶盐溶液,未分离直接在40℃、0.25~0.30 MPa压力下进行氨解反应以67%产率制得腺苷。

The PASP is synthesized by means of pyrocondensation polymerization, using maleamic acid as a monomer.

以马来酰胺为单体,采用热缩聚法,合成了聚天冬氨酸PASP

Beijing University of Chemical Technology, Beijing 100029, ChinaAbstract: The PASP is synthesized by means of pyrocondensation polymerization, using maleamic acid as a monomer. The infrared spectrogram and molecular weight of synthetic products are determined.

摘要]以马来酰胺为单体,采用热缩聚法,合成了聚天冬氨酸,对其测定了红外谱图和相对分子质量,研究了可生物降解性、阻垢性能及阻垢性能与相对分子质量的关系。

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