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Methods Starting from 2-chloro-4-nitrophenol and 2- pyridine hydrochlorid, 3-chloro-4-(pyridin-2-ylmethoxy) aniline was obtained via etherization and reduction. The obtained aniline coupled with N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) acetamide to give 4-[3-chloro-4-(2-pyridylmethoxy) phenylamino]-3-cyano-7-ethoxy-6-N-acetylaminoquinoline. And then it was deacetylated, followed by reacting with4- but-2-enoyl chloride to yield the target compound neratinib.

以2-氯-4-硝基苯酚和2-氯甲基吡啶为起始原料,经醚化、硝基还原得到3-氯-4-(吡啶-2-甲氧基)苯胺,3-氯-4-(吡啶-2-甲氧基)苯胺与3-氰基-6-乙酰氨基-7-乙氧基-4-氯喹啉反应得到3-氰基-6-乙酰氨基-4-[3-氯-4-(吡啶-2-甲氧基)苯氨基]-7-乙氧基喹啉,3-氰基-6-乙酰氨基-4-[3-氯-4-(吡啶-2-甲氧基)苯氨基]-7-乙氧基喹啉去乙酰保护基后,与-4-二甲氨基-2-丁烯酰氯经酰化反应得到ner-atinib。

Three formyl group functional cross-linking polystyrene resins of p -formylphenoxymethyl, p -formyl-2-methoxphenoxymethyl,and p -formyl-3-methoxphenoxymethyl were facilely and rapidly synthesized from Merrifield resin under phase transfer catalytic condition coupling with microwave irradiation in a domestic microwave oven.

以Merrifield树脂为原料,家用微波炉为反应装置,在微波照射的相转移催化条件下,简便快速地合成了3种甲酰基功能化的交联聚苯乙烯树脂——对甲酰基苯氧基甲基树脂、对甲酰基-2-甲氧基苯氧基甲基树脂和对甲酰基-3-甲氧基苯氧基甲基树脂。

Three formyl group functional cross-linking polystyrene resins of methoxphenoxymethyl, and p-formyl-3-methoxphenoxymethyl were facilely and p-formylphenoxymethyl, p-formyl-2-rapidly synthesized from Merrifield resin under phase transfer catalytic condition coupling with microwave irradiation in a domestic microwave oven.

以Merrifield树脂为原料,家用微波炉为反应装置,在微波照射的相转移催化条件下,简便快速地合成了3种甲酰基功能化的交联聚苯乙烯树脂--对甲酰基苯氧基甲基树脂、对甲酰基-2-甲氧基苯氧基甲基树脂和对甲酰基-3-甲氧基苯氧基甲基树脂。

The effects of spatial hindrance , solvent, free volume were investigated. The result showed that the structure of graft copolymers exhibit a marked influence on photoisomerization.

另外,邻位被丙烯酰氧基取代的偶氮聚合物还表现出光致变色性禁阻,这说明空间位阻起了一个非常重要的作用。

Rosolic acid reacted with acetic anhydride to synthesize rosolic acid -triacelate ester [tri(4-acetoxy) phenyl methane] under reflux condition.

以玫红酸、醋酸酐为原料,采用加热回流法合成了玫红酸三乙酸酯[三(4-乙酰氧基)苯基甲烷]。

The effect of emulsifying agent and neutralisation level on the stability of the polymeric system was investigated.

以丙烯酰氧基Span-80为乳化剂,采用反相乳液聚合法合成了高分子量聚丙烯酸钠。

The result of potassium malonyloxyborohydride as a new hydroboration reagent reacts with terminal alkenes and alkynes is described.

介绍新的硼氢化试剂丙二酰氧基硼氢化钾与链端烯炔烃的作用,烯烃的硼氢化物在PTC条件下,插入∶CCl2 ,可得饱和羧酸;炔烃则难以与之硼氢化。

A series of p hydroxybenzoic acid oligomers were synthesized of p acetoxybenzoic acid (4 ABA).

用对乙酰氧基苯甲酸合成了一系列对羟基苯甲酸的齐聚物,由于这些齐聚物不溶于大部分有机溶剂,因此尝试用傅立叶红外谱半定量地分析齐聚物的聚合度。

A series of p hydroxybenzoic acid oligomers were synthesized of p acetoxybenzoic acid (4 ABA). Since the oligomers are insoluble in most organic solvent, we tried to analyze the degree of polymerization of the oligomers half stoichiometricly by the FT IR method.

用对乙酰氧基苯甲酸合成了一系列对羟基苯甲酸的齐聚物,由于这些齐聚物不溶于大部分有机溶剂,因此尝试用傅立叶红外谱半定量地分析齐聚物的聚合度。

Malonyloxyborohydride,a hydroboration reagent,is prepared by reaction of malonic acid and sodium borohydride,and is used to react with dihydromyrcene in THF.

用一种硼氢化试剂———丙二酸与硼氢化钠反应生成的丙二酰氧基硼氢化钠在THF中与二氢月桂烯反应制备香茅醇。

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推荐网络例句

We have no common name for a mime of Sophron or Xenarchus and a Socratic Conversation; and we should still be without one even if the imitation in the two instances were in trimeters or elegiacs or some other kind of verse--though it is the way with people to tack on 'poet' to the name of a metre, and talk of elegiac-poets and epic-poets, thinking that they call them poets not by reason of the imitative nature of their work, but indiscriminately by reason of the metre they write in.

索夫农 、森那库斯和苏格拉底式的对话采用的模仿没有一个公共的名称;三音步诗、挽歌体或其他类型的诗的模仿也没有——人们把&诗人&这一名词和格律名称结合到一起,称之为挽歌体诗人或者史诗诗人,他们被称为诗人,似乎只是因为遵守格律写作,而非他们作品的模仿本质。

The relationship between communicative competence and grammar teaching should be that of the ends and the means.

交际能力和语法的关系应该是目标与途径的关系。

This is not paper type of business,it's people business,with such huge money involved.

这不是纸上谈兵式的交易,这是人与人的业务,而且涉及金额巨大。