酰化作用

The purpose of this current study was to understand the role of acetylation in regulating Hsp90 function.

当前研究的目的是明确乙酰化在调节Hsp90功能中所起的作用。

In the recent decade, more and more attention has been paid to the roles of acetylation in transcription regulation.

尤其是近十多年来，乙酰化在真核生物基因表达调控中的作用日益受到人们的关注。

Backgroud: The acetylation of histones plays very important role in expression of gene.

研究背景：组蛋白乙酰化修饰在基因表达调控中有非常重要的作用和意义。

Lysine acetylation is a reversible posttranslational modification of proteins and plays a key role in regulating gene expression.

赖氨酸乙酰化是可逆的蛋白翻译后修饰，在基因表达调控中起重要作用。

Our data demonstrate that the regulatory scope of lysine acetylation is broad and comparable with that of other major posttranslational modifications.

我们的数据显示赖氨酸乙酰化是一种调节范围很宽的翻译后修饰作用。

On the other hand, we suggest that the STAT3-induced histone deacetylation in the IL-4 promoter may play an initial role in IL-4 suppression.

另一方面，我们认为STAT3诱导的IL-4启动子组蛋白去乙酰化在IL-4基因的抑制中发挥了起始性的作用。

Recent development in hydroformylation of ethene to propanal by catalytic synthesis is introduced in this paper.

目前世界上工业化生产丙醛多采用乙烯氢甲酰化反应催化合成，即用乙烯、CO和H2 在催化剂作用下合成丙醛。

HDAC1 has been shown to interact with many key hematopoiesis transcription fators and to influence their activities.

组蛋白去乙酰化酶在血细胞生成和白血病生成中发挥着重要的作用。

Objective Consequently, by constructing the pcDNA3-HA-hdacl, a HDAC1 eukaryotic expression vector, we were to study the interaction between HDAC1 and ERa and ERB in vitro and the effects of HDAC1 on the ERa and ERB at the protein level. So we can partly reveal the multiplication, differentiation and cancerization of lacteal gland cells.

目的 本文意在通过构建可在真核细胞中表达的重组质粒pcDNA3-HA-hdacl，研究组蛋白去乙酰化酶1(HDAC1)和雌激素受体ERα和ERβ在体外的相互结合作用，以及HDAC1对ERα和ERβ蛋白水平的影响规律，从而在一定角度揭示乳腺细胞的增殖、分化和癌变的过程，为更好地寻找治疗癌症的药物靶标打下基础。

We demonstrate that both the IL-5 mRNA expression and IL-5 protein production were stimulated by TSA and NaBu treatments. Chromatin immunoprecipitation assays showed that treatments of TSA and NaBu caused hyperacetylation of histones H3 and H4 at the IL-5 gene promoter in Jurkat cells, which consequently promoted the exogenous luciferase activity driven by this promoter.

TSA和丁酸钠能促进IL-5基因的mRNA和蛋白的表达水平，并增强该基因启动子所介导的外源荧光素酶报告基因的活性，这一增强作用与两种抑制剂介导的IL-5基因启动子上组蛋白H3和H4的高乙酰化有关。

James, son of Zebedee, and John the brother of James, whom he named Boanerges, that is, sons of thunder

载伯德的儿子雅各伯和雅各伯的弟弟若望，并为他们起名叫"波纳尔革"，就是"雷霆之子"

The southern Hungarian university city of Szeged will host part of the project, amounting to 40 percent of the total investment, which will mostly be paid for through Hungary's EU structural funds.

位于塞格德南部的匈牙利大学将负责部分项目，总计占总投入资金的40%。大部分资金将由匈牙利的欧盟结构基金会支付。