酰化作用

Post-translational modification of proteins which contains phosphorylation, acetylation and methylation has attracted more and more attention because of its important role in organism.

蛋白翻译后修饰如磷酸化、乙酰化和甲基化等在生命活动过程中发挥的重要作用使其成为近年来的研究热点。

In the acylation reaction between anisole with acetyl chloride, The catalyst of ZnCl〓/HY-98 prepared by MWI had the best catalytic activity and the selectivity of p-methoxy acetopheone. The catalytic active centers were ZnCl〓 dispersed in zeolite and the Bronsted acid sites in HY-98 zeolite itself.

在苯甲醚与乙酰氯的酰化反应中，微波固相法制备的ZnCl〓／Y催化剂有相对较好的催化活性和选择性，起催化作用的主要是分散在分子筛表面的ZnCl〓和分子筛本身的B酸。

The types of histone methyltransferases, the relationship between methylation of Lysine 9 of H3 and the formation of heterochromatin, gene regulation in euchromatin, and that with DNA methylation, were mainly introduced.

主要阐述了组蛋白甲基转移酶的类型，组蛋白H3中第9位赖氨酸甲基化与异染色质的形成、常染色体中基因表达的调控，以及与DNA甲基化之间的关系，说明了组蛋白甲基化与组蛋白乙酰化、磷酸化的相互关系，指出组蛋白甲基化对维持细胞各种状态的平衡起到极其重要的作用。

The molecular charge distribution of the reactivator is affect the reactivating efficacy directly. Moreover its association with hydroximic acid dissociation constant pAa closely, and it will have a great impact on reactivating ability indirectly.(3) There is likely to exist front molecular interaction between Cholinesterase Reactivators and OPC-inhibited AChE, the action sites mainly lie on the aromatic ring, the substitute R and the hydroixic acid group. They act on the aromatic residues of AChE by Π-Π conjugation .(4) The reached results by Comparative Molecular Field Analysis is useful to design new higher efficacy derivatives for 1, 2, 4-oxadiazole class nonquaternary Cholinesterase Reactivators.

2复能剂分子的电荷分布直接影响复活活性，同时对肟酸解离常数pKa具有重要影响，间接影响复活能力；(3)复能剂与磷酰化酶可能存在前线轨道作用，作用部位可能主要在芳香环及其取代基R和肟基上，与AchE的芳香族残基发生л-л电子作用；(4)通过比较分子力场法研究可以指导1，2，4-oxadiazole类非季铵肟胆碱酯酶重活化剂新化合物的合成，可能得到活性更高的复能剂。

Pharmacological results also indicated that the carbonyl and imino of Z-47 are important to its marked antiinflammatory and analgesic activity. The activity will be reduced or abolished with Z-47 converted to oximes or/and acetamides.

药理结果还表明，Z-47结构中的羰基和仲胺基对Z-47的显著抗炎镇痛作用具有重要的贡献，将Z-47羰基变成肟或／和将Z-47仲胺基酰化都会造成抗炎镇痛作用的降低甚至是丧失。

Methods n-Cetyl-l-thio-β-D-galactoside was synthesized by a series of reaction from galactose and incorporated into Small Unilamellar Vesicles which was prepared by sonication at the ratio for L-α-PC∶Chol∶L-α-PE as 7∶2∶1, with or without 10 mol%Cetyl-gal.

半乳糖经乙酰化、溴化、缩合、亲核取代反应制备半乳糖新糖脂质并与其他脂质制备脂质体，在二氯化锡还原作用下用99mTc标记脂质体，进行动物体内靶肝实验，用γ计数器检测各脏器放射性，计算摄取率。

The over expression of p33^ING1b can promote the expression of p21^WAP1 which cooperates with p53 to restrain the cell growth by regulating the activity of the acetylating depended pathway.

ING1编码的蛋白通过组蛋白乙酰转移酶和组蛋白去乙酰化酶参与染色质的重塑，在DNA损伤修复方面发挥重要作用。

Triacylglyceride An ester of glycerol in which all the-OH groups are esterified; the acyl groups may be the same or different.

三酰甘油酯：甘油的所有三个-OH 都发生酯化作用，而酰基可发生变化或保持不变而得到的酯。

However, relatively lower column utilization limits its application to the complex proteome isolation. In case of binding biotin molecules to a specific kind of functional groups existed in protein structure, and flowing the digested peptides over the affinity column in which avidin has been immobilized, biotinylated peptides can be selectively separated and the complicated system is simplified.

因此根据需要，变换生物素试剂与蛋白质反应的作用位点，就可以选择性地分离出不同的目标肽段，从而大大提高亲和色谱柱的使用效率，降低亲和分离的成本；结合乙酰化同位素标记技术，还可以建立多种针对不同目标肽段的特色定量分析方法，ICAT即是将同位素标记与蛋白质巯基生物素化亲和分离成功结合的一个范例。

Some stimulators, including viruses, tumor cells and hot shock, could promote the expression of NKG2 receptors and their ligands via activating certain transcription factors which are capable of up-regulating NKG2 promoters' activity. Meanwhile, epigenetic mechanisms including DNA methylation and histone posttranslational modifications are also critical to expression of NKG2 receptors and their ligands and may control the clonally distribution of some NK cell receptors.

病毒、肿瘤和热休克等刺激可以通过激活相应的转录调节因子，提高启动子活性而上调NKG2家族受体及其配体的表达，而启动子区DNA的甲基化状态、组蛋白的乙酰化和甲基化等表观遗传调控，在NK细胞受体及其配体的表达方面亦起重要作用，并决定NK细胞受体的克隆性分布。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新