酰化作用

The immunoregulation activity of SPG-1 mainly existed in the part of sugar chain, but keeping its molecular structure intact had some effects on its immunoregulation activity; SPG sulphation had reducing effects on the immunoregulation of SPG-1, whereas, after medium and low acetification of SPG, the immunoregulation of SPG was enhanced. Conversely after high acetification, the immunoregulation of SPG-1 decreased, that is, after introducing sulfuric and acetic acid base in SPG-1, its immunoregulation changed. All of these indicated the structure of SPG-1 was closely connected with its immune activity.⑤.

甘薯糖蛋白SPG-1的免疫调节活性主要在其糖链部分，但保持分子结构的完整性对其免疫调节的活性有一定的作用；甘薯糖蛋白硫酸化对甘薯糖蛋白SPG-1的免疫调节有降低作用，而中、低度乙酰化后，可提高甘薯糖蛋白的免疫调节作用，高度乙酰化后则降低其免疫调节作用，即甘薯糖蛋白引入乙酰基和硫酸基团后，其免疫调节活性发生了改变，这些均表明了甘薯糖蛋白的结构与其免疫调节活性有密切的关系。

This is further supported by the demonstration that Elp3 promotes acetylation and counteracts HDAC6-mediated deacetylation of this substrate invitro.

Elp3对乙酰化的促进作用，和对HDAC6介导体外基质乙酰化的阻碍作用，更进一步的证实了上述观点。

ABSTRACT Immobilized penicillin acylase (from E.coli) was used to catalyze 7 phenylacetamido 3 E propenyl cephalosporanic acid hydrolyzation into 7 amino 3 E propenyl cephalosporanic acid. Then, trans APRA was acylated with hydroxyethyl ester of 4 hydroxy D phenylglycine to obtain trans cefprozil.

以7 苯乙酰氨基 3 E 丙烯基 3 头孢菌素 4 羧酸为原料，在青霉素酰化酶作用下，首先酶法水解得到3 E 丙烯基 3 头孢菌素 4 羧酸，过滤固相酶，滤液调pH分离得到反式APRA固体；在青霉素酰化酶作用下，反式APRA再与对羟基苯甘氨酸乙二醇酯缩合，得到反式头孢丙烯；酶法合成所得的产品与进口反式头孢丙烯对照品一致。

Significant processing steps can include: a phase changes involving either the desired molecule or the solvent, inert carrier or vehicle, e.g., dissolution, crystallization, evaporation, sublimation, distillation or absorption; b a phase separation such as filtration or centrifugation; c any chemical change involving the desired molecule, e.g., removal or addition of water of hydration, acetylization, formation of the salt; d an adjustment of the solution containing the molecule such as adjustment of pH or pO2; e a precision measurement of contained or added BPC components, in-process solutions, recycled materials is performed, i.e., weighing, volumetric measuring, optical rotation, spectrophotometric determinations, etc.; and f changes occur in surface area, particle size, or lot uniformity, e.g., milling, agglomeration, blending.

意义较大的步骤可能会包括：a相变化，包括指定分子或溶剂，惰性载体或溶媒，如溶出作用，结晶，蒸发，升华，蒸馏或吸附；b相分离，如过滤或离心；c涉及指定分子的任一化学变化，如结晶水的除去或添加，乙酰化作用，成盐；d包含分子的溶解的调节，如调节pH或pO2；e 含有或添加原料药组分，过程内溶液，回收物料的精密测量，如，称重，体积测量，旋光度，分光光度测定，等和f 表面，粒度，或批一致性的变化，如磨碎，凝块，混合。

Histone acetyltransferases and deacetylases function antagonistically to control histone acetylation.

组蛋白的乙酰化在调节染色体结构和功能中起着重要的作用，而这种调节受组蛋白乙酰化酶和去乙酰化酶的共同调节。

The effect of N-phosphoamino acids on plant cells'membrane permeability was investigated by osmotic method. It was found that in all N-phosphoamino acids, only some phosphoryl polar amino acids such as DIPPSer, DIPPThr, DIPPHis, DIPPAsp, DIPPGlu, DIPPAsn and free serine, threonine could increase the water permeability in plant cell membrane. For example, after 20min. treatment by 1. 5mM DIPPSer, the deplasmolysis time of onion cells was shortened 50%.

三、通过透性实验研究了N-磷酰化氨基酸对洋葱、豌豆等植物细胞膜水透性及溶质透性的影响，发现在所有的N-磷酰化氨基酸及自由氨基酸中，仅有部分N-磷酰极性氨基酸和自由的丝、苏氨酸对植物细胞膜上水透性有增强作用，如1.5mM N-磷酰化丝氨酸可使洋葱细胞质壁复原时间缩短一半以上。

A process for preparingp-fluo-2-(2-methyl-3-propionyl)-4-oxy-N,3-diphenyl-phenylbutylamide includes such steps as Friedle-Craft acylating of newly prepared phenylacetyl chloride and fluorobenzene under catalysis of AlCl3 to obtain 4-fluoro-phenylbenzyl ketone, brominating at carbonyl alpha position under catalysis of less AlCl3 to obtain alpha-bromo-4-fluo-phenylbenzyl ketone, and condensing with isobutyryl acetanilide under action of sodium ethoxide.

本发明涉及一种制备对氟－2－(2－甲基－3－氧丙基)－4－氧－N，3－二苯基－苯丁酰胺(1)的方法，其包括以下步骤：新制的苯乙酰氯与氟苯在AlCl3催化下进行Friedle－Craft酰化反应，得到对4－氟－苯基苄基酮(4)；化合物(4)在少量AlCl3催化下进行羰基α位溴化，得到α－溴－4－氟－苯基苄基酮(5)；然后(3)异丁酰乙酰苯胺在乙醇钠作用下与化合物(5)进行缩合。

To elucidate the possible mechanism of differentiation and /or apoptosis in NB4, K562 cells induced by tributyrin, a histone deacetylase inhibitor, the level of acetylated histone H3 was detected by Western blot, p21~ WAF1expression was detected by semi-quantitative RT-PCR.

为了探讨组蛋白去乙酰化酶抑制剂三丁酸甘油酯(tributyrin，TB)诱导NB4、K562白血病细胞分化和凋亡的作用机制，利用Westernblot方法及逆转录聚合酶链反应检测TB作用前后NB4、K562细胞组蛋白H3乙酰化水平以及p21WAF1表达量的改变。

To elucidate the possible mechanism of differentiation and/or apoptosis in NB4, K562 cells induced by tributyrin, a histone deacetylase inhibitor , the level of acetylated histone H3 was detected by Western blot, p21(superscript WAF1) expression was detected by semi-quantitative RT-PCR.

为了探讨组蛋白去乙酰化酶抑制剂三丁酸甘油酯(tributyrin， TB)诱导NB4、K562白血病细胞分化和凋亡的作用机制，利用Western blot方法及逆转录聚合酶链反应检测TB作用前后NB4、K562细胞组蛋白H3乙酰化水平以及p21(上标 WAF1)表达量的改变。

The kinetics of reconstitution of apoacylase with either 〓 or 〓 and the inactivation of the 〓 reconstituted enzyme by 1, 10-phenanthroline has been studied by following the substrate reaction continuously in presence of the metal ion or OP respectively. Although the native 〓-containing and the 〓-reconstituted enzymes have closely similar Michaelis constants and maximal velocities, the kinetics for both the inactivation by OP and the reconstitution of the apoenzyme with the metal ions differs considerably.

虽然钴重组的氨基酰化酶与天然含锌的氨基酰化酶在催化活性上比较相近，但两种酶在去金属失活动力学机制以及去金属失活的氨基酰化酶与两种金属离子重组复活的动力学过程均存在较大的差异，说明锌在氨基酰化酶中的作用比较复杂，并不能完全由钴替代。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新