酰化

BMI-1(B-cell-specific Moloney murine leukemia virus integration site 1), a Polycomb group repressor, is always present as a PcG complex combined with RING1, HPC2, Mph2, et al. BMI-1 prolongs cells'capacity to proliferate and represses their senescence by repressing the transcription of CDKN2A through acetylhydrolasing or deacetylhydrolasing the Polycomb response elements in chromosome.

BMI-1 (B-cell-specific Moloney murine leukemia virus integration site 1)属于PcG家族，它与该家族其他成员如RING1，HPC2，Mph2等结合形成蛋白复合体，作用于染色质PREs位点，通过对组蛋白进行乙酰化和去乙酰化修饰，从而稳定抑制CDKN2A转录，最终促进细胞的增殖并抑制细胞凋亡。

The patients with rheumatoid arthritis with the slow NAT2 acetylator genotypes have been shown to have more side effects than fast acetylator genotypes when taking SASP.

同时也有研究发现慢型乙酰化表型的风湿性关节炎患者在服用SASP后，与快型乙酰化表型患者相比，副反应发生率明显升高。

The acylation method s of determining hydroxyl value of polyether in the industry and scientific presently research was introduced.

介绍了工业生产和科研中常用的酰化法测定聚醚羟值的方法，讨论了在酰化过程中影响实验结果的各种因素，简要介绍和分析了其解决措施。

The effects of degree of acylation of chitosan and addition of lecithin on the behavior of O, O-dilauroyl chitosan self-assembled vesicles were studied in this work.

考察了3种不同酰化取代度的O， O–双十二酰化壳聚糖自组装泡囊的体外药物（维生素B12）释放行为。

In this review, we discussed the consequences of inhibiting histone deacetylases in cycling versus non-cycling cells, in light of the dynamics of histone acetylation patterns with a specific emphasis on heterochromatic regions of the genome.

本综述通过讨论HDACIs对周期和非周期细胞中组蛋白去乙酰化酶的抑制结果，来阐明组蛋白乙酰化模式的动力学特征，特别是对基因组异染色质的作用。

A diverse range of effects:on protein solubility and secretion was observed,and these effects were highly dependent on the particular chaperone.In the host strain over-expressing chaperone SecB harboroing pSecB,the amount of total periplasmic proteins was increased by about 71％and the activities of alkaline phosphatseand GL-7-ACA acylase(GL7A)were increased by about 54％and l.5-fold respectively.In the host strain over-expressing chaperone GroEL bearing pGroEL,the amount of total periplasmic proteins was increased by 52％,and the activity of penicillin G acylasewas in creased by about 76％;about 90％of Hexameric Calcitonin(Cal6)inclusion body and l5％of MS2interleukin3(MS2-HIL3)inclusion body became soluble respectively.All the data were compared with the parental strains un-bearing plasmdis pSecB or pGroEL.

在过量表达SecB的宿主菌中，周质空间分泌蛋白总量较对照组提高了约71％，GL-7-ACA酰化酶在周质空间酶的活力较对照组提高了约1.5倍，碱性磷酸酯酶在周质空间酶的活力较对照组提高了约54％；在过量表达GroEL的宿主菌中，周质分泌蛋白总量较对照组提高了约52％，青霉素G酰化在周质空间酶的活力较对照组提高了约76％，鲑鱼降钙素六聚体的可落性组分的比例由原来的45％增加到约90％，而MS2-人白介素-3融合蛋白的包涵体有约15％转变为可溶性组份。

ABSTRACT This thesis focused on the studies of setereoselectively total synthesis of naturally occurring bisabolane sesquiterpenes and hydroxamic acid derivatives; it contains the following five parts: Part Ⅰ: Hydroformylation reaction have been taken an overview for past 40 years.

本论文主要对防风根烯类倍半萜天然产物和羟肟酸类化合物的全合成进行了研究，内容概要如下：一、对近年来氢甲酰化反应——特别是不对称氢甲酰化反应作了详尽的综述。

Benzoylated phenyl a - and B - 2 - thio - D - fructofuranosides were synthesized and coupled with protected sucrose acceptor to synthesize a - D - fructofuranoside - linkage stereospecifically by employing NIS/AgOTf as catalysts.

在果糖的合成研究中，合成了四苯甲酰基苯基果糖硫苷，并首次将其用作糖苷化反应的给体，在NIS/AgOTf的促进之下，与乙酰化保护的蔗糖受体反应，从而以高产率立体专一地合成了α构型的呋喃果糖苷。

To elucidate the possible mechanism of differentiation and /or apoptosis in NB4, K562 cells induced by tributyrin, a histone deacetylase inhibitor, the level of acetylated histone H3 was detected by Western blot, p21~ WAF1expression was detected by semi-quantitative RT-PCR.

为了探讨组蛋白去乙酰化酶抑制剂三丁酸甘油酯(tributyrin，TB)诱导NB4、K562白血病细胞分化和凋亡的作用机制，利用Westernblot方法及逆转录聚合酶链反应检测TB作用前后NB4、K562细胞组蛋白H3乙酰化水平以及p21WAF1表达量的改变。

To elucidate the possible mechanism of differentiation and/or apoptosis in NB4, K562 cells induced by tributyrin, a histone deacetylase inhibitor , the level of acetylated histone H3 was detected by Western blot, p21(superscript WAF1) expression was detected by semi-quantitative RT-PCR.

为了探讨组蛋白去乙酰化酶抑制剂三丁酸甘油酯(tributyrin， TB)诱导NB4、K562白血病细胞分化和凋亡的作用机制，利用Western blot方法及逆转录聚合酶链反应检测TB作用前后NB4、K562细胞组蛋白H3乙酰化水平以及p21(上标 WAF1)表达量的改变。

By the time of its fall, most of the prisoners were writers who had written against the corruptions of the government.

到它被攻陷的时候，里面多数的犯人是写了反对政府贪污文章的作家。

The most obvious variation to ovum morphological character was that the color was changed from light green to sepiaceous in embryonic development, and all the ovums were almost hatched after 96h.

在胚胎发育过程中卵的形态特征最明显的变化是颜色从淡绿到深褐色，卵在发育96h后卵基本全部孵化。