酰化

HDAC1 has been shown to interact with many key hematopoiesis transcription fators and to influence their activities.

组蛋白去乙酰化酶在血细胞生成和白血病生成中发挥着重要的作用。

Increased hepatic acetylation of histone H3 in the IUGR offspring might be caused by decreased HDAC1 expression in nuclear protein. This may contribute to the transcription change of some genes in the hepar.

IUGR大鼠肝细胞核中HDAC1蛋白表达降低，引起组蛋白H3的乙酰化水平增高，染色质的表观遗传学变化可能是肝脏某些基因转录调控变化的分子基础。

Methods:The target compounds were synthesized from acylation of polyethylene glycol to hydroxy group of ursolic acid by polymer polycondensation method.

通过高分子缩合的方法，将酰化的聚乙二醇接枝到熊果酸的羟基上，得到目标产物。

Aim To prepare lower degree of substituted starch acetate with cassava starch as material, acetic anhydride as acetylation reagent, sodium hydroxide as catalyst and sodium sulfate as gelatinization inhibiter.

目的 以木薯淀粉为原料，醋酸酐为乙酰化试剂，NaOH为催化剂，Na2SO4为膨胀抑制剂，制备了低取代度木薯淀粉醋酸酯。

Inulin has been modified by carbamoylation in organic solvents.

菊糖与十八烷基异氰酸酯在有机溶剂中发生甲氨酰化反应，生成的氨甲基菊糖具有表面活性。

However, LeuRS-B can catalyze mischarging of tRNA〓 by methionine or isoleucine, suggesting that it is impaired in the ability to edit incorrect products.

然而，LeuRS-B可以错误的催化异亮氨酸和甲硫氨酸误氨酰化tRNA〓，这说明该酶的"细筛"编校功能受到损害。

Objective Consequently, by constructing the pcDNA3-HA-hdacl, a HDAC1 eukaryotic expression vector, we were to study the interaction between HDAC1 and ERa and ERB in vitro and the effects of HDAC1 on the ERa and ERB at the protein level. So we can partly reveal the multiplication, differentiation and cancerization of lacteal gland cells.

目的 本文意在通过构建可在真核细胞中表达的重组质粒pcDNA3-HA-hdacl，研究组蛋白去乙酰化酶1(HDAC1)和雌激素受体ERα和ERβ在体外的相互结合作用，以及HDAC1对ERα和ERβ蛋白水平的影响规律，从而在一定角度揭示乳腺细胞的增殖、分化和癌变的过程，为更好地寻找治疗癌症的药物靶标打下基础。

Result succinylation modified, trypsin hydrolysis, SDS and β-mercaptoethanol treatment greatly reduced lectin from gill of bighead carp; dimethyl sulfoxide, NaCl, tri fluoroacetic acid at a given treated concentration had no effect on its activity; lectin from gill of bighead carp agglutinated Haenatcoccus pluvialis, vibrio harveyi and Vibrioauguil larum specifically.

结果］琥珀酰化修饰、胰蛋白酶水解、SDS及β-巯基乙醇处理均使鳙鳃凝集素活性大大降低；在设定的处理浓度下，二甲基亚砜、NaCl及三氟乙酸对其活性没有影响；鳙鳃凝集素能专一地凝集雨生红球藻及哈维氏弧菌和鳗弧菌。

The molecular charge distribution of the reactivator is affect the reactivating efficacy directly. Moreover its association with hydroximic acid dissociation constant pAa closely, and it will have a great impact on reactivating ability indirectly.(3) There is likely to exist front molecular interaction between Cholinesterase Reactivators and OPC-inhibited AChE, the action sites mainly lie on the aromatic ring, the substitute R and the hydroixic acid group. They act on the aromatic residues of AChE by Π-Π conjugation .(4) The reached results by Comparative Molecular Field Analysis is useful to design new higher efficacy derivatives for 1, 2, 4-oxadiazole class nonquaternary Cholinesterase Reactivators.

2复能剂分子的电荷分布直接影响复活活性，同时对肟酸解离常数pKa具有重要影响，间接影响复活能力；(3)复能剂与磷酰化酶可能存在前线轨道作用，作用部位可能主要在芳香环及其取代基R和肟基上，与AchE的芳香族残基发生л-л电子作用；(4)通过比较分子力场法研究可以指导1，2，4-oxadiazole类非季铵肟胆碱酯酶重活化剂新化合物的合成，可能得到活性更高的复能剂。

Halogen acetylized crosslinked polystyrene resin is used for replacing commonly used methyl chloride polystyrene resin.

用卤乙酰化聚苯乙烯树脂代替了通常所用的氯甲基聚苯乙烯树脂。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。