酰化

However, because acetylation and methylation are driven by cell signals, the epigenome is dynamic, enabling it to respond to the environment.

但是，因为乙酰化和甲基化是通过细胞信号驱动的，表观组是动态的，使得它能够对环境进行反应。

It is existed competitiveness inhibition of 6APA, non-competitiveness inhibition of PAA and substrate inhibition of Penicillin on the hydrolysis of benzylpenicillin to 6APA and PAA by an immobilized penicillin amidase. The heat conductive coefficients were determined on the vacuum elevation liquid membrane concentration. The thermodynamics and kinetics of PAA extraction were studied on the organic solvent extraction of the above solution.

研究证明固定化青霉素酰化酶裂解反应是典型的底物、产物抑制酶反应，其反应动力学数据表明，青霉素、苯乙酸以及6APA对反应分别存在底物抑制、非竞争性抑制和竞争性抑制；真空升膜浓缩适应热敏性以及粘度不大的物系，对于6APA水溶液的真空升膜浓缩过程研究得到了浓缩实验的传热系数；浓缩液萃取主要是提取出其中的苯乙酸，本文测定了不同温度以及溶剂条件下的苯乙酸溶解度，并观测了苯乙酸萃取动力学。

There is abnormally high uptake of 11-C-choline in a lung tumor, and the activities of both ChAT and ChoK are increased in cells of lung cancer.

肺癌的胆碱显像有异常增高，其增高原因与肺癌细胞中胆碱代谢的磷酸化途径及乙酰化途径增高有关。

All compounds are synthesized starting from the acylation reaction of gallic acid with L-glutamine to form the basic scaffold, followed by the cyclic reaction in acetic anhydride and the key intermediate cyclic anhydride (compound 4) was obtained. The intermediate compound is condensed with different amino acids or primary amines, and produces the target compounds.

本研究以L－谷氨酸为基本骨架，与甲醚化保护的没食子酸缩合后，经过酰化、环合反应得到关键中间体环状酸酐（化合物4），再经胺解反应合成目标化合物，其化学结构经过红外光谱、电喷雾质谱和核磁共振谱（氢谱、碳谱、碳氢异核多键相关谱）确证。

Here we overview the current research finding on histone methylation, deacetylation and both in cardiovascular disease.

本文就最近有关组蛋白甲基化和去乙酰化及其在心血管疾病中的研究进展做一综述。

Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials.

靶向DNA甲基化和组蛋白去乙酰化酶的几个表观药物已经在临床试验中被测试。

In this issue, now show that the multisubunit histone acetyltransferase Elongator may regulate migration and branch formation of cortical neurons in the developing mouse brain by acetylating -tubulin.

本文研究显示，在老鼠大脑发育时期，多亚基组蛋白乙酰基转移酶Elongator能通过乙酰化微管蛋白，调控大脑皮层神经分支的迁移与形成。

The optimal operation condition of Friedel-Crafts acylation for product Ⅰ was determined by orthogonal experiment: 0.02mol N-ethyl- carbazol, n Benzoyl chloride/n N-ethyl- carbazol=1.2, n AlCl3/n N-ethyl- carbazol=1.2 , at 25 oC for 3.5h. The yield was 94.6%.

通过正交设计实验，探讨了产物Ⅰ的Friedel-Crafts 酰化的最佳反应条件：N-乙基咔唑为0.02mol时，反应物苯甲酰氯与N-乙基咔唑摩尔配比为1.2。，催化剂AlCl3与N-乙基咔唑摩尔配比为1.2， 25℃下反应3.5h，产率可达94.6%。

The invention adopts halogen acetylized crosslinked polystyrene resin and hydroxybenzyl alcohol as the raw material, and the solid phase synthesis carrier with hydroxymethyl as the active group is synthesized through the joint catalysis of N, N-dimethyl formamide used as the reaction solvent, inorganic base and phase-transfer catalyst.

本发明采用卤乙酰化交联聚苯乙烯树脂和对羟基苯甲醇为原料，在以N，N-二甲基甲酰胺为反应溶剂、无机碱及相转移催化剂的共同催化下合成了一种以羟甲基为活性基团的固相合成载体。

In the third step, when the ratio of racemic ester to benzenesulfonyl chloride to triethylamine to catalyst 4-DMAP is 1:1:1:0.1 in 10℃, the yield is 82.9% and high purity is obtained by crystallisation.

在第三步磺酰化反应中，得到合成消旋2-苯磺酸基-2(2-氯苯基)乙酸甲酯的较佳反应条件为邻氯扁桃酸甲酯：苯磺酰氯：三乙胺=1：1：1，催化剂4-DMAP用量为摩尔反应物的10%，反应温度为10℃，收率为82.9%，同时用结晶方法获得高纯度的产物。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。