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Objective:The present study investigated the inhibitory effects of Chinese herb component sinapine on activity of acetylcholinesterasein cerebral homogenate and blood serum of rats.

中文摘要:目的:考察中药单体芥子碱(3,5-二甲基,4-羟基苯丙烯酰胆碱,sinapine)对大鼠血清和大鼠大脑匀浆乙酰胆碱酯酶(acetylcholinesterase,AChE)的体外抑制作用。

Sinapine could significantly inhibit the cerebral AChE activity and may be a promising drug used for prevention and cure of Alzheimer's disease as a cholinesterase inhibitor.

芥子碱能显著抑制脑组织AChE活性,有可能作为中枢乙酰胆碱酯酶抑制剂(acholinesterase inhibi-tors,AChEIs)具有防治阿尔茨海默病(Alzheimer's disease,AD)的应用前景。

I also use a medicine called Trental or Pentoxifylline as a phosphodiesterase inhibitor.

我也使用磷酸二酯酶抑制剂如巡能泰或己酮可可碱进行治疗。

The patients with IMS,when they have difficulty in breathing,should be put under treatmentwith respirator and treated with pralidoxime in addition to aˉtropine.

IMS患者出现呼吸衰竭时应使用呼吸机治疗,同时合理使用阿托品、胆碱酯酶复能剂。

The results showed that (1) the positive staining of ChAT was obviously observed in the cells of the three kinds of human pituitary adenoma, however, it was lower than that in normal human pituitary gland;(2) ACh had a similar effect on the proliferation of the three kinds of human pituitary adenoma cells. ACh at 0.1~10 μmol/L decreased the [3H]TdR incorporation and the MTT A value in a dose-dependent manner. At the same time, ACh decreased the ratio of S or G2 phase pituitary adenoma cells significantly, but increased the ratio of G1 phase pituitary tumour cells markedly;(3) the effect of acetylcholine on the proliferation of human pituitary adenoma cells was inhibited by atropine, but not by tubocurarine;(4) ACh had no effect on the apoptosis of human pituitary adenoma cells cultured in vitro.

结果发现:(1)三种垂体腺瘤细胞中均有胆碱酯酶的表达,但明显少于正常垂体;(2)ACh对三种类型的人垂体腺瘤细胞增殖代谢的影响相类似,不同浓度的ACh能明显抑制体外培养的三种人垂体腺瘤细胞的增殖,呈明显的剂量效应关系,同时ACh能减少垂体腺瘤细胞进入S、G2期的细胞比例,而使处于G1期的细胞比例增加;(3)ACh的这种作用可被阿托品阻断,但不受筒箭毒的影响;(4)ACh对体外培养的三种人垂体腺瘤细胞凋亡无明显影响。

Methods Serum transferrin of 100 patients with different types of hepatitis were determined with immuno turbidimetry and compared with prothrombin time, serum bilirubin and serum cholinesterase.

采用免疫比浊法检测100例不同临床类型病毒性肝炎病人的TF,同时检测凝血酶原时间、血清总胆红素、血清胆碱酯酶

Objective: To investigate the protective effect of cholinergic anti-inflammatory pathway via vagotomy, vagus nerve stimulation and acetylcholinesterase inhibitors during lung ischemia-reperfusion injury.

目的:通过刺激和切断迷走神经或运用抗胆碱酯酶药物研究胆碱能抗炎通路对肺缺血再灌注损伤的影响。

Objective: To research the expression of phosphodiesterase 3A (PDE3A) in zygote of mouse during the first mitosis.

目的:研究磷酸二酯酶3A(PDE3A)在小鼠受精卵第1次有丝分裂中的表达。

Ii increased leels of cholinesterase of lymphocyte origin could interfere with the secretory actiity of submandibular acinar cells, and

测定原淋巴细胞的乙酰胆碱酯酶增长水平是否能影响颌下腺泡细胞的分泌活性

Results:Fractions extracted from Acorus tatarinowii Schott could enhance intelligence in multi-tests, inhibit AchE activity, and promote of c-jun gene.

结果 :石菖蒲提取物在多种实验中有改善学习记忆障碍的作用,并能降低乙酰胆碱酯酶活力,增强c -jun基因表达。

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According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。